Frontiers in Cellular and Infection Microbiology, 2021 Coenzyme A (CoA) is a well-known cofactor that plays an essential role in many metabolic reactions in all organisms. In Plasmodium falciparum, the most deadly among Plasmodium species that cause malaria, CoA and its biosynthetic pathway have been proven ...
Arif Nurkanto +15 more
doaj +1 more source
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline [PDF]
, 2010 Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests.
Allan J. Tobin +13 more
core +3 more sources
Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration
Brain Sciences, 2021 Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
Luca Mignani +3 more
doaj +1 more source
Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme. [PDF]
, 2019 Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Mok, Kenny +5 more
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ACS Infectious Diseases, 2017 Previously, we showed that a major in vitro and in vivo mechanism of resistance to pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug pyrazinamide (PZA), involves missense mutations in the aspartate decarboxylase ...
Pooja Gopal +10 more
semanticscholar +1 more source
Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue [PDF]
, 2005 ObjectivesPrevious clinical trials suggest that coenzyme Q10 might afford myocardial protection during cardiac surgery. We sought to measure the effect of coenzyme Q10 therapy on coenzyme Q10 levels in serum, atrial trabeculae, and mitochondria; to ...
Bailey, Michael +12 more
core +1 more source
Functions of Coenzyme A and Acyl-CoA in Post-Translational Modification and Human Disease
Frontiers in Bioscience-LandmarkCoenzyme A (CoA) is synthesized from pantothenate, L-cysteine and adenosine triphosphate (ATP), and plays a vital role in diverse physiological processes. Protein acylation is a common post-translational modification (PTM) that modifies protein structure,
Jumin Xie +4 more
doaj +1 more source
Biology, 2017 The coenzyme A (CoA)-independent transacylation system catalyzes fatty acid transfer from phospholipids to lysophospholipids in the absence of cofactors such as CoA.
A. Yamashita +8 more
semanticscholar +1 more source
Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up [PDF]
, 2015 The aim was to evaluate circulating levels of reactive oxygen species (ROS) and changes in central macular thickness (CMT) in patients with nonproliferative diabetic retinopathy (NPDR) after antioxidant supplementation.
Carnevale, Carmela +5 more
core +4 more sources
The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
Frontiers in Bioscience-LandmarkCoenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie +4 more
doaj +1 more source