Results 41 to 50 of about 33,314 (243)

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Effects of Coenzyme Q10 on LDL Oxidation In vitro

Acta Medica Iranica, 2013
Coenzyme Q10, a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. The present study investigated the effects of coenzyme Q10 on in vitro LDL oxidation quantitavely.
Hiroshi Mabuchi, Junji Kobayahi, Masa-aki Kawashiri, Hassan Ahmadvand   +3 more
doaj   +2 more sources

Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse [PDF]

, 2014
Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc.
Alizadeh, Akram., Beigi, Fatemeh., Ketabi, Majid., Mehdizadeh, Mehdi., Niknam Asl, Azadeh., Rigi, Sara., Sakhaei, Abolhassan., Soleimani, Mansooreh.   +7 more
core  

Identification of Coenzyme Q10 and Skeletal Muscle Protein Biomarkers as Potential Factors to Assist in the Diagnosis of Sarcopenia

Antioxidants, 2022
The aim of this study was to explore the use of coenzyme Q10 and skeletal muscle protein biomarkers in the diagnosis of sarcopenia. Subjects with or without sarcopenia were recruited.
Chi-Hua Yen, Po-Sheng Chang, Yu-Hsun Chang, Ping-Ting Lin   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Primary Coenzyme Q10 Deficiency [PDF]

, 2017
open4siCLINICAL CHARACTERISTICS: Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive ...
Doimo, Mara, Navas, P., Salviati, Leonardo, Trevisson, Eva   +3 more
core  

Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation

Health Technology Assessment, 2022
Background: Chronic heart failure is a debilitating condition that accounts for an annual NHS spend of £2.3B. Low levels of endogenous coenzyme Q10 may exacerbate chronic heart failure. Coenzyme Q10 supplements might improve symptoms and slow progression.
Lindsay Claxton, Mark Simmonds, Lucy Beresford, Richard Cubbon, Mark Dayer, Stephen S Gottlieb, Nick Hartshorne-Evans, Bruce Kilroy, Alexis Llewellyn, Claire Rothery, Sahar Sharif, Jayne F Tierney, Klaus K Witte, Kath Wright, Lesley A Stewart   +14 more
doaj   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

In silico analysis of Coenzyme Q10 interaction with the heme-hemoglobin complex: Implications for oxidative stress and inflammation in severe malaria

Advances in Biomarker Sciences and Technology
Background: Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme.
David B. Ouko, Fredrick M. Musila, Peris W. Amwayi, Victoria K. Mwaeni, Dickson B. Kinyanyi, Grace W. Gitau, Alfred Orina Isaac, James Nyabuga Nyariki   +7 more
doaj   +1 more source