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Coenzyme Q – Biosynthesis and functions
Biochemical and Biophysical Research Communications, 2010In addition to its role as a component of the mitochondrial respiratory chain and our only lipid-soluble antioxidant synthesized endogenously, in recent years coenzyme Q (CoQ) has been found to have an increasing number of other important functions required for normal metabolic processes.
Magnus, Bentinger +2 more
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The essential functions of coenzyme Q
The Clinical Investigator, 1993The essential role of coenzyme Q in biological energy transduction is well established. Coenzyme Q is a unique carrier for two-electron transfer within the lipid phase of the mitochondrial membrane. The function is essential for proton-based energy coupling. The sites of entry and exit of electrons into the quinone are at specific quinone-binding sites
F L, Crane, I L, Sun, E E, Sun
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Regulation of Coenzyme Q biosynthesis
Molecular Aspects of Medicine, 1994The side-chain moiety of coenzyme Q is synthesized by a trans-prenyltransferase present in microsomes. Condensation of this moiety with the precursor ring takes place in the Golgi system. The enzymes involved, as well as the cytosolic geranylgeranyl-PP synthase, are regulated in an independent fashion. When the size of the farnesyl-PP pool is decreased
E L, Appelkvist +4 more
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The antioxidant role of coenzyme Q
Mitochondrion, 2007A number of functions for coenzyme Q (CoQ) have been established during the years but its role as an effective antioxidant of the cellular membranes remains of dominating interest. This compound is our only endogenously synthesized lipid soluble antioxidant, present in all membranes and exceeding both in amount and efficiency that of other antioxidants.
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2000
MOLECULAR MECHANISMS OF COENZYME Q Chemical and Biophysical Properties Biochemical Mechanisms in Electron transport in Mitochondria and Extramitochondrial Locations Antioxidant Mechanisms Prooxidant Mechanisms NUTRITIONAL ASPECTS OF COENZYME Q Biosynthesis and Nutritional Sources Dietary Supplementation and Plasma/Tissue Concentrations HEALTH EFFECT OF
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MOLECULAR MECHANISMS OF COENZYME Q Chemical and Biophysical Properties Biochemical Mechanisms in Electron transport in Mitochondria and Extramitochondrial Locations Antioxidant Mechanisms Prooxidant Mechanisms NUTRITIONAL ASPECTS OF COENZYME Q Biosynthesis and Nutritional Sources Dietary Supplementation and Plasma/Tissue Concentrations HEALTH EFFECT OF
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Biosynthesis of coenzyme Q in microorganisms
Archives of Biochemistry and Biophysics, 1965Incorporation of mevalonate-2-C14, acetate-1-C14, and formate-C14 into the lipids of microorganisms was studied. In the case of four bacteria tested—Agrobacterium tumefaciens, Azotobacter vinelandii, Escherichia coli, and a Pseudomonas species—the various homologues of coenzyme Q present were not labeled with any of the tracers used, although ...
Raman, TS +3 more
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Coenzyme Q Cytoprotective Mechanisms
2004Publisher Summary This chapter provides an overview of coenzyme Q (CoQ) cytoprotective mechanisms. CoQ cytoprotective mechanisms can be divided into bioenergetic function and antioxidant activity. To discern to what extent these processes are occurring in cells during cell stress, it is necessary to measure the ability of the CoQ hydroquinone to both
Tom S, Chan +2 more
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Stimulation of coenzyme Q synthesis
BioFactors, 2008AbstractUptake of dietary coenzyme Q (CoQ) into organs is limited but there are some exceptions such as adrenal glands and ovaries. Under deficient conditions an optimal solution could be stimulation of the endogenous synthesis. In rodent exercise, cold exposure and a few substances elevate the CoQ levels to some extent.
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BioFactors, 2011
AbstractThe key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated.
D James, Morré, Dorothy M, Morré
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AbstractThe key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated.
D James, Morré, Dorothy M, Morré
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Coenzyme Q. XXIV. On the significance of coenzyme Q 10 in human tissues
Archives of Biochemistry and Biophysics, 1961Abstract Several organs and tissues of three humans have been examined for coenzyme Q content. The liver, heart, spleen, kidney, pancreas, and adrenals contain relatively high concentrations of coenzyme Q 10, indicating that studies of the functional relationship of coenzyme Q to diseases involving any of these organs might be important.
P H, GALE +4 more
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