Results 211 to 220 of about 141,334 (303)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRAS^G12C mutation colorectal cancer liver metastasis. [PDF]

J Exp Clin Cancer Res
Li W, Yuan W, Du Z, Wang X, Wang D, Xing S, Shen T, Lu C, Chen J, Yu A, Jiang X, Zhang S, Zheng S, Feng X, Wang T, Zuo J, Chen J, Zhang C, Wang X, Zhang C.   +19 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Integrated single-cell and spatial transcriptomics uncover SPP1⁺ and HLA-DRB5⁺ macrophages as key modulators of the immune microenvironment in colorectal cancer liver metastasis. [PDF]

J Transl Med
Xie S, Li J, Heng S, Xiao J, Chen J, Qi X.   +5 more
europepmc   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis. [PDF]

Cell Rep Med
Zhang Y, Zhang Y, Shen C, Li J, Wang H, Hamad A, Cao C, El Moheb M, Wang Y, Xia Y, Cummins KC, Beane J, Ejaz A, Huang H, Tsung A, Zhang H.   +15 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Construction of a prognostic model for colorectal cancer liver metastasis: A retrospective study based on population data. [PDF]

World J Gastrointest Oncol
Xie MJ, Li JJ, Guo YJ, Wang Q, Tan ZB, Li YL, Li JP.   +6 more
europepmc   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion. [PDF]

Mol Cancer
Trebo M, Maurer T, Krendl FJ, Salcher S, Martowicz A, Hautz T, Sopper S, Amann A, Cardini B, Poelsler LH, Mair A, Hofmann J, Meszaros AT, Hermann M, Günther M, Ormanns S, Trajanoski Z, Schneeberger S, Wolf D, Oberhuber R, Pircher A.   +20 more
europepmc   +1 more source