In Silico Coformer Screening for Mefenamic Acid Cocrystallization
Jurnal Info KesehatanCocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Aulia Fikri Hidayat +3 more
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Screening of coformers for quercetin cocrystals through mechanochemical methods
Eclética Química, 2022 Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects.
Fayene Zeferino Ribeiro de Souza +4 more
doaj +4 more sources
Design, characterization, and evaluation of an aceclofenac cocrystal for improved solubility and stability [PDF]
Journal of Applied Pharmaceutical ResearchBackground: Co-crystallization enhances APIs by forming noncovalent interactions with coformers, thereby improving physicochemical properties. Aceclofenac was selected for its low solubility, whereas L-lysine serves as a coformer to enhance solubility ...
Kumar, Aditay, Kumar, Mahesh
core +4 more sources
Machine learning analysis of pharmaceutical cocrystals solubility parameters in enhancing the drug properties for advanced pharmaceutical manufacturing. [PDF]
Sci RepA new computational framework based on machine learning was developed for prediction of Hansen solubility parameters in preparation of pharmaceutical cocrystals with improved properties.
Alharby TN, Huwaimel B.
europepmc +2 more sources
Crystallographic and Computational Analysis of Oxyma B Cocrystals with Nitrogen-Containing Coformers: The Relevant Role of <i>n</i> → π* Interactions in Their Diverse Supramolecular Architectures. [PDF]
Cryst Growth DesJemai M +6 more
europepmc +2 more sources
Cocrystals and Solvates are Not the Same: A Network Perspective. [PDF]
ChemphyschemBased on network analysis, cocrystals and solvates cannot be treated the same. Cocrystals and solvates are two kinds of multicomponent crystals. Cocrystals consist of solid compounds, while solvates consist of a mixture of solid and liquid compounds. This work addresses the question of whether cocrystals and solvates can be treated the same or need to ...
de Vries TE +3 more
europepmc +2 more sources
A Coformer Approach for Supramolecular Polymerization at High Concentrations [PDF]
Angewandte Chemie International Edition, 2023 AbstractInsolubility of functional molecules caused by polymorphism sometimes poses limitations for their solution‐based processing. Such a situation can also occur in the preparation processes of supramolecular polymers formed in a solution. An effective strategy to address this issue is to prepare amorphous solid states by introducing a “coformer ...
Atsushi Isobe +2 more
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Discovering new cocrystals via coformer–network analysis [PDF]
Acta Crystallographica Section A Foundations and Advances, 2018 R. De Gelder +3 more
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CoFormer: Collaborating with Heterogeneous Edge Devices for Scalable Transformer Inference [PDF]
IEEE Transactions on ComputersThe impressive performance of transformer models has sparked the deployment of intelligent applications on resource-constrained edge devices. However, ensuring high-quality service for real-time edge systems is a significant challenge due to the considerable computational demands and resource requirements of these models.
Guanyu Xu +7 more
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Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems
Pharmaceutics, 2023 Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability present a significant challenge during their processing into final dosage forms.
Maan Singh +8 more
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