Results 21 to 30 of about 3,623 (177)
Crosstalk between chromatin structure, cohesin activity and transcription
Epigenetics & Chromatin, 2019 Background A complex interplay between chromatin and topological machineries is critical for genome architecture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism ...
Douglas Maya-Miles +8 more
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Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes
eLife, 2014 We show that multiple, functionally specialized cohesin complexes mediate the establishment and two-step release of sister chromatid cohesion that underlies the production of haploid gametes. In C.
Aaron F Severson, Barbara J Meyer
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Bioinformatical analysis of eukaryotic shugoshins reveals meiosis-specific features of vertebrate shugoshins [PDF]
PeerJ, 2016 Background Shugoshins (SGOs) are proteins that protect cohesins located at the centromeres of sister chromatids from their early cleavage during mitosis and meiosis in plants, fungi, and animals.
Tatiana M. Grishaeva +2 more
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Surveillance of cohesin-supported chromosome structure controls meiotic progression
Nature Communications, 2020 Meiosis-specific cohesins and the synaptonemal complex are essential for meiotic chromosome structure and function. Here the authors show that continued surveillance of these chromosome structures controls meiotic progression by regulating CHK-2, a ...
Maikel Castellano-Pozo +6 more
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Cohesin loading and sliding [PDF]
Journal of Cell Science, 2011 Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division.
Maria T, Ocampo-Hafalla, Frank, Uhlmann
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Age-related decrease of meiotic cohesins in human oocytes.
PLoS ONE, 2014 Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age.
Makiko Tsutsumi +9 more
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Cohesin architecture and clustering in vivo
eLife, 2021 Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains ...
Siheng Xiang, Douglas Koshland
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Chromatin insulators and cohesins [PDF]
The EMBO Reports, 2008 Chromatin insulators have evolved to regulate transcription by using regulatory elements that are often distant from each other on the linear genome. This feature is position‐dependent—that is, a functional insulator must be positioned between the enhancer and its target promoter (Wallace & Felsenfeld, 2007).
Anita, Göndör, Rolf, Ohlsson
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Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L
G3: Genes, Genomes, Genetics, 2016 Cohesin is an essential structural component of chromosomes that ensures accurate chromosome segregation during mitosis and meiosis. Previous studies have shown that there are cohesin complexes specific to meiosis, required to mediate homologous ...
Ayobami Ward +4 more
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A folded conformation of MukBEF and Cohesin [PDF]
Nature Structural & Molecular Biology, 2018 Abstract Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, where they have key roles in chromosome segregation, DNA repair and regulation of gene expression. They function through topological entrapment and active translocation of DNA, but the underlying conformational ...
Frank Bürmann +9 more
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