Results 11 to 20 of about 5,587 (151)

An optimized luciferin formulation for NanoLuc-based in vivo bioluminescence imaging [PDF]

Scientific Reports
Bioluminescence imaging (BLI) is widely used in preclinical biomedical research for noninvasive tracking of cell populations and biochemical events in vivo.
Chao Gao, Yan Wu, Connor Fitzgerald, Hui Wang, Tim Ugo, Tetsuo Uyeda, Wenhui Zhou, Yichi Su, Thomas A. Kirkland, Michael Z. Lin   +9 more
doaj   +2 more sources

A brittle star is born: Ontogeny of luminous capabilities in Amphiura filiformis. [PDF]

PLoS ONE
Bioluminescence is the production of visible light by living organisms thanks to a chemical reaction, implying the oxidation of a substrate called luciferin catalyzed by an enzyme, the luciferase.
Constance Coubris, Laurent Duchatelet, Sam Dupont, Jérôme Mallefet   +3 more
doaj   +2 more sources

Investigation of the Superoxide Anion-Triggered Chemiluminescence of Coelenterazine Analogs

Applied Sciences, 2023
Reactive oxygen species (ROS), including superoxide anion, are involved in regulating various signaling pathways and are also responsible for oxidative stress. Sensing superoxide anion is of particular importance due to its biological significance.
El Hadi Erbiai, Patricia González-Berdullas, Joaquim C. G. Esteves da Silva, Luís Pinto da Silva   +3 more
doaj   +1 more source

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin.

PLoS ONE, 2021
The Ca2+-binding photoprotein aequorin is a complex of apoAequorin (apoprotein) and (S)-2-peroxycoelenterazine. Aequorin can be regenerated by the incubation of apoAequorin with coelenterazine and molecular oxygen (O2).
Satoshi Inouye, Yuto Sumida, Yuri Tomabechi, Jumpei Taguchi, Mikako Shirouzu, Takamitsu Hosoya   +5 more
doaj   +1 more source

Coelenterazine Indicators for the Specific Imaging of Human and Bovine Serum Albumins

Sensors, 2023
Albumin assays in serum are important for the prognostic assessment of many life-threatening diseases, such as heart failure, liver disease, malnutrition, inflammatory bowel disease, infections, and kidney disease. In this study, synthetic coelenterazine
Sung-Bae Kim, Genta Kamiya, Tadaomi Furuta, Nobuo Kitada, Shojiro A. Maki   +4 more
doaj   +1 more source

Evidence for de novo Biosynthesis of the Luminous Substrate Coelenterazine in Ctenophores

iScience, 2020
Summary: Coelenterazine is a key substrate involved in marine bioluminescence which is used for light-production by at least nine phyla. Some luminous animals, such as the hydromedusa Aequorea, lack the ability to produce coelenterazine endogenously and ...
Manabu Bessho-Uehara, Wentao Huang, Wyatt L. Patry, William E. Browne, Jing-Ke Weng, Steven H.D. Haddock   +5 more
doaj   +1 more source

Development of a Coelenterazine Derivative with Enhanced Superoxide Anion-Triggered Chemiluminescence in Aqueous Solution

Chemosensors, 2022
Superoxide anion is a reactive oxygen species (ROS) of biological interest. More specifically, it plays a role in intra- and intercellular signaling, besides being associated with conditions such as inflammation and cancer.
José Pedro Silva, Patricia González-Berdullas, Joaquim C. G. Esteves da Silva, Luís Pinto da Silva   +3 more
doaj   +1 more source

C-Series Coelenterazine-Driven Bioluminescence Signature Imaging

International Journal of Molecular Sciences, 2022
The present study introduces a unique BL signature imaging system with novel CTZ analogues named “C-series.” Nine kinds of C-series CTZ analogues were first synthesized, and BL intensity patterns and spectra were then examined according to the marine luciferases.
Genta Kamiya, Nobuo Kitada, Tadaomi Furuta, Takashi Hirano, Shojiro Maki, Sung Bae Kim   +5 more
openaire   +2 more sources

Core‐Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties [PDF]

Chemistry – A European Journal, 2020
AbstractIn this work on the design and studies of luciferins related to the blue‐hued coelenterazine, the synthesis of heterocyclic analogues susceptible to produce a photon, possibly at a different wavelength, is undertaken. Here, the synthesis of O‐acetylated derivatives of imidazo[1,2‐b]pyridazin‐3(5 H)‐one, imidazo[2,1‐f][1,2,4]triazin‐7(1 H)‐one ...
Glwadys Gagnot, Vincent Hervin, Eloi P. Coutant, Sophie Goyard, Yves Jacob, Thierry Rose, Fatima Ezzahra Hibti, Alessia Quatela, Yves L. Janin   +8 more
openaire   +3 more sources

Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis. [PDF]

PLoS ONE, 2015
The biosynthesis of the luciferin coelenterazine has remained a mystery for decades. While not all organisms that use coelenterazine appear to make it themselves, it is thought that ctenophores are a likely producer.
Warren R Francis, Nathan C Shaner, Lynne M Christianson, Meghan L Powers, Steven H D Haddock   +4 more
doaj   +1 more source