Results 51 to 60 of about 5,587 (151)

Techniques to Detect and Quantify the Bacterial Metalloprotease AprX in Bovine Milk: A Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT The heat‐stable metalloprotease AprX, secreted by psychrotrophic Pseudomonas spp., is a major cause of quality deterioration in dairy products, particularly ultrahigh temperature (UHT) milk. This review synthesizes the evolution and current state of detection and quantification techniques for AprX in bovine milk, covering traditional ...
Aritra Sinha, Alan L. Kelly
wiley   +1 more source

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Color-tunable bioluminescence imaging portfolio for cell imaging

Scientific Reports, 2021
The present study describes a color-tunable imaging portfolio together with twelve novel coelenterazine (CTZ) analogues. The three groups of CTZ analogues create diverse hues of bioluminescence (BL) ranging from blue to far red with marine luciferases ...
Shota Tamaki, Nobuo Kitada, Masahiro Kiyama, Rika Fujii, Takashi Hirano, Sung Bae Kim, Shojiro Maki   +6 more
doaj   +1 more source

GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats

Journal of Neuroendocrinology, Volume 38, Issue 2, February 2026.
GHSR agonism increases blood glucose, inhibits locomotor activity and delays food intake in GHSR hyperresponsive rats. Abstract Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival.
Philippe Zizzari, Olalla Ramírez‐Penas, Véronique Pons, Matilda Oujezdska, Ange‐Louis Sammarcelli, Thomas Saint‐Yves, Inès Chevallier‐Chantepie, Lucile Baussart, Vanessa Nhan, Adèle Phalip, Céline Gales, Daniela Cota, Florence Noble, Jacques Pantel   +13 more
wiley   +1 more source

Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae

Bio-Protocol, 2017
The proof of concept for bioluminescence monitoring of neural activity in zebrafish with the genetically encoded calcium indicator GFP-aequorin has been previously described (Naumann et al., 2010) but challenges remain.
Steven Knafo, Andrew Prendergast, Olivier Thouvenin, Sophie Figueiredo, Claire Wyart   +4 more
doaj   +1 more source

New bioluminescent coelenterazine derivatives with various C-6 substitutions

Organic & Biomolecular Chemistry, 2017
A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates.
Tianyu Jiang, Xingye Yang, Yubin Zhou, Ilia Yampolsky, Lupei Du, Minyong Li   +5 more
openaire   +3 more sources

Therapeutic Potential of Sodium Selenite Application for Promoting Radioactive Iodine Avidity in Papillary Thyroid Cancer

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
Objective Radioactive iodine therapy is a mainstay for recurrent and metastatic differentiated thyroid cancer. However, a substantial portion of differentiated thyroid cancer patients exhibits dedifferentiation status with a lack of sodium iodide symporter functionality and expression, as well as downregulated thyroid‐specific proteins and ...
Ji Min Oh, Ramya Lakshmi Rajendran, Prakash Gangadaran, Chae Moon Hong, Byeong-Cheol Ahn, Guillermo Mendoza-Diaz   +5 more
wiley   +1 more source

Bioluminescent Mammalian Cells Grown in Sponge Matrices to Monitor Immune Rejection

Molecular Imaging, 2007
The growth and bioluminescence of cells seeded in collagen and gelatin sponge matrices were compared in vitro under different conditions, and immune rejection was quantified and visualized directly in situ based on loss of bioluminescence activity ...
Okechukwu Ojogho, Alice Li, Craig W. Zuppan, Alan Escher   +3 more
doaj   +1 more source