Results 151 to 160 of about 1,361 (189)
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Four cocrystals of thymine with phenolic coformers: influence of the coformer on hydrogen bonding
Acta Crystallographica Section C, Structural Chemistry, 2015Cocrystals are molecular solids composed of at least two types of neutral chemical species held together by noncovalent forces. Crystallization of thymine [systematic name: 5-methylpyrimidine-2,4(1H,3H)-dione] with four phenolic coformers resulted in cocrystal formation,viz.catechol (benzene-1,2-diol) giving thymine–catechol (1/1), C5H6N2O2·C6H6O2, (I),
Jagadeesh Babu Nanubolu +2 more
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Crystal Growth and Design, 2019 Cocrystallization of energetic compounds has recently been considered as an effective method to adjust the properties through the selection of coformers, particularly to improve the detonation properties and reduce the mechanical sensitivity of CL-20. In
Teng Fei, Penghao Lv, Chunlin He
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Journal of Supercritical Fluids, 2020 Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent (SAS) and the cocrystallization with supercritical solvent (CSS) techniques.
Isaac A Cuadra +2 more
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A Coformer Approach for Supramolecular Polymerization at High Concentrations
Angewandte Chemie International Edition, 2023Abstract Insolubility of functional molecules caused by polymorphism sometimes poses limitations for their solution‐based processing. Such a situation can also occur in the preparation processes of supramolecular polymers formed in a solution.
Atsushi Isobe +2 more
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Effects of coformers on phase transformation and release profiles of carbamazepine cocrystals in hydroxypropyl methylcellulose based matrix tablets [PDF]
International Journal of Pharmaceutics, 2015 The aim of this study was to investigate the effects of coformers on phase transformation and release profiles of carbamazepine (CBZ) cocrystals in hydroxypropyl methylcellulose (HPMC) based matrix tablets.
Shi Qiu, Mingzhong Li
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How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability
Chemical Communications, 2016 Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pH(max) above which a less soluble cocrystal becomes more soluble than the drug.
Nair Rodríguez-Hornedo +1 more
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Temozolomide Cocrystals with Carboxamide Coformers
Crystal Growth & Design, 2013Temozolomide (TMZ) is an antitumor prodrug of broad spectrum antineoplastic activity. TMZ is stable in acidic medium (pH 7). In continuation of our efforts to design stable cocrystals of TMZ with partners such as organic acids (pKa 2–5) and a salt dihydrate with hydrochloric acid, we report herein TMZ cocrystals with amide coformers, e.g ...
Palash Sanphui +2 more
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A new polymorph of the common coformer isonicotinamide
CrystEngComm, 2019A polymorph of the widely employed coformer isonicotinamide crystallizing in the space group Pca21 is described for the first time.
Alexios I. Vicatos, Mino R. Caira
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Exploring potential coformers for oxyresveratrol using principal component analysis
International Journal of Pharmaceutics, 2020Oxyresveratrol (OXY) exhibits poor bioavailability due to its low solubility. Cocrystals are effective in improving solubility of OXY. In this study, principal component analysis (PCA) was employed for coformer selection using 5 variables (solubility parameter, logP, hydrogen bonding acceptor, hydrogen bonding donor and molecular volume).
Vimon Tantishaiyakul, Namon Hirun
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