Results 11 to 20 of about 2,359,106 (231)

MCR: modern colistin resistance [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2017
Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This
Caniaux, I., Gros, M. F., Zambardi, G., Belkum, A. van, Poirel, Laurent   +4 more
core   +7 more sources

Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131Research in context [PDF]

EBioMedicine
Summary: Background: Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence ...
Toyotaka Sato, Soh Yamamoto, Jirachaya Toyting-Hiraishi, Mana Tohyama, Masaru Usui, Hiharu Inoue, Noriko Ogasawara, Yoshinori Ikenaka, Wataru Hayashi, Hidetaka Kosako, Masato Suzuki, Noriyuki Nagano, Takayuki Wada, Chie Nakajima, Yasuhiko Suzuki, Motohiro Horiuchi, Satoshi Takahashi, Shin-ichi Yokota, Yutaka Tamura   +18 more
doaj   +2 more sources

Colistin Resistance in Bacteria: Current Updates on Mechanism of Action and Combating Strategies [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology
The rapid development of colistin-resistant bacteria is the biggest global health issue since colistin is referred to as a ‘last-hope resource’ against life-threatening infections caused by GNB (Gram-negative bacteria). Injudicious and excessive colistin
Indu Singh, Anil Kumar, Indira Kumari Verma, Divakar Sharma, Amritesh Kumar Singh   +4 more
doaj   +2 more sources

Heterogeneous Colistin-Resistance Phenotypes Coexisting in Stenotrophomonas maltophilia Isolates Influence Colistin Susceptibility Testing [PDF]

Frontiers in Microbiology, 2018
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed.
Sònia Martínez-Servat, Sònia Martínez-Servat, Daniel Yero, Daniel Yero, Pol Huedo, Pol Huedo, Roser Marquez, Gara Molina, Xavier Daura, Xavier Daura, Isidre Gibert, Isidre Gibert   +11 more
doaj   +3 more sources

Colistin Resistance Development Following Colistin-Meropenem Combination Therapy vs. Colistin Monotherapy in Patients with Infections Caused by Carbapenem-Resistant Organisms

Clinical Infectious Diseases, 2020
We evaluated whether carbapenem-colistin combination therapy given to patients with infections due to carbapenem-resistant Gram-negative organisms reduces the emergence of colistin resistance compared to colistin ...
Yahav, Dafna, GIURAZZA, ROBERTO, Mouton, Johan, Dickstein, Y, Bernardo, Mariano, Benattar, YD, Antoniadou, Anastasia, Antoniadou, A, Altunin, S, Rakovitsky, Nadya, Skiada, A, Altunin, Sergey, Carmeli, Y, Schwartz, David, Deliolanis, I, Rognås, Viktor, Daitch, V, Leibovici, L, Daitch, Vered, Mouton, Johan W, Paul, Mical, Rognas, V, Leibovici, Leonard, Durante-Mangoni, E, Dishon Benattar, Yael, Daikos, GL, Carmeli, Yehuda, Skiada, Anna, Paul, M, Lellouche, Jonathan, Rakovitsky, N, Lellouche, J, Nutman, Amir, Yahav, D, Dickstein, Yaakov, Deliolanis, Ioannis, Daikos, George L, Iossa, Domenico, Durante-Mangoni, Emanuele, Friberg, Lena E, Bernardo, M, Iossa, D, Friberg, LE, Schwartz, D, Nutman, A, Friberg, Lena E.,, Rognås, Viktor,   +46 more
core   +4 more sources

Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli

Journal of Global Antimicrobial Resistance
Objectives: The mechanisms underlying chromosomally encoded colistin resistance in Escherichia coli remain insufficiently investigated. In this study, we investigated the contribution of various pmrB mutations from E.
Jung-Chung Lin, Leung-Kei Kristopher Siu, Feng-Yee Chang, Ching-Hsun Wang   +3 more
doaj   +2 more sources

Adaptive colistin resistance dynamics in mcr-9-positive and -negative Enterobacterales following low-level colistin exposure [PDF]

Microbiology Spectrum
The mcr-9 gene has been reported across different sources and was recognized as a potential contributor to increased minimum inhibitory concentrations after colistin exposure. This study aimed to determine the prevalence of intestinal carriage of the mcr-
Eva Smelikova, Marie Brajerova, Jan Tkadlec, Pavel Drevinek, Marcela Krutova   +4 more
doaj   +2 more sources

Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Under the Pressure of Tigecycline

Frontiers in Microbiology, 2021
Colistin and tigecycline are the last options against carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Intersecting resistance determinants have been detected between these antibiotics; however, there is only limited evidence of such ...
Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, Hui Wang   +7 more
doaj   +1 more source

Role of efflux pumps, their inhibitors, and regulators in colistin resistance

Frontiers in Microbiology, 2023
Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding, Jingchen Hao, Weijia Xiao, Caihong Ye, Xue Xiao, Chunxia Jian, Min Tang, Guangrong Li, Jinbo Liu, Zhangrui Zeng   +9 more
doaj   +1 more source

Decreased colistin resistance and mcr-1 prevalence in pig-derived Escherichia coli in Japan after banning colistin as a feed additive

Journal of Global Antimicrobial Resistance, 2021
Background: Antimicrobial resistance to colistin, a widely used feed additive for farm animals across the world, has raised public health concern in recent years.
Masaru Usui, Yohei Nozawa, Akira Fukuda, Tomomi Sato, Michi Yamada, Kohei Makita, Yutaka Tamura   +6 more
doaj   +1 more source