A Review of Coformer Utilization in Multicomponent Crystal Formation [PDF]
Molecules, 2022 Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni +4 more
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Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications. [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Maciołek UI +4 more
europepmc +2 more sources
Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals [PDF]
Pharmaceuticals, 2023 The following supporting information can be downloaded at: https://www. mdpi.com/article/10.3390/ph16030370/s1This research was funded by Project B-FQM-478-UGR20 (FEDER-Universidad de Granada, Spain). A.F.
Acebedo Martínez, Francisco Javier +4 more
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Carvedilol solubility enhancement by multicomponent crystallization with coformers of benzoic acid, isonicotinamide, and saccharin [PDF]
Pharmacia, 2023 Multicomponent crystallization is a method that can modify the physicochemical properties of Carvedilol (CVD), thereby increasing its solubility. Based on in silico screening the coformers (Benzoic Acid, Isonicotinamide, and Saccharin) showed non ...
Iyan Sopyan +3 more
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Integrative green synthesis and molecular simulation of ibrutinib cocrystals for enhanced biopharmaceutical performance and in vivo pharmacokinetics. [PDF]
Int J Pharm XBruton's tyrosine kinase (BTK) inhibitor, Ibrutinib (IBR), belongs to class II of the Biopharmaceutics Classification System (BCS). CYP3A4 enzyme forces IBR to have a very limited oral bioavailability.
Kara DD +3 more
europepmc +2 more sources
Apremilast Cocrystals with Phenolic Coformers. [PDF]
MoleculesApremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates the cocrystallization of APR
Naumkina Y +3 more
europepmc +2 more sources
Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis [PDF]
Journal of Chemistry, 2021 Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4 ...
Lei Gao, Xian-Rui Zhang
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Solubility improvement of atorvastatin using deep eutectic solvents. [PDF]
J Adv Pharm Technol ResDeep eutectic solvents (DESs) in pharmaceutical investigations are still largely unknown in terms of safety, environmental acceptability, and practical use.
Wardhana YW +2 more
europepmc +2 more sources
Virtual screening of coformers and solubility test for glibenclamide cocrystallization
National Journal of Physiology, Pharmacy and Pharmacology, 2017 Background: The therapeutic effectiveness of active pharmaceutical ingredients (API) depends on their solubility. API, which has poorly soluble drugs, can cause low bioavailability.
Arif Budiman +2 more
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Enhancing water solubility of phytosterols through Co-amorphization with food-grade coformers. [PDF]
Curr Res Food SciPhytosterols (PS) offer significant health benefits in human diet, but its poor solubility limits its effectiveness and application. This study explored enhancing PS solubility by testing thirteen food-grade coformers, three preparation methods and ...
Li Y +7 more
europepmc +2 more sources