Results 61 to 70 of about 5,587 (151)
Journal of Immunology Research, Volume 2026, Issue 1, 2026.The effective trafficking of dendritic cells (DCs) to the lymph nodes (LNs), orchestrated by CC‐chemokine receptor 7 (CCR7) and its ligand CCL21, is essential for the success of DC–based immunotherapies. This study explores the potential of C21TP, a naturally occurring basic peptide derived from the C‐terminal of CCL21, to enhance DC homing to the ...
Marina Barrio-Calvo +8 more
wiley +1 more source
Membrane permeability of coelenterazine analogues measured with fish eggs [PDF]
Biochemical Journal, 1997 To determine the suitability of various coelenterazine analogues for the regeneration of aequorin in living cells, the membrane permeabilities of 11 analogues were measured using the eggs of the killifish Fundulus grandis by soaking the eggs in solutions containing the analogues.
openaire +2 more sources
ChemMedChem, Volume 20, Issue 24, December 15, 2025.The [F7,P34]‐pNPY based peptide‐drug conjugate targets the Y1 receptor and induces internalization. Once inside the cell, 4‐hydroxytamoxifen is cleaved from the peptide and is released into the cytosol, where it activates the estrogen receptor α. This dual‐targeting mechanism aims to promote body weight loss and offers a potential therapeutic strategy ...
Anna Kohler +4 more
wiley +1 more source
Development of a Genetically Encoded and Potent PDE6D Inhibitor
ChemBioChem, Volume 26, Issue 24, December 11, 2025.PDE6D is a trafficking chaperone of prenylated proteins. Current small molecule PDE6D inhibitors target its hydrophobic pocket, rendering them typically poorly water soluble. Herein, PDE6D binders are generated by combining parts of the K‐Ras4B and INPP5E C‐termini. The genetically encoded high‐affinity PDE6D inhibitor SNAP‐STI is thus generated.
Atanasio Gómez‐Mulas +7 more
wiley +1 more source
Molecular Imaging, 2011 Bioluminescence imaging (BLI) of luciferase reporters provides a cost-effective and sensitive means to image biological processes. However, transport of luciferase substrates across the cell membrane does affect BLI readout intensity from intact living ...
Ruimin Huang +3 more
doaj +1 more source
Regiospecific Coelenterazine Analogs for Bioassays and Molecular Imaging
Bioconjugate ChemistryBioluminescence (BL) generated by luciferase-coelenterazine (CTZ) reactions is broadly employed as an optical readout in bioassays and in vivo molecular imaging. In this study, we demonstrate a systematic approach to elucidate the luciferase-CTZ binding chemistry with a full set of regioisomeric CTZ analogs, where all the functional groups were ...
Genta Kamiya +7 more
+5 more sources
Genetically Modified Coelenterazine-Dependent Luciferases as Reporters for In Vitro Assay [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2017 Among the most important tasks of modern biotechnology is the development of new analytical techniques suitable for highly sensitive and specific detection of diagnostically important targets rapidly expanding their range with the progress in biomedical ...
Ludmila A. Frank +3 more
doaj
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level
Nature CommunicationsEpilepsy affects 1% of the general population and 30% of patients are resistant to antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of illuminating deep brain areas poses translational challenges.
Assunta Merolla +13 more
doaj +1 more source
International Journal of Nanomedicine, 2012 Qiang Wu, Maoquan ChuSchool of Life Science and Technology, Tongji University, Shanghai, People's Republic of ChinaAbstract: Quantum dots (QDs) show promise as novel nanomaterials for sentinel lymph node (SLN) mapping through their use in ...
Wu Q, Chu M
doaj
Molecular Imaging, 2004 In vivo imaging of bioluminescent reporters relies on expression of light-emitting enzymes, luciferases, and delivery of chemical substrates to expressing cells.
Hui Zhao +6 more
doaj +1 more source