Results 11 to 20 of about 254,469 (341)

Remnants of an ancient metabolism without phosphate [PDF]

, 2017
Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E., Hartman, Hyman, Segrè, Daniel, Smith, Temple F.   +3 more
core   +1 more source

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) [PDF]

, 2014
Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt
Alan Scott, Andrew D. Lawrence, Banerjee, Blanche, Cheng, Cheung, Christopher M. Johnson, Dalhus, Daragan, Debussche, Delaglio, Delaglio, Emsley, Evans, Fogh, Fonseca, Johnson, Kim, Lawrence, Leslie, Lexa, Mark J. Howard, Martin J. Warren, Mera, Michael A. Geeves, Michelle L. Rowe, Monera, Murshudov, Pace, Parsons, Piotto, Rashid, Richard W. Pickersgill, Samantha L. Taylor, Sampson, States, Stephen E. J. Rigby, Stich, Stich, Vagin, van den Heuvel, Vranken, Warren, Webb, Wishart, Wittung-Stafshede   +45 more
core   +3 more sources

Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection

Molecules, 2017
Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Yevgeniya I. Shurubor, Marilena D’Aurelio, Joanne Clark-Matott, Elena P. Isakova, Yulia I. Deryabina, M. Flint Beal, Arthur J. L. Cooper, Boris F. Krasnikov   +7 more
doaj   +1 more source

Auxotrophic Selection Strategy for Improved Production of Coenzyme B12 in Escherichia coli

iScience, 2020
Summary: The production of coenzyme B12 using well-characterized microorganisms, such as Escherichia coli, has recently attracted considerable attention to meet growing demands of coenzyme B12 in various applications. In the present study, we designed an
Myung Hyun Noh, Hyun Gyu Lim, Daeyeong Moon, Sunghoon Park, Gyoo Yeol Jung   +4 more
doaj   +1 more source

Investigation of coenzyme Q10 status, serum amyloid-β, and tau protein in patients with dementia

Frontiers in Aging Neuroscience, 2022
ObjectivesDementia is an oxidative stress-related disease. Coenzyme Q10 is a nutrient that occurs naturally in the human body and acts as an antioxidant.
Po-Sheng Chang, Po-Sheng Chang, Hsi-Hsien Chou, Hsi-Hsien Chou, Te-Jen Lai, Te-Jen Lai, Chi-Hua Yen, Chi-Hua Yen, Ji-Cyun Pan, Ping-Ting Lin, Ping-Ting Lin   +10 more
doaj   +1 more source

Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10

Drug Delivery, 2022
Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral bioavailability.
Thapa Chhitij, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Santosh Bashyal, Shrawani Lamichhane, Jung Hwan Kim, Jae Heon Lee, Jee Hun Park, Jaewoong Choi, Se Hyun Song, Sangkil Lee   +11 more
doaj   +1 more source

Clinical syndromes associated with Coenzyme Q10 deficiency. [PDF]

, 2018
Primary Coenzyme Q deficiencies represent a group of rare conditions caused by mutations in one of the genes required in its biosynthetic pathway at the enzymatic or regulatory level.
Alc\ue1zar-Fabra, Maria, Brea-Calvo, Gloria, Trevisson, Eva   +2 more
core   +1 more source

Urinary coenzyme Q10 as a diagnostic biomarker and predictor of remission in a patient with ADCK4-associated Glomerulopathy: a case report

BMC Nephrology, 2021
Background AarF domain-containing kinase 4 (ADCK4)-associated glomerulopathy is a mitochondrial nephropathy caused by mutations in the ADCK4 gene, which disrupt coenzyme Q10 biosynthesis.
Yan Zhang, Xiaohua Liao, Yupeng Jiang, Xin Lv, Yue Yu, Qin Dai, Liyun Ao, Lijian Tao, Zhangzhe Peng   +8 more
doaj   +1 more source

The Structural Basis of Coenzyme A Recycling in a Bacterial Organelle. [PDF]

, 2016
Bacterial Microcompartments (BMCs) are proteinaceous organelles that encapsulate critical segments of autotrophic and heterotrophic metabolic pathways; they are functionally diverse and are found across 23 different phyla. The majority of catabolic BMCs (
Erbilgin, Onur, Kerfeld, Cheryl A, Sutter, Markus   +2 more
core   +3 more sources

Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration

Brain Sciences, 2021
Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
Luca Mignani, Barbara Gnutti, Daniela Zizioli, Dario Finazzi   +3 more
doaj   +1 more source