Results 201 to 210 of about 141,334 (303)

Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study

American Journal of Hematology, EarlyView.
ABSTRACT Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...
Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li   +11 more
wiley   +1 more source

Inosine alleviates colorectal cancer liver metastasis by promoting M1 macrophage polarization and modulating the PI3K/AKT signaling pathway. [PDF]

Front Immunol
Dong Y, Ma Y, Yu Q, Shi Z, Wang C, Che Y, Liu H, Wan D, Shao W, Xiao H.   +9 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Agonist signaling drives neutrophil subpopulations to promote/inhibit colorectal cancer liver metastasis. [PDF]

Nat Commun
Xu Z, Feng H, Feng W, Zhang Y, Huo J, Xu Z, Chen F, Gao H, Lv Z, Liu W, Tuersun A, Yu S, Li W, Zong Y, Shen X, Cheng X, Zhao J, Lu A.   +17 more
europepmc   +1 more source

A microscopically assisted limited colectomy mouse model of early colon cancer

Animal Models and Experimental Medicine, EarlyView.
Establishment, surgery, and evaluation process of a microscope‐assisted limited colon resection mouse model for early‐stage colon cancer. Abstract Background Currently, there is a lack of an adequate rodent model for investigating surgical techniques and comprehensive treatment options for patients with colorectal cancer (CRC).
Yu Han, Yixin Zhang, Dazhi Gao, Xuefeng Zhao   +3 more
wiley   +1 more source

Metabolic syndrome in colorectal cancer liver metastasis: metabolic reprogramming and microenvironment crosstalk. [PDF]

Front Immunol
Ma Z, Wang S, Liu S, Yang W, Hu J, Lv L, Yu Q, Lu Y.   +7 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Neutrophil extracellular traps regulate LDHA expression to promote colorectal cancer liver metastasis. [PDF]

J Transl Med
Li N, Yang S, Hu C, Zheng J, Yang H, Jiang T, Li X, Han Q, Zhang X, Yang Y, Khan S, Sun B.   +11 more
europepmc   +1 more source

SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts. [PDF]

Cancer Res
Liu S, Zhang Z, Wang Z, Liu C, Liang G, Xu T, Li Z, Duan X, Xu G, Feng X, Feng Q, Wang Q, Han D, Zhang C, Li J, Shen L.   +15 more
europepmc   +1 more source

Single-cell transcriptomic profiling reveals liver fibrosis in colorectal cancer liver metastasis. [PDF]

Exp Mol Med
Deng Y, Guo C, Liu X, Li X, Liu J, Liu W, Chen J, Huang Z, Zhang Y, Bi X, Zhao J, Zhou J, Li Z, Wu H, Xing B, Chen Q, Zhao H.   +16 more
europepmc   +1 more source