Results 171 to 180 of about 105,879 (276)

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, Volume 18, Issue 5, Page 669-677, May 2026.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Coenzyme Q improves mitochondrial and muscle dysfunction caused by CUG expanded repeats in Caenorhabditis elegans. [PDF]

Genetics
Teixeira J, Harju AM, Othman A, Eriksson O, Battersby BJ, Garcia SMDA.   +5 more
europepmc   +1 more source

Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. [PDF]

Nat Cell Biol, 2023
Deshwal S, Onishi M, Tatsuta T, Bartsch T, Cors E, Ried K, Lemke K, Nolte H, Giavalisco P, Langer T.   +9 more
europepmc   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Identification of a new <i>COQ4</i> spliceogenic variant causing severe primary coenzyme Q deficiency. [PDF]

Mol Genet Metab Rep
Alcázar-Fabra M, Østergaard E, Fernández-Ayala DJM, Desbats MA, Morbidoni V, Tomás-Gallado L, García-Corzo L, Blanquer-Roselló MDM, Bartlett AK, Sánchez-Cuesta A, Sena L, Cortés-Rodríguez A, Cascajo-Almenara MV, Pagliarini DJ, Trevisson E, Gronborg SW, Brea-Calvo G.   +16 more
europepmc   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

The Extract of Camellia Seed Cake Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice by Promoting Coenzyme Q Synthesis. [PDF]

Nutrients
Chen X, Chen B, Li Z, Ma L, Zhu Q, Liu C, He H, Zhang Z, Zhou C, Liu G, Zhou Y, Deng S, Guo S, Chen Y.   +13 more
europepmc   +1 more source

COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells

, 2023
Pelosi L, Morbiato L, Burgardt A, Tonello F, Bartlett AK, Guerra RM, Ferizhendi KK, Desbats MA, Rascalou B, Marchi M, Vázquez-Fonseca L, Agosto C, Zanotti G, Roger-Margueritat M, Alcázar-Fabra M, García-Corzo L, Sánchez-Cuesta A, Navas P, Brea-Calvo G, Trevisson E, Wendisch VF, Pagliarini DJ, Salviati L, Pierrel F.   +23 more
europepmc   +1 more source

Proteolytic control of mitochondrial protein translocases

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley   +1 more source

Physiological metabolic analysis and process optimization of hypoxia in promoting coenzyme Q₁₀ biosynthesis and accumulation in <i>Rhodobacter sphaeroides</i> HY01. [PDF]

Synth Syst Biotechnol
Li B, Ge Y, Fu L, Guo H, Mohsin A, Li J, Wu J, Chen B, Zhuang Y, Wang Z.   +9 more
europepmc   +1 more source