Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
doaj +1 more source
Deep Supramolecular Language Processing for Co-Crystal Prediction. [PDF]
Angew Chem Int Ed EnglDeepCocrystal is a deep learning model that predicts co‐crystal formation by learning supramolecular interactions from molecular string representations. It achieves high accuracy, estimates uncertainty, and offers interpretable insights into its predictions. Validated prospectively, DeepCocrystal discovered novel diflunisal co‐crystals and is available
Birolo R +5 more
europepmc +3 more sources
Solvates, salts, and cocrystals : a proposal for a feasible classification system [PDF]
, 2016 The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has led to inconsistent definitions for cocrystals and for ...
De Gelder, R. +4 more
core +2 more sources
Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
doaj +1 more source
Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts [PDF]
, 2017 This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization.
Connor, Lauren E. +5 more
core +1 more source
Cocrystallization of gliclazide with improved physicochemical properties
Future Journal of Pharmaceutical Sciences, 2021 Background Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble.
Shivarani Eesam +3 more
doaj +1 more source
Insight into flufenamic acid cocrystal dissolution in the presence of a polymer in solution: from single crystal to powder dissolution [PDF]
, 2017 Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide ...
Fábián, László +5 more
core +2 more sources
Solubility enhancement of carvedilol by multicomponent crystal approach using glycine and arginine as coformers [PDF]
Pharmacia, 2023 A Carvedilol is a member of BCS class II, it has a low solubility and bioavailability. This work intends to increase the solubility of carvedilol using a multicomponent crystal method.
Iyan Sopyan +3 more
doaj +3 more sources
Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization
Crystal Growth & Design, 2022 Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development. However, it is difficult to know a priori which coformers will form cocrystals with a given API, and the current state-of-the-art for cocrystal discovery involves an expensive, time ...
Isaac J. Sugden +4 more
openaire +2 more sources
Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules. [PDF]
, 2018 Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative ...
Delori, Amit +3 more
core +2 more sources