Ubiquinone (Coenzyme Q-10) Supplementation Influences Exercise-Induced Changes in Serum 25(OH)D3 and the Methyl-Arginine Metabolites: A Double-Blind Randomized Controlled Trial. [PDF]
Mieszkowski J +9 more
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Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease. [PDF]
Hernández-Camacho JD +9 more
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Coenzyme Q<sub>10</sub> as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs. [PDF]
Anderson RF, Qi W.
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Clinical Features, Biochemistry, Imaging, and Treatment Response in a Single-Center Cohort With Coenzyme Q10 Biosynthesis Disorders. [PDF]
Wahedi A +10 more
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The Scavenging Activity of Coenzyme Q10 Plus a Nutritional Complex on Human Retinal Pigment Epithelial Cells. [PDF]
Hernandez M +8 more
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AbstractThe key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated.
D James, Morré, Dorothy M, Morré
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Coenzyme Q and Phenylketonuria
Nature, 1964INVESTIGATIONS by Olson's group1,2 of the biosynthesis of coenzyme Q9 (ubiquinone-45) in the rat have shown that phenylalanine is a metabolic precursor of the benzoquinoid ring of coenzyme Q. Presumably, hydroxylation of phenylalanine to yield tyrosine would be an intermediate step in the biosynthesis of coenzyme Q (ref. 3).
E A, NAPIER +3 more
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CONTENTS I. Discovery and natural sources of ubiquinones 414 II. Determination of the structure of ubiquinones 414 III. Synthesis of ubiquinones 415 IV. Conversion products of ubiquinones 418 V. Biosynthesis of ubiquinones 419 VI. Role of ubiquinones in electron transport in oxidative phosphorylation. Hypotheses concerning the possible mechanism of the
G I Samokhvalov, E A Obol'nikova
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Coenzyme Q Cytoprotective Mechanisms
2004Publisher Summary This chapter provides an overview of coenzyme Q (CoQ) cytoprotective mechanisms. CoQ cytoprotective mechanisms can be divided into bioenergetic function and antioxidant activity. To discern to what extent these processes are occurring in cells during cell stress, it is necessary to measure the ability of the CoQ hydroquinone to both
Tom S, Chan +2 more
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Regulation of Coenzyme Q biosynthesis
Molecular Aspects of Medicine, 1994The side-chain moiety of coenzyme Q is synthesized by a trans-prenyltransferase present in microsomes. Condensation of this moiety with the precursor ring takes place in the Golgi system. The enzymes involved, as well as the cytosolic geranylgeranyl-PP synthase, are regulated in an independent fashion. When the size of the farnesyl-PP pool is decreased
E L, Appelkvist +4 more
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