Results 91 to 100 of about 37,360 (248)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients [PDF]

, 2016
BACKGROUND: The objective of this study was to evaluate whether the levels of coenzyme Q10 (CoQ10) in brain tissue of multiple system atrophy (MSA) patients differ from those in elderly controls and in patients with other neurodegenerative diseases ...
Bettencourt, C, Chalasani, A, Hargreaves, I, Holton, JL, Houlden, H, Kiely, AP, Neergheen, V, Schottlaender, LV   +7 more
core   +1 more source

Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis

Cell Proliferation, EarlyView.
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley   +1 more source

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

International Journal of Endocrinology, 2018
Objective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine ...
Shi-ying Zhang, Kai-lin Yang, Liu-ting Zeng, Xiao-he Wu, Hui-yong Huang   +4 more
doaj   +1 more source

Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth. [PDF]

, 2015
Low birth weight and rapid postnatal growth increases the risk of developing insulin resistance and type 2 diabetes in later life. However, underlying mechanisms and potential intervention strategies are poorly defined.
Carpenter, Asha, Chen, Jian-Hua, Fernandez-Twinn, Denise S, Hargreaves, Iain P, Madsen, Ralitsa, McConnell, Josie M, Ozanne, Susan E, Tarry-Adkins, Jane L   +7 more
core   +2 more sources

Mutagenicity of Coenzyme Q10

Journal of Nutritional Science and Vitaminology, 2005
Mutagenicity of organically synthesized coenzyme Q10 (CoQ10) was determined by Ames assay in the presence and absence of S9 mix. The tester strains were Salmonella typhimurium TA98, TA100, TA1535, and TA1537, and Escherichia coli WP2 uvr A. CoQ10 displayed no mutagenicity in any tester strain at any dose tested. Therefore, organically synthesized CoQ10
Kazutaka, Ikeda, Yoshio, Suzuki, Ikuo, Yoshimjura   +2 more
openaire   +3 more sources

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Possibilities of coenzyme q10 as a part of complex therapy of patients with chronic heart failure and its influence on indicators of quality of life

Медицинский совет, 2019
The research objective consisted in studying of influence of coenzyme Q10 as a part of complex therapy of patients with the chronic heart failure (CHF) on indicators of quality of life in comparison with traditional therapy without coenzyme Q10 addition.
Zh. M. Sizova, V. L. Zakharova, K. A. Alibeyli   +2 more
doaj   +1 more source

Le fonctionnement du coeur: intérêt des acides gras essentiels et des antioxydants chez les carnivores domestiques [PDF]

, 2010
Depuis de nombreuses années, la prise en charge alimentaire des patients humains atteints d'insuffisance cardiaque a été définie. Outre l'importance d'une alimentation pauvre en sel, un apport élevé en acides gras essentiels et en antioxydants serait un ...
Priymenko, Nathalie, Sagols, Emmanuelle
core  

Medical management of hereditary optic neuropathies. [PDF]

, 2014
Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA).
Barboni, Piero, Carbonelli, Michele, Carelli, Valerio, La Morgia, Chiara, Sadun, Alfredo Arrigo   +4 more
core   +1 more source