Results 21 to 30 of about 2,218,812 (219)
Combination of Colistin and Azidothymidine Demonstrates Synergistic Activity against Colistin-Resistant, Carbapenem-Resistant Klebsiella pneumoniae [PDF]
Microorganisms, 2020 Carbapenem-resistant Enterobacteriaceae (CRE) is listed as an urgent threat by the World Health Organization because of the limited therapeutic options, rapid evolution of resistance mechanisms, and worldwide dissemination. Colistin is a common backbone agent among the “last-resort” antibiotics for CRE; however, its emerging resistance among CRE has ...
Ya-Ting Chang +7 more
openaire +4 more sources
Journal of Global Antimicrobial ResistanceObjectives: The mechanisms underlying chromosomally encoded colistin resistance in Escherichia coli remain insufficiently investigated. In this study, we investigated the contribution of various pmrB mutations from E.
Jung-Chung Lin +3 more
doaj +2 more sources
Evolution of colistin resistance in Acinetobacter baumannii and disrupting the colistin resistance mechanisms [PDF]
This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University ...
Gadar, Kavita
core +6 more sources
Frontiers in Microbiology, 2021 Colistin and tigecycline are the last options against carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Intersecting resistance determinants have been detected between these antibiotics; however, there is only limited evidence of such ...
Yawei Zhang +7 more
doaj +1 more source
Role of efflux pumps, their inhibitors, and regulators in colistin resistance
Frontiers in Microbiology, 2023 Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr and chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However,
Yinhuan Ding +9 more
doaj +1 more source
A Clinico-Microbiological Study of Blood Stream Infections in a Tertiary Referral Hospital: Colistin Resistance & Challenges [PDF]
, 2023 Carbapenems, frequently used for the treatment of infections caused by Multidrug-resistant (MDR) Gram-negative bacteria (GNB) are being reported with increased resistance rate.
Jyoti Chaudhary +2 more
core +1 more source
Emerging Microbes and Infections, 2021 Infections caused by extensively drug-resistant (XDR) Acinetobacter nosocomialis have become a challenging problem. The frequent use of colistin as the last resort drug for XDR bacteria has led to the emergence of colistin-resistant A.
Ya-Sung Yang +10 more
doaj +1 more source
Asian Pacific Journal of Tropical Medicine, 2022 Objective: To find a proper method to assess colistin resistance in multidrug resistant Gram negative bacteria (MDR-GNB) on a routine basis in resource limited settings. Methods: Clinical samples were processed.
Shubham Chauhan +4 more
doaj +1 more source
Colistin Resistance in Gram-Negative Bacteria: Mechanisms, Transmission, and Novel Intervention Strategies. [PDF]
MicroorganismsMultidrug resistance (MDR) in Gram-negative bacteria is a global issue and needs to be addressed urgently. MDR can emerge through genetic mutations and horizontal gene transfer and deteriorate under antibiotic selective pressure.
Zeb S +9 more
europepmc +2 more sources
Transition of colistin dependence into colistin resistance in Acinetobacter baumannii [PDF]
Scientific Reports, 2017 AbstractWe recently demonstrated a high rate of colistin dependence in Acinetobacter baumannii isolates exposed to colistin in vitro. In the present study, we obtained a colistin-resistant (H08-391R) and colistin-dependent mutant (H08-391D) from a colistin-susceptible parental strain (H08-391). We found that the colistin-dependent mutant converted into
Lee, Ji-Young +2 more
openaire +3 more sources