Results 31 to 40 of about 3,623 (177)

A multi-step pathway for the establishment of sister chromatid cohesion.

PLoS Genetics, 2007
The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood.
Mark Milutinovich, Elçin Unal, Chris Ward, Robert V Skibbens, Douglas Koshland   +4 more
doaj   +1 more source

Unique organization and unprecedented diversity of the Bacteroides (Pseudobacteroides) cellulosolvens cellulosome system

Biotechnology for Biofuels, 2017
Background (Pseudo) Bacteroides cellulosolvens is an anaerobic, mesophilic, cellulolytic, cellulosome-producing clostridial bacterium capable of utilizing cellulose and cellobiose as carbon sources. Recently, we sequenced the B.
Olga Zhivin, Bareket Dassa, Sarah Moraïs, Sagar M. Utturkar, Steven D. Brown, Bernard Henrissat, Raphael Lamed, Edward A. Bayer   +7 more
doaj   +1 more source

The Cellulosome Paradigm in An Extreme Alkaline Environment

Microorganisms, 2019
Rapid decomposition of plant biomass in soda lakes is associated with microbial activity of anaerobic cellulose-degrading communities. The alkaliphilic bacterium, Clostridium alkalicellulosi, is the single known isolate from a soda lake that demonstrates
Paripok Phitsuwan, Sarah Moraïs, Bareket Dassa, Bernard Henrissat, Edward A. Bayer   +4 more
doaj   +1 more source

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization [PDF]

Nature Structural & Molecular Biology, 2018
Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types. We report here their genomic distribution and specific contributions to genome organization in human cells.
Kojic, Aleksandar, Cuadrado, Ana, De Koninck, Magali, Giménez-Llorente, Daniel, Rodríguez-Corsino, Miriam, Gómez-López, Gonzalo, Le Dily, François, Marti-Renom, Marc A, Losada, Ana, Losada, Ana   +9 more
openaire   +3 more sources

Differential cohesin loading marks paired and unpaired regions of platypus sex chromosomes at prophase I

Scientific Reports, 2017
Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and ...
Aaron E. Casey, Tasman J. Daish, Jose Luis Barbero, Frank Grützner   +3 more
doaj   +1 more source

A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans.

PLoS ONE, 2011
The cohesin complex is required for the cohesion of sister chromatids and for correct segregation during mitosis and meiosis. Crossover recombination, together with cohesion, is essential for the disjunction of homologous chromosomes during the first ...
Antoine Baudrimont, Alexandra Penkner, Alexander Woglar, Yasmine M Mamnun, Margot Hulek, Cathrin Struck, Ralf Schnabel, Josef Loidl, Verena Jantsch   +8 more
doaj   +1 more source

Minimalistic Cellulosome of the Butanologenic Bacterium Clostridium saccharoperbutylacetonicum

mBio, 2020
Clostridium saccharoperbutylacetonicum is a mesophilic, anaerobic, butanol-producing bacterium, originally isolated from soil. It was recently reported that C. saccharoperbutylacetonicum possesses multiple cellulosomal elements and would potentially form
Bosmat Levi Hevroni, Sarah Moraïs, Yonit Ben-David, Ely Morag, Edward A. Bayer   +4 more
doaj   +1 more source

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis

Cell Reports, 2019
Summary: Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis
Covadonga Vara, Andreu Paytuví-Gallart, Yasmina Cuartero, François Le Dily, Francisca Garcia, Judit Salvà-Castro, Laura Gómez-H, Eva Julià, Catia Moutinho, Riccardo Aiese Cigliano, Walter Sanseverino, Oscar Fornas, Alberto M. Pendás, Holger Heyn, Paul D. Waters, Marc A. Marti-Renom, Aurora Ruiz-Herrera   +16 more
doaj   +1 more source

Mechanical disengagement of the cohesin ring

Nature Structural & Molecular Biology, 2023
AbstractCohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping DNA and counteracting the forces generated by the mitotic spindle. Whether individual cohesins encircle both sister DNAs and how cohesin opposes spindle-generated forces remains unknown.
Martina Richeldi, Georgii Pobegalov, Torahiko L. Higashi, Karolina Gmurczyk, Frank Uhlmann, Maxim I. Molodtsov   +5 more
openaire   +3 more sources

Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes.

PLoS Genetics, 2014
Cohesins are important for chromosome structure and chromosome segregation during mitosis and meiosis. Cohesins are composed of two structural maintenance of chromosomes (SMC1-SMC3) proteins that form a V-shaped heterodimer structure, which is bridged by
Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Steve Murray, Philip W Jordan   +8 more
doaj   +1 more source