Results 181 to 190 of about 334,109 (235)

Arginase 2 Promotes Colorectal Cancer Metastasis via PI3K/AKT Pathway Activation and Regulates Tumor Immune Infiltration. [PDF]

Cancer Med
Zhang Y, Qu N, Mei J, Mo C, Wei L, Shen H, Zhou S, Hu J, Luo W, Mo X.   +9 more
europepmc   +1 more source

PFDN2 stabilizes PYCR2 to activate Wnt/β-catenin signaling and promote colorectal cancer progression. [PDF]

Sci Rep
Chang X, Chen P, Li L, Cao J, Hou S, Li H.   +5 more
europepmc   +1 more source

ALPP Induces Epithelial-Mesenchymal Transition by Activating the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells. [PDF]

Cancer Manag Res
Gao B, Li B, Hu J, Hu X, Su M.
europepmc   +1 more source

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Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116 cells

Biochemical and Biophysical Research Communications, 2020
JQ1 disrupts the binding of bromodomain and extra-terminal (BET) family of proteins to acetylated histones, modulates the expression of various genes, and inhibits the proliferation of cancer cells. We established two JQ1-resistant sublines from human colorectal cancer HCT116 cells. These resistant cells showed an 8- to 9-fold higher resistance to JQ1,
Chihiro Takahashi, Shingo Kondo, Kensuke Sadaoka, Shuhei Ishizuka, Kohji Noguchi, Yu Kato, Yoshikazu Sugimoto   +6 more
openaire   +3 more sources

Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116

Journal of Cellular Biochemistry, 2018
Abstract5‐fluorouracil (5‐FU) and oxaliplatin (OxaPt) are the main chemotherapeutics for colorectal cancer (CRC). Chemotherapy response rates for advanced CRC remain low, primarily due to intrinsic or acquired chemoresistance. The importance of Notch and Wnt signaling for carcinogenesis of CRC as well as crosstalk of Notch and Wnt signaling with many ...
Egle Kukcinaviciute, Violeta Jonusiene, Ausra Sasnauskiene, Daiva Dabkeviciene, Eigile Eidenaite, Arvydas Laurinavicius   +5 more
openaire   +3 more sources

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Organic & Biomolecular Chemistry, 2015
We synthesized a series of pyrimidinedione derivatives and evaluated their activities.
Yi-Min, Liu, Hsueh-Yun, Lee, Mei-Jung, Lai, Shiow-Lin, Pan, Hsiang-Ling, Huang, Fei-Chiao, Kuo, Mei-Chuan, Chen, Jing-Ping, Liou   +7 more
openaire   +3 more sources

DIFFERENTIAL GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY GOSSYPOL BETWEEN HCT116 AND HCT116/BAX^−/– COLORECTAL CANCER CELLS

Clinical and Experimental Pharmacology and Physiology, 2007
SUMMARY Bax is a very important pro‐apoptosis molecule. HCT116/Bax−/– cells do not express the pro‐apoptosis Bcl‐2 family member, Bax. In the present study, the anticancer effects of gossypol on HCT116 and HCT116/Bax−/– cells were compared in terms of inhibition of cell growth, inhibition of colony formation and induction of apoptosis.
Manchao, Zhang, Hongpeng, Liu, Zhenkun, Tian, Jenny, Huang, Mylene, Remo, Q Quentin, Li   +5 more
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Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Statins, the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors with cholesterol-lowering properties, were recently shown to exhibit anti-cancer effects. However, the molecular mechanism underlying statin-induced cancer cell death remains to be elucidated.
Hang-Lung, Chang, Chih-Yu, Chen, Ya-Fen, Hsu, Wen-Shin, Kuo, George, Ou, Pei-Ting, Chiu, Yu-Han, Huang, Ming-Jen, Hsu   +7 more
openaire   +2 more sources