Results 11 to 20 of about 55,191 (217)
Antibiotics, 2022 Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin.
Yi-Yun Liu +8 more
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2021 Background: Antimicrobial resistance to colistin, a widely used feed additive for farm animals across the world, has raised public health concern in recent years.
Kohei Makita +2 more
exaly +3 more sources
PLoS ONE, 2022 Emerging resistance to colistin in Acinetobacter baumannii clinical strains is concerning because of the limited therapeutic choices for these important clinical pathogens.
Mashal M. Almutairi
doaj +3 more sources
Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate [PDF]
Journal of Antimicrobial Chemotherapy, 2004 To determine the disposition of colistin methanesulphonate (CMS) and colistin following intravenous (iv) administration of CMS in rats.Five rats received a single iv bolus of 15 mg/kg CMS. Plasma concentrations of CMS and of colistin formed by the hydrolysis of CMS were determined by HPLC.
Li, J. +5 more
openaire +4 more sources
Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]
Scientific Reports, 2017 AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young +2 more
openaire +4 more sources
Colistin Dependency among Colistin-Heteroresistant Acinetobacter baumannii Isolates
Microorganisms, 2021 Colistin dependent (CD) isolates are dependent on colistin for optimal growth. Here we aimed to systematically determine the emergence of CD among colistin-heteroresistant carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. We also examined the
Hadas Kon +6 more
doaj +2 more sources
Risk factors of colistin safety according to administration routes: Intravenous and aerosolized colistin. [PDF]
PLoS ONE, 2018 BACKGROUND:Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk
Kyoung Lok Min +5 more
doaj +3 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: Colistin is a ‘last-line’ antibiotic used to treat multidrug-resistant Gram-negative bacteria, but colistin resistance has emerged. Colistin normally binds to the lipid A moiety on the bacterial outer membrane, where it then destroys the ...
James Olson, Douglas Call
exaly +3 more sources
Heterogeneous Colistin-Resistance Phenotypes Coexisting in Stenotrophomonas maltophilia Isolates Influence Colistin Susceptibility Testing [PDF]
Frontiers in Microbiology, 2018 The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed.
Sònia Martínez-Servat +11 more
doaj +2 more sources
Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor-Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment. [PDF]
Adv Sci (Weinh)This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhang Z +8 more
europepmc +2 more sources