Results 11 to 20 of about 33,514 (181)

Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]

Scientific Reports, 2017
AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young, Chung, Eun Seon, Ko, Kwan Soo   +2 more
openaire   +3 more sources

MCR: modern colistin resistance [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2016
Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This may ultimately render the "last resort" polymyxin antibiotics therapeutically useless.
Caniaux I, van Belkum A, Zambardi G, Poirel L, Gros MF   +4 more
openaire   +4 more sources

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

mSphere, 2020
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of ...
Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik   +6 more
doaj   +1 more source

Circumventing colistin resistance by combining colistin and antimicrobial peptides to kill colistin-resistant and multidrug-resistant Gram-negative bacteria

Journal of Global Antimicrobial Resistance, 2020
Colistin is a 'last-line' antibiotic used to treat multidrug-resistant Gram-negative bacteria, but colistin resistance has emerged. Colistin normally binds to the lipid A moiety on the bacterial outer membrane, where it then destroys the bacterial membrane.
Kaitlin S. Witherell, Jason Price, Ashok D. Bandaranayake, James Olson, Douglas R. Call   +4 more
openaire   +3 more sources

An overview of colistin resistance, mobilized colistin resistance genes dissemination, global responses, and the alternatives to colistin: A review [PDF]

Veterinary World, 2019
Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide dissemination of colistin-resistance has brought strong attention to the scientific society because of its importance as the last resort for the treatment of carbapenem-
Mohammad H. Gharaibeh, Shoroq Q. Shatnawi   +1 more
openaire   +3 more sources

Mobile colistin resistance (mcr) genes and recent developments in colistin resistance detection

Letters in Applied Microbiology, 2023
Abstract The peptide antibiotic colistin has been reserved as a last resort antibiotic treatment option for cases where other antibiotics including carbapenems have failed. Recent emergence of colistin resistance and discovery of mobile colistin resistance (mcr) genes, which encode the cell wall modifying phosphoethanolamine transferase ...
Divya Lakshmanan, Dhamodharan Ramasamy, Veni Subramanyam, Suresh Kumar Saravanan   +3 more
openaire   +2 more sources

Transcriptomic analysis of colistin-susceptible and colistin-resistant isolates identifies genes associated with colistin resistance in Acinetobacter baumannii [PDF]

Clinical Microbiology and Infection, 2015
The emergence of colistin-resistant Acinetobacter baumannii is concerning, as colistin is often regarded as the last option for treating multidrug-resistant (MDR) A. baumannii infections. Using mRNA sequencing, we compared whole transcriptomes of colistin-susceptible and colistin-resistant A.
Park, Y.K., Lee, J.-Y., Ko, K.S.
openaire   +2 more sources

Synergistic Effects of Capric Acid and Colistin against Colistin-Susceptible and Colistin-Resistant Enterobacterales

Antibiotics, 2022
Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin. In this study, synergy between colistin and capric acid was examined against twenty-one Gram-negative bacterial isolates (four colistin-susceptible and seventeen colistin ...
Yi-Yun Liu, Zong-Hua Qin, Hui-Ying Yue, Phillip J. Bergen, Li-Min Deng, Wan-Yun He, Zhen-Ling Zeng, Xian-Feng Peng, Jian-Hua Liu   +8 more
openaire   +3 more sources

Colistin Resistance among Enterobacterales Isolates: Underlying Mechanisms and Alternative Treatment Options

Journal of Pure and Applied Microbiology, 2023
Global dissemination of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria (GNB) such as carbapenemase-producing Enterobacterales has resulted in reviving colistin as a final therapeutic alternative. Colistin resistance
Amal F. Makled, Sahar A.M. Ali, Ahmed B. Mahmoud, Marwa E. Eltoukhy, Reem M. Elkholy, Athar F. Lasheen, Asmaa Mohammed Elbrolosy   +6 more
doaj   +1 more source

Prevalence of colistin resistance of Klebsiella pneumoniae isolates in Iran: a systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Objective Klebsiella pneumoniae is a gram-negative pathogen common cause of nosocomial infections. Colistin is a last resort antibiotic to treat infections caused by K. pneumoniae.
Negar Narimisa, Forough Goodarzi, Shirin Bavari   +2 more
doaj   +1 more source