Antibiotics, 2022 Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin.
Yi-Yun Liu +8 more
doaj +2 more sources
Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate [PDF]
Journal of Antimicrobial Chemotherapy, 2004 To determine the disposition of colistin methanesulphonate (CMS) and colistin following intravenous (iv) administration of CMS in rats.Five rats received a single iv bolus of 15 mg/kg CMS. Plasma concentrations of CMS and of colistin formed by the hydrolysis of CMS were determined by HPLC.
Li, J. +5 more
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PLoS ONE, 2022 Emerging resistance to colistin in Acinetobacter baumannii clinical strains is concerning because of the limited therapeutic choices for these important clinical pathogens.
Mashal M. Almutairi
doaj +3 more sources
Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]
Scientific Reports, 2017 AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young +2 more
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Colistin Dependency among Colistin-Heteroresistant Acinetobacter baumannii Isolates
Microorganisms, 2021 Colistin dependent (CD) isolates are dependent on colistin for optimal growth. Here we aimed to systematically determine the emergence of CD among colistin-heteroresistant carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. We also examined the
Hadas Kon +6 more
doaj +2 more sources
Risk factors of colistin safety according to administration routes: Intravenous and aerosolized colistin. [PDF]
PLoS ONE, 2018 BACKGROUND:Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk
Kyoung Lok Min +5 more
doaj +3 more sources
Heterogeneous Colistin-Resistance Phenotypes Coexisting in Stenotrophomonas maltophilia Isolates Influence Colistin Susceptibility Testing [PDF]
Frontiers in Microbiology, 2018 The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed.
Sònia Martínez-Servat +11 more
doaj +2 more sources
Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates. However, in the last few years, colistin-resistant A. baumannii and K.
Rafael Ayerbe-Algaba +2 more
exaly +2 more sources
Clinical Microbiology and Infection, 2012 At present, colistin is among the few antibiotics effective against Acinetobacter baumannii clinical isolates. However, in the last few years, colistin-resistant A. baumannii strains have been isolated.
Jeronimo Pachón +2 more
exaly +2 more sources
Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats [PDF]
Benha Veterinary Medical Journal, 2023 Colistin, a glycopeptide antibiotic, is only used as an emergency treatment in case of multidrug-resistant bacterial infections. Due to its propensity for causing nephrotoxicity, colistin has a limited range of applications.
Hoda Khallaf +2 more
doaj +1 more source