The 1:1 co-crystal of 2-bromonaphthalene-1,4-dione and 1,8-dihydroxyanthracene-9,10-dione: crystal structure and Hirshfeld surface analysis [PDF]
, 2017 The asymmetric unit of the title co-crystal, C10H5BrO2·C14H8O4 [systematic name: 2-bromo-1,4-dihydronaphthalene-1,4-dione–1,8-dihydroxy-9,10-dihydroanthracene-9,10-dione (1/1)], features one molecule of each coformer.
Garden, Simon J. +5 more
core +6 more sources
Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim
Crystal Growth & Design, 2022 The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH2/N═C/C–NH2 and C–NH2/N═C interaction sites.
Lamis Alaa Eldin Refat +4 more
openalex +4 more sources
Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery
Pharmaceutics, 2022 Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee +6 more
doaj +1 more source
Pre-Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations. [PDF]
Angew Chem Int Ed EnglThe kinetics of mechanochemical reactions can be markedly altered through the selective pre‐activation of starting reagents, as revealed through reaction monitoring using time‐resolved in situ powder X‐ray diffraction and ab initio density functional theory simulation.
Heinekamp C +7 more
europepmc +2 more sources
Co-crystal structures of furosemide:urea and carbamazepine:indomethacin determined from powder x-ray diffraction data [PDF]
, 2020 Co-crystallization is a promising approach to improving both the solubility and the dissolution rate of active pharmaceutical ingredients. Crystal structure determination from powder diffraction data plays an important role in determining co-crystal ...
Al Rahal, Okba +4 more
core +2 more sources
Crystals, 2022 Developing multicomponent crystal forms, especially cocrystals and salts, is becoming a promising pathway to improve the solubility and bioavailability of drugs.
Yujiang Xie +8 more
doaj +1 more source
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
doaj +1 more source
Utilizing hot-stage polarized microscopy and ATR-FTIR for ramipril co-crystal screening, supported by principal component analysis and cluster analysis [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Co-crystal formation, a method for enhancing the physicochemical properties of active pharmaceutical ingredients (APIs), has gained traction in pharmaceutical research. However, the current landscape lacks comprehensive and dependable co-crystal
Indra Indra +5 more
doaj +1 more source
Transformation Pathways of Cocrystal Hydrates When Coformer Modulates Water Activity [PDF]
Journal of Pharmaceutical Sciences, 2010 An important attribute of cocrystals is that their properties can be tailored to meet required solubility and stability specifications. But before such practical uses can be realized, a better understanding of the factors that dictate co-crystal behavior is needed.
Adivaraha Jayasankar +2 more
openalex +5 more sources
Pharmaceutics, 2022 Formation thermodynamic parameters for three cocrystals of carbamazepine (CBZ) with structurally related coformers (benzamide (BZA), para-hydroxybenzamide (4-OH-BZA) and isonicotinamide (INAM)) were determined by experimental (cocrystal solubility and ...
Alex N. Manin +5 more
doaj +1 more source