Results 21 to 30 of about 40,207 (173)

Colistin

Reactions Weekly, 2015
Colistin (polymyxin E) is a positively charged deca-peptide antibiotic that disrupts the integrity of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A moiety of lipopolysaccharides, resulting in cell death. The endotoxic activity of lipopolysaccharides is simultaneously inhibited.
Dijkmans, Anneke C., Wilms, Erik B., Kamerling, Ingrid M. C., Birkhoff, Willem, Ortiz-Zacarias, Natalia V., van Nieuwkoop, Cees, Verbrugh, Henri A., Touw, Daan J.   +7 more
  +6 more sources

Old drug, new findings: colistin resistance and dependence of [PDF]

Precision and Future Medicine, 2017
Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii.
Kwan Soo Ko, Yujin Choi, Ji-Young Lee
doaj   +1 more source

Colistin Dependency among Colistin-Heteroresistant Acinetobacter baumannii Isolates

Microorganisms, 2021
Colistin dependent (CD) isolates are dependent on colistin for optimal growth. Here we aimed to systematically determine the emergence of CD among colistin-heteroresistant carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. We also examined the
Hadas Kon, Amichay Hameir, Elizabeth Temkin, Alona Keren-Paz, David Schwartz, Vered Schechner, Yehuda Carmeli   +6 more
doaj   +1 more source

Assessment of colistin resistance in Gram negative bacteria from clinical samples in resource-limited settings

Asian Pacific Journal of Tropical Medicine, 2022
Objective: To find a proper method to assess colistin resistance in multidrug resistant Gram negative bacteria (MDR-GNB) on a routine basis in resource limited settings. Methods: Clinical samples were processed.
Shubham Chauhan, Narinder Kaur, Adesh K Saini, Jyoti Chauhan, Harit Kumar   +4 more
doaj   +1 more source

Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii

Microbiology Spectrum, 2022
Colistin, which targets lipopolysaccharide (LPS), is used as a last-resort drug against severe infections caused by drug-resistant Acinetobacter baumannii. However, A. baumannii possesses two colistin-resistance mechanisms.
Go Kamoshida, Noriteru Yamada, Tomoka Nakamura, Daiki Yamaguchi, Daichi Kai, Maho Yamashita, Chiaki Hayashi, Nana Kanda, Moe Sakaguchi, Hitoshi Morimoto, Teppei Sawada, Tomoko Okada, Yuki Kaya, Norihiko Takemoto, Kinnosuke Yahiro   +14 more
doaj   +1 more source

Role of efflux pumps, their inhibitors, and regulators in colistin resistance

Frontiers in Microbiology, 2023
Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding, Jingchen Hao, Weijia Xiao, Caihong Ye, Xue Xiao, Chunxia Jian, Min Tang, Guangrong Li, Jinbo Liu, Zhangrui Zeng   +9 more
doaj   +1 more source

The effectiveness and nephrotoxicity of loading dose colistin combined with or without meropenem for the treatment of carbapenem-resistant A. baumannii

International Journal of Infectious Diseases, 2020
Introduction: Acinetobacter baumannii has emerged as an important nosocomial pathogen worldwide. In Thailand, the incidence and mortality rate of carbapenem-resistant A. baumannii (CRAB) is continuously increasing. This organism is a common pathogen that
Wasan Katip, Suriyon Uitrakul, Peninnah Oberdorfer   +2 more
doaj   +1 more source

Development of colistin resistance via heteroresistance modeling in : A diagnostic study [PDF]

Precision and Future Medicine
Purpose Colistin heteroresistance mediates the failure of antibiotic treatments, is prone to lead to colistin resistance, and has been frequently reported in Klebsiella pneumoniae.
Jungyu Seo, Kwan Soo Ko
doaj   +1 more source

Treatment outcome and adverse effects of colistin in adult patients with carbapenem-resistant gram-negative bacteremia from Pakistan

International Journal of Infectious Diseases, 2021
Background: Polymyxins (colistin) have emerged for the treatment of carbapenem resistant (CR) gram-negative infections. There is a paucity of data on treatment outcomes and adverse effects of high-dose colistin treatment in Pakistan.
Zaheer Udin Babar, Sunil Kumar Dodani, Asma Nasim   +2 more
doaj   +1 more source

Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections

Scientific Reports, 2021
Development of an effective therapy to overcome colistin resistance in Klebsiella pneumoniae, a common pathogen causing catheter-related biofilm infections in vascular catheters, has become a serious therapeutic challenge that must be addressed urgently.
Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Paul G. Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Naphat Chantaravisoot, Thammakorn Saethang, Sirirat Luk-in, Tingting Liao, Sumanee Nilgate, Ubolrat Rirerm, Naris Kueakulpattana, Matchima Laowansiri, Sukrit Srisakul, Netchanok Muhummudaree, Teerasit Techawiwattanaboon, Lin Gan, Chenchen Xu, Rosalyn Kupwiwat, Phatthranit Phattharapornjaroen, Rojrit Rojanathanes, Asada Leelahavanichkul, Tanittha Chatsuwan   +23 more
doaj   +1 more source