Results 61 to 70 of about 32,247 (189)

Clinical Use of Colistin Induces Cross-Resistance to Host Antimicrobials in Acinetobacter baumannii

mBio, 2013
The alarming rise in antibiotic resistance has led to an increase in patient mortality and health care costs. This problem is compounded by the absence of new antibiotics close to regulatory approval.
Brooke A. Napier, Eileen M. Burd, Sarah W. Satola, Stephanie M. Cagle, Susan M. Ray, Patrick McGann, Jan Pohl, Emil P. Lesho, David S. Weiss   +8 more
doaj   +1 more source

Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii

Microbiology Spectrum, 2022
Colistin, which targets lipopolysaccharide (LPS), is used as a last-resort drug against severe infections caused by drug-resistant Acinetobacter baumannii. However, A. baumannii possesses two colistin-resistance mechanisms.
Go Kamoshida, Noriteru Yamada, Tomoka Nakamura, Daiki Yamaguchi, Daichi Kai, Maho Yamashita, Chiaki Hayashi, Nana Kanda, Moe Sakaguchi, Hitoshi Morimoto, Teppei Sawada, Tomoko Okada, Yuki Kaya, Norihiko Takemoto, Kinnosuke Yahiro   +14 more
doaj   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian, Nipit Tangchitnob   +1 more
wiley   +1 more source

Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains

Medical Science and Discovery, 2018
Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment.
openaire   +3 more sources

Outer membrane permeability of mcr-positive bacteria reveals potent synergy of colistin and macromolecular antibiotics against colistin-resistant Acinetobacter baumannii

Frontiers in Microbiology
Colistin (CT) is the last-resort of antibiotic against multidrug-resistance (MDR) Acinetobacter baumannii (A. baumannii) infection. However, colistin resistance is increasingly reported in A.
Meisong Li, Furong Ma, Hui Zhao, Dianrong Zhou, Dianrong Zhou, Dianrong Zhou, Lujie Liang, Lujie Liang, Lujie Liang, Runling Lv, Jiachen Li, Jiachen Li, Jiachen Li, Yaxuan Wang, Yaxuan Wang, Yaxuan Wang, Lin Xu, Lin Xu, Lin Xu, Chenfei Liu, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Siyuan Feng, Siyuan Feng, Siyuan Feng, Yong Xia   +26 more
doaj   +1 more source

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source

Plasmid-mediated colistin resistance: an additional antibiotic resistance menace [PDF]

Clinical Microbiology and Infection, 2016
The increasing trend in antibiotic resistance continues to threaten global health due to the limited pipeline of new antibiotics. Multidrug resistance in Gram-negative bacteria is of special concern because it may associate resistance to the three main classes of antibiotics in single isolates.
Nordmann, Patrice, Poirel, Laurent
openaire   +3 more sources

Prevalence of colistin-resistant Enterobacteriaceae isolated from clinical samples in Africa: a systematic review and meta-analysis

BMC Infectious Diseases
Background Antimicrobial resistance among Enterobacteriaceae poses a significant global threat, particularly in developing countries. Colistin, a critical last-resort treatment for infections caused by carbapenem-resistant and multidrug-resistant strains,
Yalewayker Gashaw, Zelalem Asmare, Mitkie Tigabie, Asefa Sisay, Ermias Getatachew, Selamyhun Tadesse, Getachew Bitew, Agenagnew Ashagre, Tadesse Misganaw, Muluken Gashaw, Woldeteklehaymanot Kassahun, Zelalem Dejazimach, Abdu Jemal, Solomon Gedfie, Getinet Kumie, Marye Nigatie, Wagaw Abebe, Atitegeb Abera Kidie, Biruk Beletew Abate, Melese Abate Reta, Baye Gelaw   +20 more
doaj   +1 more source

Prevalence of colistin-resistant Escherichia coli in foods and food-producing animals through the food chain: A worldwide systematic review and meta-analysis

Heliyon
The purpose of this systematic review and meta-analysis was to summarize the available scientific evidence on the prevalence of colistin-resistant Escherichia coli strains isolated from foods and food-producing animals, the mobile colistin-resistant ...
Florencia Aylen Lencina, Matías Bertona, María Angeles Stegmayer, Carolina Raquel Olivero, Laureano Sebastián Frizzo, Jorge Alberto Zimmermann, Marcelo Lisandro Signorini, Lorena Paola Soto, María Virginia Zbrun   +8 more
doaj   +1 more source

Characteristics and genomic epidemiology of colistin-resistant Enterobacterales from farmers, swine, and hospitalized patients in Thailand, 2014–2017

BMC Infectious Diseases, 2023
Background Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics.
Adhiratha Boonyasiri, Lauren M. Brinkac, Elita Jauneikaite, Richard C. White, Chris Greco, Chakkraphong Seenama, Teerawit Tangkoskul, Kevin Nguyen, Derrick E. Fouts, Visanu Thamlikitkul   +9 more
doaj   +1 more source