Results 191 to 200 of about 5,258,967 (252)

Peer victimization, school belonging, and epigenetic aging among children of Latino immigrants. [PDF]

Child Dev
Alvarado-Harris R, Perreira KM.
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Sociodemographic Predictors of Postpresentation Delay to Pediatric ACL Reconstruction and Associated Intra-articular Injury Severity. [PDF]

Am J Sports Med
Hamad CD, Wu S, Joachim K, Chung E, Liu T, Silva M, Bowen R, Baghdadi S.   +7 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Interfacial Stabilization of Li_1.3Al_0.3Ti_1.7(PO₄)₃ Solid Electrolytes Enabled by a Sulfone-Based Crystalline Organic Interlayer. [PDF]

Chemphyschem
Han S, Zhu L, Yu M, Tang W, Chen J.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

COI Barcoding Unveils Hidden Fish Diversity and Potential Cryptic Lineages in Inner Mongolia, China. [PDF]

Ecol Evol
Zhao Y, Wang M, Liu Z, Yu J, Ma K, Si X, Zhang M, Qiu S, Li Y, Wang C, Tang Y, Guo B, Li X, Zhou C.   +13 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Genetic insights into the non-indigenous copepod <i>Pseudodiaptomus marinus</i> Sato, 1913 (Calanoida: Pseudodiaptomidae) in the Mediterranean Sea. [PDF]

PeerJ
Di Capua I, Piredda R, Amato A, Camatti E, Carotenuto Y, Corona S, D'Angiolo R, Marcucci A, Goruppi A, Tirelli V, Zagami G, Uttieri M.   +11 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source