Results 21 to 30 of about 33,514 (181)

Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa

Journal of Global Antimicrobial Resistance, 2021
: Objectives: Colistin resistance in Acinetobacter spp. is increasing, resulting in potentially untreatable nosocomial infections. Plasmid-mediated colistin resistance is of particular concern due to its low fitness cost and potential transferability to
Yolandi Snyman, Sandra Reuter, Andrew Christopher Whitelaw, Lisa Stein, Motlatji Reratilwe Bonnie Maloba, Mae Newton-Foot   +5 more
doaj   +1 more source

New Mutations Involved in Colistin Resistance in Acinetobacter baumannii

mSphere, 2020
Colistin is used as the “last resort” to treat infections caused by multidrug-resistant Acinetobacter baumannii, which is at the top of the World Health Organization’s list of the most dangerous bacterial species that threaten human health. Unfortunately,
Bingbing Sun, Haiyan Liu, Yu Jiang, Lei Shao, Sheng Yang, Daijie Chen   +5 more
doaj   +1 more source

Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2017
Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported.
Deniz GAZEL, Müşerref TATMAN OTKUN
doaj   +1 more source

Plasmid-mediated mcr-1 colistin resistance in Escherichia coli and Klebsiella spp. clinical isolates from the Western Cape region of South Africa

Antimicrobial Resistance and Infection Control, 2017
Background Colistin is a last resort antibiotic for the treatment of carbapenem-resistant Gram negative infections. Until recently, mechanisms of colistin resistance were limited to chromosomal mutations which confer a high fitness cost and cannot be ...
Mae Newton-Foot, Yolandi Snyman, Motlatji Reratilwe Bonnie Maloba, Andrew Christopher Whitelaw   +3 more
doaj   +1 more source

Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018) [PDF]

Microorganisms, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways ...
Mohammed Elbediwi, Yan Li, Narayan Paudyal, Hang Pan, Xiaoliang Li, Shaohua Xie, Andreja Rajkovic, Youjun Feng, Weihuan Fang, Shelley C. Rankin, Min Yue   +10 more
openaire   +4 more sources

Evaluation of Plasmid Mediated Colistin Resistance in Colistin Resistant Gram-negative Bacilli

Journal of Kermanshah University of Medical Sciences, 2023
Background: Infections caused by carbapenem-resistant gram-negative bacteria are treated with colonistin as a last resort. However, the increased resistance in recent years is significant for treating multiple drug-resistant infections. Objectives: This study aimed to determine the resistance genes mobile colistin resistance (mcr)-1 and mcr-2 in the ...
Yeliz Tanriverdi Cayci, Kubra Hacieminoglu Ulker, Demet Gur Vural, Kemal Bilgin, Asuman Birinci   +4 more
openaire   +1 more source

Risk Factors for the Development of Colistin Resistance during Colistin Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections

Microbiology Spectrum, 2022
Colistin is one of the last-resort options for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections if novel antibiotics are unavailable, where the development of colistin resistance during treatment represents a major challenge for clinicians ...
Po-Han Huang, Wen-Yin Chen, Sheng-Hua Chou, Fu-Der Wang, Yi-Tsung Lin   +4 more
doaj   +1 more source

Deciphering MCR-2 Colistin Resistance [PDF]

mBio, 2017
ABSTRACT Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem ...
Jian Sun, Yongchang Xu, Rongsui Gao, Jingxia Lin, Wenhui Wei, Swaminath Srinivas, Defeng Li, Run-Shi Yang, Xing-Ping Li, Xiao-Ping Liao, Ya-Hong Liu, Youjun Feng   +11 more
openaire   +3 more sources

Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years

Brazilian Journal of Infectious Diseases, 2017
Colistin resistance involving Gram-negative bacilli infections is a challenge for health institutions around of the world. Carbapenem-resistance among these isolates makes colistin the last therapeutic option for this treatment. Colistin resistance among
Flávia Rossi, Raquel Girardello, Ana Paula Cury, Thais Sabato Romano Di Gioia, João Nóbrega de Almeida, Jr, Alberto José da Silva Duarte   +5 more
doaj   +1 more source

Colistin: A mainstay antibiotic for treatment of fatal Gram negative bacterial infections [PDF]

ERU Research Journal
Our world is facing an enormous disaster due to spreading of the life-threatening bacterial infections, especially after the spread of multidrug-resistant Gram-negative bacteria (MDR-GNB), including those resistant to known antibiotics such as ...
Ahmed El-Khatib, Ahmed Basyony
doaj   +1 more source