Results 221 to 230 of about 5,258,967 (252)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Classification of outcomes in antimalarial therapeutic efficacy studies with Aster. [PDF]

Antimicrob Agents Chemother
Gerlovina I, Berube S, Briggs J, Murie K, Murphy M, Wesolowski A, Greenhouse B.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enriched neighborhood environments relate to episodic memory through prefrontal rather than medial temporal pathways during late childhood and early adolescence. [PDF]

Brain Environ
Rosario MA, Cardenas-Iniguez C, Chavez JV, Bottenhorn K, Ahmadi H, Herting MM, Thompson WK.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Systematic Review of Anchored and Unanchored EB-FRP Systems for Tension Strengthening of Concrete Structures. [PDF]

Polymers (Basel)
Zhang J, Castillo EDR, Sadegh Salimian Rizi M, Yu T.   +3 more
europepmc   +1 more source

Construction of a COI DNA barcode reference library for non-volant terrestrial mammals of Taiwan, with notes on the effects of nuclear mitochondrial pseudogenes (numts) on molecular identification. [PDF]

Zookeys
Chen YJ, Chiang YL, Chi MJ, Chang SW, Jang-Liaw NH.   +4 more
europepmc   +1 more source

Citizen Sailors Provide a Detailed Map of Open-Ocean Surface Biodiversity and Help Link eDNA Data to Satellite Observations. [PDF]

Mol Ecol
Saenz-Agudelo P, Laroche O, Knight B, Bomati E, Pochon X.   +4 more
europepmc   +1 more source

Longitudinal Surveillance of Invasive Mosquitoes at Points of Entry in Northeastern Italy. [PDF]

Trop Med Infect Dis
Manzi S, Micocci M, Tassoni L, Vettore S, Bonetto D, Martini S, Gradoni F, Toniolo F, Iandiorio G, Danca LI, Chiarello G, Visentin P, Cecconello M, Carlin S, Gobbo F, Mazzucato M, Russo F, Ziprani C, Bucci B, Iavicoli S, Severino V, Montarsi F.   +21 more
europepmc   +1 more source