Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10
Heart failure (HF) is a global epidemic that contributes to the deterioration of quality of life and its shortening in 1–3% of adult people in the world. Pharmacotherapy of HF should rely on highly effective drugs that improve prognosis and prolong life.
Krzysztof J. Filipiak+3 more
doaj +1 more source
Fluorescent redox-dependent labeling of lipid droplets in cultured cells by reduced phenazine methosulfate [PDF]
Natural and synthetic phenazines are widely used in biomedical sciences. In dehydrogenase histochemistry, phenazine methosulfate (PMS) is applied as a redox reagent for coupling reduced coenzymes to the reduction of tetrazolium salts into colored formazans.
arxiv +1 more source
Effect of Black Sesame Oil Lecithin Solution on Bone Metabolism in Naturally Growing Aged Mice
To observe the effect of black sesame oil lecithin solution on bone metabolism in naturally grown aging mice and compare with vitamin E.8-month-old SPF Kunming mice were randomly divided into normal saline group (NS group),vitamin E group (VE group ...
LV Si-min+5 more
doaj +1 more source
Osteoarthritis (OA) causes oxidative stress. Coenzyme Q10 is an antioxidant that participates in energy production in the human body. The purpose of this study was to investigate the relationships among coenzyme Q10 status, oxidative stress, antioxidant ...
Po-Sheng Chang+4 more
doaj +1 more source
Impact of ciprofloxacin and coenzyme Q10 on spermatogenesis in mice
Background: Ciprofloxacin is commonly used to treat many bacterial infections. There are controversial reports regarding abnormalities in sperm parameters in laboratory animal and human studies after ciprofloxacin administration.
Reshna Kamal Albarzanji+2 more
doaj +1 more source
Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue [PDF]
ObjectivesPrevious clinical trials suggest that coenzyme Q10 might afford myocardial protection during cardiac surgery. We sought to measure the effect of coenzyme Q10 therapy on coenzyme Q10 levels in serum, atrial trabeculae, and mitochondria; to ...
Bailey, Michael+12 more
core +1 more source
Evaluation of The Analgesic Activity of Coenzyme Q10 Ointment in Mice
The aim of this study is to examine analgesic effect of Coenzyme Q10 ointment in mice. Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group.
Ibtisam T. Al-Jureisy+2 more
doaj +1 more source
Study on the technical requirements of coenzyme Q10 as health food raw materials
ObjectiveTo verify the main quality indexes of coenzyme Q10, and study the quality consistency of coenzyme Q10 produced by different processes.MethodsAccording to the Chinese Pharmacopoeia (2020 version) and national food safety standards, the main ...
NING Xiao+6 more
doaj +1 more source
Background: Coenzyme Q10 is formulated into Nanostructured Lipid Carrier (NLC) added with peppermint oil (PO) 0% (F1), 1% (F2), 1.5% (F3) and 2% (F4) to increase its penetration.
Tristiana Erawati+5 more
doaj +1 more source
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline [PDF]
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests.
Allan J. Tobin+13 more
core +3 more sources