Results 21 to 30 of about 17,897 (140)

Neuroprotective effect of hesperidin and its combination with coenzyme Q10 on an animal model of ketamine-induced psychosis: behavioral changes, mitochondrial dysfunctions, and oxidative stress

Future Journal of Pharmaceutical Sciences, 2022
Background Psychosis is a complex mental illness divided by positive symptoms, negative symptoms, and cognitive decline. Clinically available medicines are associated with some serious side effects which limit their use.
Naresh Kumar, Monu Yadav, Anil Kumar, Monika Kadian, Sunil Kumar   +4 more
doaj   +1 more source

Physiological metabolic analysis and process optimization of hypoxia in promoting coenzyme Q10 biosynthesis and accumulation in Rhodobacter sphaeroides HY01

Synthetic and Systems Biotechnology
Coenzyme Q10 fermentation by Rhodobacter sphaeroides (R. sphaeroides) is highly aerobic. However, its biosynthesis and accumulation are paradoxically induced under hypoxic conditions.
Bo Li, Yan Ge, Li Fu, Huanan Guo, Ali Mohsin, Junming Li, Jiequn Wu, Biqin Chen, Yingping Zhuang, Zejian Wang   +9 more
doaj   +1 more source

Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

BMC Cardiovascular Disorders, 2017
Background The therapeutic efficacy of coenzyme Q10 on patients with cardiac failure remains controversial. We pooled previous clinical studies to re-evaluate the efficacy of coenzyme Q10 in patients with cardiac failure.
Li Lei, Yan Liu
doaj   +1 more source

In vitro evaluation of coenzyme Q10 on primary fibroblast culture

Majalah Kedokteran Gigi Indonesia, 2023
Chronic inflammation in periodontitis results in continuous production of Reactive Oxygen Species (ROS), so the levels are excessive, causing destruction of the gingiva, periodontal ligament, and alveolar bone through a variety of mechanisms including ...
Dahlia Herawati
doaj   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Effects of Coenzyme Q10 on LDL Oxidation In vitro

Acta Medica Iranica, 2013
Coenzyme Q10, a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. The present study investigated the effects of coenzyme Q10 on in vitro LDL oxidation quantitavely.
Hiroshi Mabuchi, Junji Kobayahi, Masa-aki Kawashiri, Hassan Ahmadvand   +3 more
doaj   +2 more sources

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation

Health Technology Assessment, 2022
Background: Chronic heart failure is a debilitating condition that accounts for an annual NHS spend of £2.3B. Low levels of endogenous coenzyme Q10 may exacerbate chronic heart failure. Coenzyme Q10 supplements might improve symptoms and slow progression.
Lindsay Claxton, Mark Simmonds, Lucy Beresford, Richard Cubbon, Mark Dayer, Stephen S Gottlieb, Nick Hartshorne-Evans, Bruce Kilroy, Alexis Llewellyn, Claire Rothery, Sahar Sharif, Jayne F Tierney, Klaus K Witte, Kath Wright, Lesley A Stewart   +14 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

In silico analysis of Coenzyme Q10 interaction with the heme-hemoglobin complex: Implications for oxidative stress and inflammation in severe malaria

Advances in Biomarker Sciences and Technology
Background: Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme.
David B. Ouko, Fredrick M. Musila, Peris W. Amwayi, Victoria K. Mwaeni, Dickson B. Kinyanyi, Grace W. Gitau, Alfred Orina Isaac, James Nyabuga Nyariki   +7 more
doaj   +1 more source