Results 21 to 30 of about 20,481 (152)

Colistin-phage combinations decrease antibiotic resistance in Acinetobacter baumannii via changes in envelope architecture

, 2021
Multidrug-resistant bacterial infections are becoming increasingly common, with only few last-resort antibiotics such as colistin available for clinical therapy.
Xiaoting Hua (435699), Xiaoqing Wang (514179), Belinda Loh (3596981), Yunsong Yu (496103), Fernando Gordillo Altamirano (11792613), Sebastian Leptihn (2189809)   +5 more
core   +1 more source

Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant Escherichia coli, In Vitro and in a Murine Peritonitis Model

Antibiotics, 2023
Colistin is a drug of last resort to treat extreme drug-resistant Enterobacterales, but is limited by dose-dependent toxicity and the emergence of resistance.
Samuel Chosidow, Bruno Fantin, Irène Nicolas, Jean-Baptiste Mascary, Françoise Chau, Valérie Bordeau, Marie-Clemence Verdier, Pierre Rocheteau, Francois Guérin, Vincent Cattoir, Victoire de Lastours   +10 more
doaj   +1 more source

Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa

International Journal of Infectious Diseases, 2020
Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa. Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital referral laboratory between 2016 ...
Yolandi Snyman, Andrew Christopher Whitelaw, Sandra Reuter, Angela Dramowski, Motlatji Reratilwe Bonnie Maloba, Mae Newton-Foot   +5 more
doaj   +1 more source

Assessment of the Synergistic Effect of Seven Antimicrobial Combinations on Extensively Drug-Resistant Acinetobacter baumannii Strains

Annals of Clinical Microbiology, 2022
Background: To solve the difficulty in determining the appropriate treatment regimen for patients infected with extensively drug-resistant Acinetobacter baumannii (XDRAB), it is necessary to develop various strategies to increase the therapeutic effect ...
Choon-Mee Kim, Young-Jin Ko, Ji Ae Choi, Seong-Ho Kang, Geon Park, Sook-Jin Jang   +5 more
doaj   +1 more source

Old drug, new findings: colistin resistance and dependence of [PDF]

Precision and Future Medicine, 2017
Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii.
Kwan Soo Ko, Yujin Choi, Ji-Young Lee
doaj   +1 more source

Assessment of colistin resistance in Gram negative bacteria from clinical samples in resource-limited settings

Asian Pacific Journal of Tropical Medicine, 2022
Objective: To find a proper method to assess colistin resistance in multidrug resistant Gram negative bacteria (MDR-GNB) on a routine basis in resource limited settings. Methods: Clinical samples were processed.
Shubham Chauhan, Narinder Kaur, Adesh K Saini, Jyoti Chauhan, Harit Kumar   +4 more
doaj   +1 more source

Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii

Microbiology Spectrum, 2022
Colistin, which targets lipopolysaccharide (LPS), is used as a last-resort drug against severe infections caused by drug-resistant Acinetobacter baumannii. However, A. baumannii possesses two colistin-resistance mechanisms.
Go Kamoshida, Noriteru Yamada, Tomoka Nakamura, Daiki Yamaguchi, Daichi Kai, Maho Yamashita, Chiaki Hayashi, Nana Kanda, Moe Sakaguchi, Hitoshi Morimoto, Teppei Sawada, Tomoko Okada, Yuki Kaya, Norihiko Takemoto, Kinnosuke Yahiro   +14 more
doaj   +1 more source

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019

, 2020
To investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014 ...
Rong Zhang (44942), Edward Wai-Chi Chan (4356652), Qiaoling Sun (738882), Jiayue Lu (8376588), Sheng Chen (21971), Ning Dong (340660), Hong Huang (119275), Lingbin Shu (8376585)   +7 more
core   +1 more source

Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals. [PDF]

, 2019
BACKGROUND: New antibiotics are urgently needed for the treatment of multidrug resistant infections. However, the production of novel antibiotics is diminishing.
Tryfinopoulou, K, Hu, Y, Colistin - Azidothymidine Hellenic Study Group, Voulgaris, GL, Kyriakidou, M, Vatopoulos, A, Falagas, ME, Giakkoupi, P, Coates, A   +8 more
core   +1 more source

Role of efflux pumps, their inhibitors, and regulators in colistin resistance

Frontiers in Microbiology, 2023
Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding, Jingchen Hao, Weijia Xiao, Caihong Ye, Xue Xiao, Chunxia Jian, Min Tang, Guangrong Li, Jinbo Liu, Zhangrui Zeng   +9 more
doaj   +1 more source