Crystal structure of the co-crystal O-isopropyl phenylcarbamothioate – 4,4′-bipyridine (2/1), C15H17N2OS [PDF]
, 2018 C15H17N2OS, triclinic, P¯1 (no. 2), a=5.8595(3) Å, b=9.2967(4) Å, c=14.0545(8) Å, α=83.320(4), β= 89.240(4), γ=74.524(4), V =732.71(7) Å3, Z =2, Rgt(F)=0.0458, wRref(F2)=0.1231, T =100 ...
Tiekink, Edward R. T. * +1 more
core +1 more source
Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties [PDF]
, 2014 YesPolymorphism of crystalline drugs is a common phenomenon. However, the number of reported polymorphic cocrystals is very limited. In this work, the synthesis and solid state characterisation of a polymorphic cocrystal composed of sulfadimidine (SD ...
Alhalaweh +42 more
core +1 more source
Site selectivity of halogen oxygen bonding in 5- and 6-haloderivatives of uracil [PDF]
, 2019 Seven 5-and 6-halogenated derivatives of uracil or 1-methyluracil (halogen = Cl, Br, I) were studied by single crystal X-ray diffraction. In contrast with pure 5-halouracils, where the presence of N-H…O and C-H…O hydrogen bonds prevents the formation ...
Portalone, Gustavo
core +1 more source
Overcoming the Drawbacks of Sulpiride by Means of New Crystal Forms [PDF]
, 2022 This study aims at developing new multicomponent crystal forms of sulpiride, an antipsychotic drug. The main goal was to improve its solubility since it belongs to class IV of the BCS. Nine new adducts were obtained by combining the active pharmaceutical
Bacchi, Alessia +8 more
core +2 more sources
Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials. [PDF]
, 2014 Mechanochemistry deals with reactions induced by the input of mechanical energy - for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday ...
Eddleston, Mark D, Jones, William
core +1 more source
Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide [PDF]
, 2021 Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD).
Lorenz, H. +2 more
core +2 more sources
Crystal structure of the (E)-O-methyl-N-phenyl-thiocarbamate – 4,4′-bipyridine (1/1), C18H17N3OS [PDF]
, 2018 C18H17N3OS, monoclinic, C2/c (no. 15), a=13.4754(3) Å, b=13.8997(3) Å, c=18.0300(4) Å, β=107.202(3)°, V =3226.03(13) Å3, Z =8, Rgt(F)=0.0341, wRref(F2)=0.0878, T =100(2 ...
Tiekink, Edward R. T. * +1 more
core +1 more source
Crystals, 2018 The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal engineering that has emerged as a promising technique for drug development in pharmaceutical industry.
Ranjit Thakuria, Bipul Sarma
doaj +1 more source
Halogen Bond-Driven Ligand Displacement: Co-Crystal Lattice Versus Coordination Bonds. [PDF]
ChemistryStrong halogen bond donor (1,4‐diiodotetrafluorobenzene) can induce the amine ligand displacement in Jahn–Teller affected Cu(acac)2(amine) and in trans influenced VO(acac)2(amine) complexes, resulting the formation of respective co‐crystals: M(acac)2·1,4‐DITFB and (amine)·1,4‐DITFB.
Torubaev YV +3 more
europepmc +2 more sources
Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals
Angewandte Chemie International Edition, EarlyView.Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley +1 more source