The Structural Basis of Coenzyme A Recycling in a Bacterial Organelle [PDF]
PLoS Biology, 2016 Bacterial Microcompartments (BMCs) are proteinaceous organelles that encapsulate critical segments of autotrophic and heterotrophic metabolic pathways; they are functionally diverse and are found across 23 different phyla. The majority of catabolic BMCs (
Onur Erbilgin, M. Sutter, C. Kerfeld
semanticscholar +5 more sources
ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway [PDF]
Scientific ReportsThe most common mutation in southern Chinese individuals with late-onset multiple acyl-coenzyme A dehydrogenase deficiency (MADD; a fatty acid metabolism disorder) is c.250G > A (p.Ala84Thr) in the electron transfer flavoprotein dehydrogenase gene (ETFDH)
Chuang-Yu Lin +5 more
doaj +2 more sources
Prebiotic Vitamin B$_3$ Synthesis in Carbonaceous Planetesimals [PDF]
ChemPlusChem 2023, e202300508, 2023 Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life.
arxiv +1 more source
Fluorescent redox-dependent labeling of lipid droplets in cultured cells by reduced phenazine methosulfate [PDF]
Heliyon, volume 6, pages e04182, 2020, 2021 Natural and synthetic phenazines are widely used in biomedical sciences. In dehydrogenase histochemistry, phenazine methosulfate (PMS) is applied as a redox reagent for coupling reduced coenzymes to the reduction of tetrazolium salts into colored formazans.
arxiv +1 more source
Annals of Neurology, 2020 Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease‐modifying treatments are approved.
S. Nuber +15 more
semanticscholar +1 more source
Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Nature Cell Biology, 2023 Deshwal et al. show that the protease PARL regulates coenzyme Q (CoQ) via the lipid transfer protein STARD7. Mitochondrial STARD7 ensures CoQ synthesis; cytosolic STARD7 preserves CoQ transport to the membrane, protecting cells against ferroptosis ...
Soni Deshwal +9 more
semanticscholar +1 more source
The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment
Physiological Reports, 2021 Leg cramping is a common side effect of hemodialysis, and this is frequently treated by the administration of carnitine, but this is not effective in every patient. Alkalosis is a key component of the etiology of leg cramping during hemodialysis sessions.
Akira Takahashi
doaj +1 more source
FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) [PDF]
, 2014 Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt
Alan Scott +45 more
core +3 more sources
Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]
, 2015 Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk +9 more
core +1 more source
The effects of coenzyme Q10 (CoQ10) on Ionizing radiation- induced pancreatic β-cell injury [PDF]
, 2023 Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation induced oxidative damage in pancreatic & beta;-cells. Methods: Twenty-four male rats were assigned to 4 groups. Group 1 constituted the control group, Group 2
Mercantepe, Filiz +3 more
core +1 more source