PrfH accelerates repair of colicin E3 - damaged translating ribosomes by RtcB2 [PDF]
RNA BiologyColicin E3 (E3-rRNAse) abolishes protein biosynthesis in bacteria by cleaving 16S rRNA in the decoding centre. The RtcB2-PrfH 16S rRNA repair module prevents cellular death upon exposure to E3-rRNAse in E. coli.
Tinashe P. Maviza +9 more
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Assessment of resistance to colicinogenic synthetic phage antimicrobial system [PDF]
Microbiology SpectrumThis work presents a multi-hurdle approach that addresses antimicrobial resistance by minimizing the selective pressure of antimicrobials using a novel colicinogenic–phage system.
Meghan McGillin +3 more
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Binding Free Energy Analysis of Colicin D, E3 and E8 to Their Respective Cognate Immunity Proteins Using Computational Simulations [PDF]
MoleculesColicins are antimicrobial proteins produced by bacteria for the purpose of destroying neighboring bacteria. Colicin activity is neutralized by a specific cognate immunity protein in order to protect the host.
Mahesh Koirala, Clifton K. Fagerquist
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Microorganisms, 2022 Due to the spread of antibiotic-resistant bacteria, new alternatives to antibiotics and ways to prevent infections are being sought. Bacteriocin-producing bacteria are therefore attracting attention due to their probiotic potential as a safe alternative ...
Marina V. Kuznetsova +3 more
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Unique activity spectrum of colicin FY: all 110 characterized Yersinia enterocolitica isolates were colicin FY susceptible. [PDF]
PLoS ONE, 2013 Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia.
Juraj Bosák +6 more
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In vivo processing of DNase colicins E2 and E7 is required for their import into the cytoplasm of target cells. [PDF]
PLoS ONE, 2014 DNase colicins E2 and E7, both of which appropriate the BtuB/Tol translocation machinery to cross the outer membrane, undergo a processing step as they enter the cytoplasm. This endoproteolytic cleavage is essential for their killing action.
Liliana Mora, Miklos de Zamaroczy
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Colicin E2 expression in Escherichia coli biofilms: Induction and regulation revisited
Current Research in Microbial Sciences, 2022 Colicins, bacteriocins produced by the gram-negative bacterium Escherichia coli, are tightly regulated by the DNA damage response regulatory system (SOS), and are thus triggered at times of stress.
Bihter Bayramoglu-Güven +3 more
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Colicin E1 opens its hinge to plug TolC
eLife, 2022 The double membrane architecture of Gram-negative bacteria forms a barrier that is impermeable to most extracellular threats. Bacteriocin proteins evolved to exploit the accessible, surface-exposed proteins embedded in the outer membrane to deliver ...
S Jimmy Budiardjo +9 more
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Deciphering the Role of Colicins during Colonization of the Mammalian Gut by Commensal E. coli
Microorganisms, 2020 Colicins are specific and potent toxins produced by Enterobacteriaceae that result in the rapid elimination of sensitive cells. Colicin production is commonly found throughout microbial populations, suggesting its potential importance for bacterial ...
Amanda N. Samuels +5 more
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mSphere, 2022 Novel approaches to combating antibiotic resistance are needed given the ever-continuing rise of antibiotic resistance and the scarce discovery of new antibiotics.
Marlène Maeusli +14 more
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