Results 211 to 220 of about 4,253,992 (294)

Single-cell multi-omics analysis of the tumour microenvironment for colorectal cancer liver metastasis. [PDF]

Clin Transl Med
Guan J, Guo M, Hu M, Wu S, Qiu J, Ma X, Guo Y, Chen H, Zhou Z.   +8 more
europepmc   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Prediction of colorectal cancer liver metastasis through an MRI radiomic model. [PDF]

Sci Rep
Wu YK, Wang X, Du PZ, Zhang P, Liu N, Tao YY, Zheng J, Huang XH, Yang L.   +8 more
europepmc   +1 more source

Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm

Gut Medicine, EarlyView.
ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang, Narisu Hu, Shuang Pan, Sohaib Shujaat, Zhihui Tang, Hongyang Ma   +5 more
wiley   +1 more source

Pretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV‐Negative Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Introduction Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV‐negative HNSCC.
Gianluca Savoia, Michael P. Hier, Nader Sadeghi, Alex Mlynarek, Keith Richardson, Sabrina Daniela Silva Wurzba, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Marco A. Mascarella   +11 more
wiley   +1 more source

Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis. [PDF]

NPJ Digit Med
Huang R, Liu Q, Jin X, Bai X, Wu Y, He X, Wang Y, Jiang Z, Zhang Y, Shi Y, Wang L, Zhu W.   +11 more
europepmc   +1 more source

LRP2-mediated regulation of ferroptosis through the Wnt/β-catenin-GPX4 axis in colorectal cancer liver metastasis and chemoresistance. [PDF]

Cell Death Discov
Zhao S, Sun L, Xia J, Yan S, Zhang B, Lu B, Huang N, Sun F, Shen F.   +8 more
europepmc   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

International Journal of Cancer, EarlyView.
ABSTRACT Spot‐based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single‐cell RNA sequencing (scRNA‐seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular heterogeneity within spots, requiring computational deconvolution to ...
Stefan Altendorfer, Scott J. Walker, Carsten O. Daub   +2 more
wiley   +1 more source