Results 31 to 40 of about 2,155 (232)

Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method

Crystals, 2020
The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano, Megumi Kitahara, Kae Kishi, Eiichi Goto, Tatsuaki Tagami, Toshiro Fukami, Tetsuya Ozeki   +6 more
doaj   +1 more source

Coformational Switch of Oligonucleotide Induced by Spermine [PDF]

Nucleic Acids Symposium Series, 2005
Conformational change of nucleic acids induced by a small molecule is essential for many biological reactions and useful for biotechnology. To construct a spermine-responsive nucleic acid, we designed DNA sequences which can potentially form a unimolecular hairpin loop structure and a bimolecular duplex by itself.
Toshimasa, Kirihata, Shu-ichi, Nakano, Satoshi, Fujii, Manabu, Matsumoto, Masayasu, Kuwahara, Hiroaki, Sawai, Naoki, Sugimoto   +6 more
openaire   +2 more sources

Differential scanning calorimetry: A screening tool for the development of diacerein eutectics

Results in Chemistry, 2022
The application of DSC technique has been employed for better understanding the behavior of multi-component solid forms of poorly water-soluble drugs. Therefore, the purpose of the present work was to investigate the binary system of Diacerein (DIC) by ...
Rajeshri D. Patel, Mihir K. Raval
doaj   +1 more source

Cocrystallization of acetaminophen and glutaric acid with different coformers [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Recently cocrystallization became a popular tool for crystal engineering that allows, for instance, improving properties of pharmaceutical materials, creating new materials for nonlinear optical applications and solar cell technologies. To attract students to crystallographic studies we carried out project that included crystal growth of two series of ...
Tatiana V. Timofeeva, Sofia Antal, Sergiu Draguta, Karla Ordonez, Raúl Castañeda, Evgeniya S. Leonova   +5 more
openalex   +3 more sources

Coupling complementary strategy to flexible graph neural network for quick discovery of coformer in diverse co-crystal materials

Nature Communications, 2021
Experimental determination of new cocrystals remains challenging due to the need of a systematic screening with a large range of coformers. Here the authors develop a flexible deep learning framework based on graph neural network demonstrated to quickly ...
Yuanyuan Jiang, Zongwei Yang, Jiali Guo, Hongzhen Li, Yijing Liu, Yanzhi Guo, Menglong Li, Xuemei Pu   +7 more
doaj   +1 more source

Cocrystal Formation of Quercetin and Nutraceutical Coformers via a Facile Technique with Improved Solubility and Biological Properties. [PDF]

ACS Omega
Thavornnart P, Chokradjaroen C, Wannarit N, Jiaranaikulwanitch J, Teshima K, Asasutjarit R, Theeramunkong S.   +6 more
europepmc   +2 more sources

Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies [PDF]

, 2016
YesHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT.
Aakeröy, Aitipamula, Aitipamula, Aitipamula, Aitipamula, Animesh Ghosh, Bag, Borba, Braga, C. Malla Reddy, Chadha, Chadha, Chadha, Chan, Clarke, Desiraju, Dolomanov, El-Gizawy, Fandaruff, Ghosh, Ghosh, Ghosh, Gonçalves, Gopi, Gwak, Hancock, Kadam, Khan, Krishna, Leuner, Li, Martins, Mureşan-Pop, Ni, Palatinus, Pires, Qiao, Rajewski, Ramesh Devarapalli, Rao Khandavilli, Rasenack, Remenar, Saha, Sanphui, Sanphui, Sarma, Serajuddin, Sheldrick, Subham Ranjan, Sudeshna Kundu, Swapna, Vangala, Vangala, Vasconcelos, Vasisht, Venu R. Vangala, Vyas, Wang   +57 more
core   +1 more source

Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides

IUCrJ, 2016
A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers.
Geetha Bolla, Ashwini Nangia
doaj   +1 more source

Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals

Pharmaceutics, 2023
In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the successful combination of the drug with the positional isomers of acetamidobenzoic acid.
Artem O. Surov, Anna G. Ramazanova, Alexander P. Voronin, Ksenia V. Drozd, Andrei V. Churakov, German L. Perlovich   +5 more
doaj   +1 more source

Investigation of an amide-pseudo amide hydrogen bonding motif within a series of theophylline:amide cocrystals [PDF]

, 2016
The pharmaceutically active compound theophylline (T) was cocrystallised with the amides formamide (1), acetamide (2), N-methylformamide (3), N,N-dimethylformamide (4), benzamide (5) and pyrazinamide (6), with systems T:1, T:5 and T:6 displaying ...
Davis R. E., Graham J. Tizzard, Laszlo Fábián, Mark D. Eddleston, Mihails Arhangelskis, Simon J. Coles, William Jones   +6 more
core   +3 more sources