Results 11 to 20 of about 57,221 (225)

Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018) [PDF]

Microorganisms, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat.
Elbediwi, Mohammed, Fang, Weihuan, Feng, Youjun, Li, Xiaoliang, Li, Yan, Pan, Hang, Paudyal, Narayan, Rajkovic, Andreja, Rankin, Shelley C., Xie, Shaohua, Yue, Min   +10 more
core   +8 more sources

The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges

Microorganisms, 2021
Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ...
Mouna Hamel, Jean-Marc Rolain, Sophie Alexandra Baron   +2 more
doaj   +3 more sources

MCR: modern colistin resistance [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2016
Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This may ultimately render the "last resort" polymyxin antibiotics therapeutically useless.
Caniaux, I., Belkum, A. van, Zambardi, G., Poirel, Laurent, Gros, M. F.   +4 more
openaire   +2 more sources

Deciphering MCR-2 Colistin Resistance [PDF]

mBio, 2017
ABSTRACT Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem ...
Jian Sun, Yongchang Xu, Rongsui Gao, Jingxia Lin, Wenhui Wei, Swaminath Srinivas, Defeng Li, Run-Shi Yang, Xing-Ping Li, Xiao-Ping Liao, Ya-Hong Liu, Youjun Feng   +11 more
openaire   +3 more sources

A Resistance Mechanism in Non-mcr Colistin-Resistant Escherichia coli in Taiwan: R81H Substitution in PmrA Is an Independent Factor Contributing to Colistin Resistance

Microbiology Spectrum, 2021
Colistin resistance due to the mcr-type genes in Escherichia coli is well characterized. In order to study the resistance mechanism in mcr-negative colistin-resistant E.
Ching-Hsun Wang, L. Kristopher Siu, Feng-Yee Chang, Sheng-Kang Chiu, Jung-Chung Lin   +4 more
doaj   +1 more source

Mobile colistin resistance (mcr) genes and recent developments in colistin resistance detection

Letters in Applied Microbiology, 2023
Abstract The peptide antibiotic colistin has been reserved as a last resort antibiotic treatment option for cases where other antibiotics including carbapenems have failed. Recent emergence of colistin resistance and discovery of mobile colistin resistance (mcr) genes, which encode the cell wall modifying phosphoethanolamine transferase ...
Divya Lakshmanan, Dhamodharan Ramasamy, Veni Subramanyam, Suresh Kumar Saravanan   +3 more
openaire   +2 more sources

A link between pH homeostasis and colistin resistance in bacteria

Scientific Reports, 2021
Colistin resistance is complex and multifactorial. DbcA is an inner membrane protein belonging to the DedA superfamily required for maintaining extreme colistin resistance of Burkholderia thailandensis. The molecular mechanisms behind this remain unclear.
Pradip R. Panta, William T. Doerrler
doaj   +1 more source

Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]

Scientific Reports, 2017
AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young, Chung, Eun Seon, Ko, Kwan Soo   +2 more
openaire   +3 more sources

Potential dietary feed additives with antibacterial effects and their impact on performance of weaned piglets: A meta-analysis [PDF]

, 2019
This meta-analysis evaluated the use of potential dietary feed additives (pDFA) with antibacterial effects and their impact on the perfomance of weaned piglets.
Bruggeman, G., Dewulf, J., Papadopoulos, D., Sarrazin, S., Tanghe, S., Trevisi, P., Vanrolleghem, W., Verstringe, S., Zentek, J.   +8 more
core   +5 more sources

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

mSphere, 2020
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of ...
Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik   +6 more
doaj   +1 more source