Results 21 to 30 of about 33,804 (189)

Colistin Resistance among Enterobacterales Isolates: Underlying Mechanisms and Alternative Treatment Options

Journal of Pure and Applied Microbiology, 2023
Global dissemination of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria (GNB) such as carbapenemase-producing Enterobacterales has resulted in reviving colistin as a final therapeutic alternative. Colistin resistance
Amal F. Makled, Sahar A.M. Ali, Ahmed B. Mahmoud, Marwa E. Eltoukhy, Reem M. Elkholy, Athar F. Lasheen, Asmaa Mohammed Elbrolosy   +6 more
doaj   +1 more source

Combinations of colistin and bacteriocins prevent the selection of colistin resistance in Acinetobacter baumannii. [PDF]

Commun Biol
Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen responsible for infections that are often difficult to treat. Here, we show that exposure of A. baumannii to the last-resort antibiotic colistin, which disrupts the outer membrane of Gram-negative bacteria, results in inner membrane permeabilization and depolarization, ultimately ...
Rubio T, Zur Nedden T, Zedek S, Raoux-Bardot D, Cottineau C, Belot L, Raynaud C, Oms T, Rodriguez-Vilallobos H, Jurenas D, Chenal A, Van Melderen L.   +11 more
europepmc   +3 more sources

New Mutations Involved in Colistin Resistance in Acinetobacter baumannii

mSphere, 2020
Colistin is used as the “last resort” to treat infections caused by multidrug-resistant Acinetobacter baumannii, which is at the top of the World Health Organization’s list of the most dangerous bacterial species that threaten human health. Unfortunately,
Bingbing Sun, Haiyan Liu, Yu Jiang, Lei Shao, Sheng Yang, Daijie Chen   +5 more
doaj   +1 more source

Prevalence of colistin resistance of Klebsiella pneumoniae isolates in Iran: a systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Objective Klebsiella pneumoniae is a gram-negative pathogen common cause of nosocomial infections. Colistin is a last resort antibiotic to treat infections caused by K. pneumoniae.
Negar Narimisa, Forough Goodarzi, Shirin Bavari   +2 more
doaj   +1 more source

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2017
Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported.
Deniz GAZEL, Müşerref TATMAN OTKUN
doaj   +1 more source

Plasmid-mediated mcr-1 colistin resistance in Escherichia coli and Klebsiella spp. clinical isolates from the Western Cape region of South Africa

Antimicrobial Resistance and Infection Control, 2017
Background Colistin is a last resort antibiotic for the treatment of carbapenem-resistant Gram negative infections. Until recently, mechanisms of colistin resistance were limited to chromosomal mutations which confer a high fitness cost and cannot be ...
Mae Newton-Foot, Yolandi Snyman, Motlatji Reratilwe Bonnie Maloba, Andrew Christopher Whitelaw   +3 more
doaj   +1 more source

Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018) [PDF]

Microorganisms, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways ...
Mohammed Elbediwi, Yan Li, Narayan Paudyal, Hang Pan, Xiaoliang Li, Shaohua Xie, Andreja Rajkovic, Youjun Feng, Weihuan Fang, Shelley C. Rankin, Min Yue   +10 more
openaire   +4 more sources

Evaluation of Plasmid Mediated Colistin Resistance in Colistin Resistant Gram-negative Bacilli

Journal of Kermanshah University of Medical Sciences, 2023
Background: Infections caused by carbapenem-resistant gram-negative bacteria are treated with colonistin as a last resort. However, the increased resistance in recent years is significant for treating multiple drug-resistant infections. Objectives: This study aimed to determine the resistance genes mobile colistin resistance (mcr)-1 and mcr-2 in the ...
Yeliz Tanriverdi Cayci, Kubra Hacieminoglu Ulker, Demet Gur Vural, Kemal Bilgin, Asuman Birinci   +4 more
openaire   +1 more source

Colistin: A mainstay antibiotic for treatment of fatal Gram negative bacterial infections [PDF]

ERU Research Journal
Our world is facing an enormous disaster due to spreading of the life-threatening bacterial infections, especially after the spread of multidrug-resistant Gram-negative bacteria (MDR-GNB), including those resistant to known antibiotics such as ...
Ahmed El-Khatib, Ahmed Basyony
doaj   +1 more source

Deciphering MCR-2 Colistin Resistance [PDF]

mBio, 2017
ABSTRACT Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem ...
Jian Sun, Yongchang Xu, Rongsui Gao, Jingxia Lin, Wenhui Wei, Swaminath Srinivas, Defeng Li, Run-Shi Yang, Xing-Ping Li, Xiao-Ping Liao, Ya-Hong Liu, Youjun Feng   +11 more
openaire   +3 more sources