Results 31 to 40 of about 5,247 (206)

The Role of Collectins and Galectins in Lung Innate Immune Defense

Frontiers in Immunology, 2018
Different families of endogenous lectins use complementary defense strategies against pathogens. They may recognize non-self glycans typically found on pathogens and/or host glycans. The collectin and galectin families are prominent examples of these two
Cristina Casals, Cristina Casals, María A. Campanero-Rhodes, María A. Campanero-Rhodes, Belén García-Fojeda, Belén García-Fojeda, Dolores Solís, Dolores Solís   +7 more
doaj   +1 more source

Role of collectin-11 in innate defence against uropathogenic infection

Innate Immunity, 2021
Classical collectins (surfactant protein A and D) play a significant role in innate immunity and host defence in uropathogenic Escherichia coli (UPEC)-induced urinary tract infection (UTI).
Hai Yuan, Zhao Gao, Xiaohan Lu, Fengqi Hu   +3 more
doaj   +1 more source

Detection of Cytokines and Collectins in Bronchoalveolar Fluid Samples of Patients Infected with Histoplasma capsulatum and Pneumocystis jirovecii

Journal of Fungi, 2021
Histoplasmosis and pneumocystosis co-infections have been reported mainly in immunocompromised humans and in wild animals. The immunological response to each fungal infection has been described primarily using animal models; however, the host response to
Laura E. Carreto-Binaghi, Eda P. Tenorio, Fernando R. Morales-Villarreal, El Moukhtar Aliouat, Edgar Zenteno, José-Arturo Martínez-Orozco, Maria-Lucia Taylor   +6 more
doaj   +1 more source

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

Viruses, 2018
Since the largest 2014–2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators.
Anne-Laure Favier, Olivier Reynard, Evelyne Gout, Martin van Eijk, Henk P. Haagsman, Erika Crouch, Viktor Volchkov, Christophe Peyrefitte, Nicole M. Thielens   +8 more
doaj   +1 more source

Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice

JCI Insight, 2021
Alpha-1 antitrypsin (AAT) is a major inhibitor of serine proteases in mammals. Therefore, its deficiency leads to protease–antiprotease imbalance and a risk for developing lung emphysema.
Lena Ostermann, Regina Maus, Jennifer Stolper, Lisanne Schütte, Konstantina Katsarou, Srinu Tumpara, Andreas Pich, Christian Mueller, Sabina Janciauskiene, Tobias Welte, Ulrich A. Maus   +10 more
doaj   +1 more source

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source

Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens

Frontiers in Physics, 2021
The complement system is assembled from a network of proteins that function to bring about the first line of defense of the body against invading pathogens.
Nehemiah T. Zewde, Rohaine V. Hsu, Dimitrios Morikis, Giulia Palermo, Giulia Palermo   +4 more
doaj   +1 more source

Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice

Respiratory Research, 2009
Background Glycosylation on the globular head of the hemagglutinin (HA) protein of influenza virus acts as an important target for recognition and destruction of virus by innate immune proteins of the collectin family.
Whitney Paul G, Tate Michelle D, Pickett Danielle L, Reading Patrick C, Job Emma R, Brooks Andrew G   +5 more
doaj   +1 more source

Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection [PDF]

, 2010
BACKGROUND: Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility.
Kazue Takahashi, Kevan L Hartshorn, Mitchell R White, Patience Moyo, Sheree McClear, Steffen Thiel, Wei-Chuan Chang   +6 more
core   +5 more sources

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. [PDF]

, 2015
Aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality.
Akaiwa, Ali, Azuma, Balloy, Bidula, Bidula, Bidula, D'Haese, De Pauw, DeHart, Foster, Garlatti, Hammond, Hearn, Hummelshøj, Kenawy, Latge, Le, Luo, Ma, Ma, Ma, Madan, Mambula, Martin, Martinez, Matsushita, Matsushita, Matsushita, Meier, Munthe-Fog, Neth, Romani, Rubino, Schelenz, Schelenz, Steele, Steinbach, Sturtevant, Taccone, Thornton, Torok, Werner, Wetering, Zacho, Zhang, Zhao   +46 more
core   +1 more source