Results 21 to 30 of about 5,247 (206)

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

Soluble Host Defense Lectins in Innate Immunity to Influenza Virus [PDF]

, 2012
Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of ...
Andrew G. Brooks, Michelle D. Tate, Patrick C. Reading, Wy Ching Ng   +3 more
core   +2 more sources

The carbohydrate recognition domain of collectins [PDF]

The FEBS Journal, 2011
Collectins are effector molecules of the innate immune system that play an important role in the first line of defence against bacteria, viruses and fungi. Most of their interactions with microorganisms are mediated through their carbohydrate recognition domain (CRD), which binds in a Ca2+‐dependent manner to glycoconjugates.
Veldhuizen, E.J.A., van Eijk, M., Haagsman, H.P.   +2 more
openaire   +4 more sources

Assessment of Surfactant Protein A (SP-A) dependent agglutination [PDF]

, 2010
Background: Monomers of the collectin surfactant associated protein-A (SP-A) are arranged in trimers and higher oligomers. The state of oligomerization differs between individuals and likely affects SP-A's functional properties.
Stefanie M Heinrich, Matthias Griese
core   +3 more sources

Surfactant protein-D and pulmonary host defense

Respiratory Research, 2000
Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial
Crouch Erika C
doaj   +1 more source

Isolation and expression of a novel MBL-like collectin cDNA enhanced by LPS injection in the body wall of the ascidian Ciona intestinalis [PDF]

, 2009
Collectins are a family of calcium-dependent lectins that are characterized by their collagen-like domains. Considerable interest has been focused on this class of proteins because of their ability to interact with components of the complement system ...
Bonura, A., Colombo, P., Longo, V., Parrinello, N., Salerno, G., Vizzini, A.   +5 more
core   +1 more source

Collectins, collectin receptors and the lectin pathway of complement activation

Clinical and Experimental Immunology, 1994
SummaryThe collectins are a group of soluble multimeric lectins, which contain collagenous segments, and resemble the complement protein Clq in aspects of their structures and functions. This group of proteins, which includes MBP, SP-A, SP-D, conglutinin and CL-43, are known to act as opsonins in various circumstances, and are likely to have roles in ...
R, Malhotra, J, Lu, U, Holmskov, R B, Sim   +3 more
openaire   +3 more sources

CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa

Frontiers in Immunology, 2018
Collectin liver 1 (CL-L1, alias collectin 10) and collectin kidney 1 (CL-K1, alias collectin 11) are oligomeric pattern recognition molecules associated with the complement system, and mutations in either of their genes may lead to deficiency and ...
Soren W. K. Hansen, Josephine B. Aagaard, Karen B. Bjerrum, Eva K. Hejbøl, Ole Nielsen, Henrik D. Schrøder, Karsten Skjoedt, Anna L. Sørensen, Jonas H. Graversen, Maiken L. Henriksen   +9 more
doaj   +1 more source

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

Frontiers in Immunology, 2020
Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the
Anna S. Świerzko, Maciej Cedzyński
doaj   +1 more source

Chimerolectins: Classification, structural architecture, and functional perspectives. [PDF]

Protein Sci
Abstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto-Junior VR, Cavada BS, Nascimento KS.   +2 more
europepmc   +2 more sources