Results 21 to 30 of about 80,404 (288)
Effects of ligand binding on the energy landscape of acyl-CoA-binding protein [PDF]
Biophys. J. 119 (2020) 1821-1832, 2021 Binding of ligands is often crucial for function yet the effects of ligand binding on the mechanical stability and energy landscape of proteins are incompletely understood. Here we use a combination of single-molecule optical tweezers and MD simulations to investigate the effect of ligand binding on the energy landscape of acyl-coenzyme A (CoA) binding
arxiv +1 more source
Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics
Antioxidants, 2021 Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the mitochondrial respiratory chain with antioxidant properties widely used as an antiaging health supplement and to relieve the symptoms of many pathological conditions ...
J. M. Suárez-Rivero +8 more
semanticscholar +1 more source
Human Mutation, Volume 43, Issue 12, Page 1970-1978, December 2022., 2022 Abstract Primary mitochondrial diseases are a group of genetically and clinically heterogeneous disorders resulting from oxidative phosphorylation (OXPHOS) defects. COX11 encodes a copper chaperone that participates in the assembly of complex IV and has not been previously linked to human disease. In a previous study, we identified that COX11 knockdown
Rocio Rius +15 more
wiley +1 more source
Effect of iron and silver nanoparticles on coenzyme Q10 production by Gluconobacter japonicus FM10
Iranian Journal of Microbiology, 2020 Background and Objectives: Coenzyme Q10 is an anti-aging agent whose demand is increasing progressively. There are various strategies used for increasing coenzyme Q10 production by microorganisms.
Foozieh Moghadami, Ramin Hosseini
doaj +1 more source
Effect of Black Sesame Oil Lecithin Solution on Bone Metabolism in Naturally Growing Aged Mice
Liang you shipin ke-ji, 2021 To observe the effect of black sesame oil lecithin solution on bone metabolism in naturally grown aging mice and compare with vitamin E.8-month-old SPF Kunming mice were randomly divided into normal saline group (NS group),vitamin E group (VE group ...
LV Si-min +5 more
doaj +1 more source
Prebiotic Vitamin B$_3$ Synthesis in Carbonaceous Planetesimals [PDF]
ChemPlusChem 2023, e202300508, 2023 Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life.
arxiv +1 more source
Analysis and Suggestions of Evaluation and Approval for Health Foods Containing Coenzyme Q10
Shipin gongye ke-ji, 2022 Coenzyme Q10 is a fat-soluble vitamin-like benzoquinone compound, which is synthesized endogenously from tyrosine in human body. It has many physiological functions, such as participating in ATP production capacity, scavenging free radicals and anti ...
Yu JIANG +4 more
doaj +1 more source
Coenzyme Q10, oxidative stress, and male infertility: A review
Clinical and Experimental Reproductive Medicine, 2021 Male infertility has a complex etiopathology, which mostly remains elusive. Although research has claimed that oxidative stress (OS) is the most likely underlying mechanism of idiopathic male infertility, the specific treatment of OS-mediated male ...
A. Alahmar +5 more
semanticscholar +1 more source
Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10
Journal of Cardiovascular Development and Disease, 2022 Heart failure (HF) is a global epidemic that contributes to the deterioration of quality of life and its shortening in 1–3% of adult people in the world. Pharmacotherapy of HF should rely on highly effective drugs that improve prognosis and prolong life.
Krzysztof J. Filipiak +3 more
doaj +1 more source
Fluorescent redox-dependent labeling of lipid droplets in cultured cells by reduced phenazine methosulfate [PDF]
Heliyon, volume 6, pages e04182, 2020, 2021 Natural and synthetic phenazines are widely used in biomedical sciences. In dehydrogenase histochemistry, phenazine methosulfate (PMS) is applied as a redox reagent for coupling reduced coenzymes to the reduction of tetrazolium salts into colored formazans.
arxiv +1 more source