Results 201 to 210 of about 1,766,693 (250)
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Coenzyme Q and Phenylketonuria
Nature, 1964INVESTIGATIONS by Olson's group1,2 of the biosynthesis of coenzyme Q9 (ubiquinone-45) in the rat have shown that phenylalanine is a metabolic precursor of the benzoquinoid ring of coenzyme Q. Presumably, hydroxylation of phenylalanine to yield tyrosine would be an intermediate step in the biosynthesis of coenzyme Q (ref. 3).
E A, NAPIER +3 more
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Coenzyme Q as an Antiadipogenic Factor
Antioxidants & Redox Signaling, 2011Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice.
Bour, Sandy +7 more
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The function of coenzyme Q in mitochondria
The Clinical Investigator, 1993We have accumulated evidence that coenzyme Q (CoQ) concentration in the mitochondrial membrane is not saturating for NADH oxidation but is saturating for succinate and glycerol-3-phosphate oxidation. As a result of its kinetic properties CoQ concentration changes must yield changes in respiration rates.
LENAZ G +8 more
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The Role of Coenzyme Q in Mitochondrial Electron Transport
Mitochondrion, 2007 In mitochondria, most Coenzyme Q is free in the lipid bilayer; the question as to whether tightly-bound, non-exchangeable Coenzyme Q molecules exist in mitochondrial complexes is still an open question.
Maria Luisa Genova +2 more
exaly +2 more sources
BioFactors, 2008
AbstractIn the 50 years since the identification of coenzyme Q as an electron carrier in mitochondria, it has been identified with diverse and unexpected functions in cells. Its discovery came as a result of a search for electron carriers in mitochondria following the identification of flavin and cytochromes by Warburg, Keilin, Chance and others.
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AbstractIn the 50 years since the identification of coenzyme Q as an electron carrier in mitochondria, it has been identified with diverse and unexpected functions in cells. Its discovery came as a result of a search for electron carriers in mitochondria following the identification of flavin and cytochromes by Warburg, Keilin, Chance and others.
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Coenzyme Q. Li. New data on the distribution of coenzyme Q in nature
Archives of Biochemistry and Biophysics, 1964The heart of the rhesus monkey was found to contain coenzyme Q 10 . This experimental primate may serve as a model for studies of CoQ 10 as it may relate to human disease. Frog nerve tissue was also found to contain CoQ 10 . Such tissue may be a useful system for researches on CoQ in nerve physiology.
P H, GALE +3 more
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Estimation of individual coenzyme Q homolgues in a coenzyme Q mixture by densitometry
Journal of Chromatography A, 1972Abstract A method for the densitometric determination of coenzymes Q individual homologues after separation by reversed-phase paper chromaography is described. The parameters associated with the reproducibility and accuracy of the method are discussed.
A C, Casey, P, Myers, A, Lee
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The Diversity of Coenzyme Q Function
Molecular Aspects of Medicine, 1997Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria.
Placido Navas, F L Crane
exaly +3 more sources
The Multiple Functions of Coenzyme Q
Bioorganic Chemistry, 2001The coenzyme function of ubiquinone was subject of extensive studies in mitochondria since more than 40 years. The catalytic activity of ubiquinone (UQ) in electron transfer and proton translocation in cooperation with mitochondrial dehydrogenases and cytochromes contributes essentially to the bioenergetic activity of ATP synthesis.
H, Nohl +3 more
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Coenzyme Q – Biosynthesis and functions
Biochemical and Biophysical Research Communications, 2010In addition to its role as a component of the mitochondrial respiratory chain and our only lipid-soluble antioxidant synthesized endogenously, in recent years coenzyme Q (CoQ) has been found to have an increasing number of other important functions required for normal metabolic processes.
Magnus, Bentinger +2 more
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