Results 31 to 40 of about 9,867,423 (273)

Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases

Nutrients, 2018
In recent years evidence has emerged that neurodegenerative diseases (NDs) are strongly associated with the microbiome composition in the gut. Parkinson’s disease (PD) is the most intensively studied neurodegenerative disease in this context.
Sara Gerhardt, M. Mohajeri
semanticscholar   +1 more source

Maternal antibiotic-induced early changes in microbial colonization selectively modulate colonic permeability and inducible heat shock proteins, and digesta concentrations of alkaline phosphatase and TLR-stimulants in swine offspring. [PDF]

PLoS ONE, 2015
Elevated intake of high energy diets is a risk factor for the development of metabolic diseases and obesity. High fat diets cause alterations in colonic microbiota composition and increase gut permeability to bacterial lipopolysaccharide, and subsequent ...
Marie-Edith Arnal, Jing Zhang, Clett Erridge, Hauke Smidt, Jean-Paul Lallès   +4 more
doaj   +1 more source

Endoscopic Management of Benign Colonic Obstruction and Pseudo-Obstruction [PDF]

Clinical Endoscopy, 2020
There are a variety of causes of intestinal obstruction, with the most common cause being malignant diseases; however, volvulus, inflammatory bowel disease or diverticulitis, radiation injury, ischemia, and pseudo-obstruction can also cause colonic ...
Su Jin Jeong, Jongha Park
doaj   +1 more source

Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring

Pharmaceutics, 2021
The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition.
Glenn Lemmens, Arno Van Camp, Stephanie Kourula, Tim Vanuytsel, Patrick Augustijns   +4 more
doaj   +1 more source

Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation. [PDF]

PLoS ONE, 2016
BACKGROUND:CD5+ B cells are a type of regulatory immune cells, though the involvement of this B cell subset in intestinal inflammation and immune regulation is not fully understood.
Yoshiyuki Mishima, Shunji Ishihara, Akihiko Oka, Nobuhiko Fukuba, Naoki Oshima, Hiroki Sonoyama, Noritsugu Yamashita, Yasumasa Tada, Ryusaku Kusunoki, Ichiro Moriyama, Takafumi Yuki, Kousaku Kawashima, Yoshikazu Kinoshita   +12 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Progress in the treatment of colonic diverticular diseases [PDF]

Waike lilun yu shijian
The incidence of colonic diverticular disease is increasing significantly and is showing a trend of youthfulness. The treatment of colonic diverticulum disease mainly involves drugs, including antibiotics, rifaximin, and mesalazine.
KONG Lei, YANG Huali
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Role of Inflammation in Pathophysiology of Colonic Disease: An Update

International Journal of Molecular Sciences, 2020
Diseases of the colon are a big health burden in both men and women worldwide ranging from acute infection to cancer. Environmental and genetic factors influence disease onset and outcome in multiple colonic pathologies. The importance of inflammation in
N. Nasef, Sunali Y Mehta
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source