Results 51 to 60 of about 5,247 (206)

Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults

open access: yesImmunity, Inflammation and Disease, 2022
Background Surfactant Protein D (SP‐D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs.
Benjamin Hoffmann‐Petersen   +8 more
doaj   +1 more source

3D‐printing of Methacryloylated Recombinant Collagen for Tissue Engineering

open access: yesChemistrySelect, Volume 11, Issue 17, 5 May 2026.
Recombinant collagen‐like proteins offer promise as alternatives to mammalian collagens. There is less risk of disease transfer, and changes in structure can be readily introduced. Here, a recombinant collagen‐like protein was methacryloylated for extrusion printing and rapid photo‐crosslinking.
Malachy K. Maher   +7 more
wiley   +1 more source

The Role of Humoral Innate Immunity in Hepatitis C Virus Infection

open access: yesViruses, 2012
Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed.
Richard A. Urbanowicz   +2 more
doaj   +1 more source

Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

open access: yesFrontiers in Immunology, 2021
Human SP-D is a potent innate immune molecule whose presence at pulmonary mucosal surfaces allows its role in immune surveillance against pathogens. Higher levels of serum SP-D have been reported in the patients with severe acute respiratory syndrome ...
Miao-Hsi Hsieh   +13 more
doaj   +1 more source

Arg343 in Human Surfactant Protein D Governs Discrimination between Glucose and N-Acetylglucosamine Ligands [PDF]

open access: yes, 2004
Surfactant protein D (SP-D), one of the members of the collectin family of C-type lectins, is an important component of pulmonary innate immunity. SP-D binds carbohydrates in a calcium-dependent manner, but the mechanisms governing its ligand recognition
Allen, Martin   +5 more
core   +3 more sources

Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells

open access: yesFrontiers in Immunology, 2020
Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain.
Valarmathy Murugaiah   +13 more
doaj   +1 more source

S-nitrosylation of surfactant protein-D controls inflammatory function. [PDF]

open access: yesPLoS Biology, 2008
The pulmonary collectins, surfactant proteins A and D (SP-A and SP-D) have been implicated in the regulation of the innate immune system within the lung. In particular, SP-D appears to have both pro- and anti-inflammatory signaling functions. At present,
Chang-Jiang Guo   +8 more
doaj   +1 more source

In vivo clearance of surfactant lipids during acute pulmonary inflammation. [PDF]

open access: yes, 2004
Background A decrease in pulmonary surfactant has been suggested to contribute to the lung dysfunction associated with pulmonary inflammation. A number of studies have implicated surfactant clearance as a possible mechanism for altered pool sizes.
J Goerke   +26 more
core   +2 more sources

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo   +33 more
wiley   +1 more source

Comparative Genomics of Pinna rudis and Pinna nobilis Reveals Conserved and Divergent Features of the Bivalve Defensome

open access: yesEcology and Evolution, Volume 16, Issue 3, March 2026.
We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé   +6 more
wiley   +1 more source

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