Results 1 to 10 of about 3,623 (177)

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner [PDF]

Nature Communications
Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer.
Cosetta Bertoli, Robertus De Bruin, Peter Thorpe   +2 more
exaly   +3 more sources

Aberrant cohesin function in Saccharomyces cerevisiae activates Mcd1 degradation to promote cell lethality. [PDF]

PLoS Genetics
The cohesin complex is composed of core ring proteins (Smc1, Smc3 and Mcd1) and associated factors (Pds5, Scc3, and Rad61) that bind via Mcd1. Extrusion (looping from within a single DNA molecule) and cohesion (the tethering together of two different DNA
Gurvir Singh, Robert V Skibbens
doaj   +2 more sources

Insights into lignocellulose degradation: comparative genomics of anaerobic and cellulolytic Ruminiclostridium-type species [PDF]

Frontiers in Microbiology, 2023
Mesophilic, anaerobic, and cellulolytic Ruminiclostridium-type bacterial species can secrete an extracellular, multi-enzyme machinery cellulosome, which efficiently degrades cellulose.
Mengcheng You, Mengcheng You, Qiuyun Zhao, Yuansheng Liu, Yuansheng Liu, Wenhao Zhang, Wenhao Zhang, Zhewei Shen, Zhenxing Ren, Chenggang Xu   +9 more
doaj   +2 more sources

Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase

PLoS Genetics, 2020
During meiotic prophase, sister chromatids are organized into axial element (AE), which underlies the structural framework for the meiotic events such as meiotic recombination and homolog synapsis.
Kunihiro Ohta, Kimi Araki, Hiroki Shibuya   +2 more
exaly   +2 more sources

Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora. [PDF]

PLoS Genetics
Faithful chromosome segregation during meiosis requires the coordinated action of cohesin complexes and chromosome axis proteins. How these factors interact and communicate along chromosome axes, especially during meiotic prophase I, remains however ...
Kenza Yefsah, Marwan Habbi, Karine Budin, Henri-Marc Bourbon, Denise Zickler, Eric Espagne, Stéphanie Boisnard   +6 more
doaj   +2 more sources

Cohesin protein Smc3 influences kinocilial structure and function [PDF]

Biology Open
Fiona M. Mensching, Niusha Banoukh, M. Kathryn Iovine   +2 more
doaj   +2 more sources

Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells [PDF]

Scientific Reports
Cohesin and condensin, two related protein complexes, play essential roles in ensuring the accurate segregation of the genome into daughter cells during cell division. However, the interaction between cohesin and condensin in embryonic stem cells remains
Eui-Hwan Choi, Keun P. Kim
doaj   +2 more sources

Spatial Chromatin Organization Across the Cell Cycle: Insights from Auxin-Inducible Protein Depletion [PDF]

Cells
Many cellular processes, including gene expression regulation, DNA replication and repair, as well as proper condensation and segregation of chromosomes, require highly coordinated remodeling of chromatin.
Artem Nurislamov, Anastasia Yunusova
doaj   +2 more sources

Rules of engagement for condensins and cohesins guide mitotic chromosome formation [PDF]

Science
Kumiko Samejima, Job Dekker, Leonid A Mirny   +2 more
exaly   +3 more sources

CTCF, Cohesin, and Chromatin in Human Cancer [PDF]

Genomics & Informatics, 2017
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex.
Sang-Hyun Song, Tae-You Kim
doaj   +1 more source