Results 141 to 150 of about 5,258,967 (252)

Institutional conflicts of interest in health-related research - a scoping review. [PDF]

Res Integr Peer Rev
Haarmann A, Kugler CM, Goodarzi H, Pachanov A, Goossen K, Akl EA, Pieper D.   +6 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Developing an Early Childhood Environmental Health Vulnerability Index to Assess Cumulative Health Impacts Across Contiguous US. [PDF]

Geohealth
Liu S, Yang A, Horm D, Zhu M, Cai C.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Corrigendum to "A methodology for determining dosing recommendations for anticancer drugs in patients with reduced kidney function". [PDF]

EClinicalMedicine
Sandhu G, Gordon EA, Adattini J, O'Neill N, Chambers P, Johnson DW, Kelly A, Liauw W, Mallett AJ, Michael M, Mirkov S, Scuderi C, Shingleton J, Siderov J, Sprangers B, Stein BN, Tunnicliffe DJ, Ward RL, ADDIKD Working Group.   +18 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Predictors, prevalence and economic burden of depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia: protocol for an integrative review. [PDF]

BMJ Open
Donnelly TT, Vu TP, Nguyen TMH, Nguyen QG, Tran NK, Le HHB, Tang DM.   +6 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Development of the First Cytochrome Oxidase I Barcode and Evidence for a Dominant Variant Associated with the Recent United States Invasion of the Pasture Mealybug <i>Heliococcus summervillei</i> (Hemiptera: Pseudococcidae) Complex. [PDF]

Insects
Ahmed MZ, Tan P, Yadav N, Hauxwell C, Kerns DL, Wilson B, Quinn N, Esquivel IL, Rustgi S, Hernandez-Europa Y, Patrick D.   +10 more
europepmc   +1 more source