Results 1 to 10 of about 25,277,741 (360)
Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Yevgeniya I. Shurubor +7 more
semanticscholar +3 more sources
Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration
EMBO Molecular Medicine, 2016 Pantothenate kinase‐associated neurodegeneration (PKAN) is an early onset and severely disabling neurodegenerative disease for which no therapy is available.
Daniel I. Orellana +15 more
semanticscholar +2 more sources
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
Nature, 2022 In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing cofactor production and ...
Christian C. Dibble +15 more
semanticscholar +1 more source
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2022 Multiple mitochondrial matrix enzymes playing key roles in metabolism require cofactors for their action. Due to the high impermeability of the mitochondrial inner membrane, these cofactors need to be synthesized within the mitochondria or be imported ...
F. Palmieri +3 more
semanticscholar +1 more source
eLife, 2021 TMEM120A, also named as TACAN, is a novel membrane protein highly conserved in vertebrates and was recently proposed to be a mechanosensitive channel involved in sensing mechanical pain.
Jing Xue +8 more
doaj +1 more source
Pantothenic acid – a scoping review for Nordic Nutrition Recommendations 2023
Food & Nutrition Research, 2023 Pantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP).
Riitta Freese +2 more
doaj +1 more source
A conserved oxalyl-coenzyme A decarboxylase in oxalate catabolism
Plant Signaling & Behavior, 2022 The ability to biosynthesize oxalic acid can provide beneficial functions to plants; however, uncontrolled or prolonged exposure to this strong organic acid results in multiple physiological problems.
Ninghui Cheng +4 more
doaj +1 more source
Effects of ligand binding on the energy landscape of acyl-CoA-binding protein [PDF]
Biophys. J. 119 (2020) 1821-1832, 2021 Binding of ligands is often crucial for function yet the effects of ligand binding on the mechanical stability and energy landscape of proteins are incompletely understood. Here we use a combination of single-molecule optical tweezers and MD simulations to investigate the effect of ligand binding on the energy landscape of acyl-coenzyme A (CoA) binding
arxiv +1 more source
Medicina Interna, 2020 coenzyme containing pantothenic acid, adenosine 3-phosphate 5-pyrophosphate, and cysteamine; involved in the transfer of acyl groups, notably in transacetylations.
S. Comorosan, I. Mincu
semanticscholar +2 more sources
Frontiers in Microbiology, 2021 Mycoplasmas are responsible for a wide range of disease states in both humans and animals, in which their parasitic lifestyle has allowed them to reduce their genome sizes and curtail their biosynthetic capabilities.
Tertius Alwyn Ras +2 more
doaj +1 more source