Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]
Scientific Reports, 2017 AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young +2 more
openaire +4 more sources
Colistin Dependency among Colistin-Heteroresistant Acinetobacter baumannii Isolates
Microorganisms, 2021 Colistin dependent (CD) isolates are dependent on colistin for optimal growth. Here we aimed to systematically determine the emergence of CD among colistin-heteroresistant carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. We also examined the
Hadas Kon +6 more
doaj +2 more sources
Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate [PDF]
Journal of Antimicrobial Chemotherapy, 2004 To determine the disposition of colistin methanesulphonate (CMS) and colistin following intravenous (iv) administration of CMS in rats.Five rats received a single iv bolus of 15 mg/kg CMS. Plasma concentrations of CMS and of colistin formed by the hydrolysis of CMS were determined by HPLC.
Li, J. +5 more
openaire +4 more sources
Risk factors of colistin safety according to administration routes: Intravenous and aerosolized colistin. [PDF]
PLoS ONE, 2018 BACKGROUND:Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk
Kyoung Lok Min +5 more
doaj +3 more sources
Presence of Colistin- and Tigecycline-Resistant Klebsiella pneumoniae ST29 in Municipal Wastewater Influents in Japan [PDF]
, 2021 The aim of this study was to investigate the presence of colistin- and/or tigecycline-resistant Klebsiella spp. in influents from four wastewater treatment plants (WWTPs), which partly reflect the gut microbiome of human populations.
Nagano, Yukiko +8 more
core +1 more source
A Clinico-Microbiological Study of Blood Stream Infections in a Tertiary Referral Hospital: Colistin Resistance & Challenges [PDF]
, 2023 Carbapenems, frequently used for the treatment of infections caused by Multidrug-resistant (MDR) Gram-negative bacteria (GNB) are being reported with increased resistance rate.
Jyoti Chaudhary +2 more
core +1 more source
Adsorption-desorption and degradation of colistin in soils under aerobic conditions
Ecotoxicology and Environmental Safety, 2022 Colistin has broad-spectrum activity against Gram-negative bacteria and has been considered as the last-resort treatment for multiantibiotic-resistant Gram-negative bacteria infections in human.
Lijuan Peng +3 more
doaj +1 more source
PLoS ONE, 2020 Long-term use of colistin for preventing Gram-negative bacterial infections in food animals was prohibited in Thailand in 2017, but it is permitted for short-term treatment.
Pariwat Poolperm +4 more
doaj +1 more source
Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains [PDF]
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2017 Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported.
Deniz GAZEL, Müşerref TATMAN OTKUN
doaj +1 more source
International Journal of Infectious Diseases, 2021 Objective: To compare the effectiveness and safety of aerosolized (AER) plus intravenous (IV) colistin with IV colistin alone in patients with nosocomial pneumonia (NP) due to multidrug-resistant (MDR) Gram-negative bacteria.
Thamer A. Almangour +9 more
doaj +1 more source