Pharmacological and Pharmacokinetic Insights Into Columbianadin: A Promising Natural Anti‐Inflammatory Compound [PDF]
Mediators of InflammationColumbianadin (CBN), a dihydroangelic acid ester and a naturally occurring coumarin compound, is primarily derived from plants in the Apiaceae family, notably the traditional Chinese medicinal herb Angelica pubescens.
Le Tang
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Inhibitory Effects of Columbianadin on Nociceptive Behaviors in a Neuropathic Pain Model, and on Voltage-Gated Calcium Currents in Dorsal Root Ganglion Neurons in Mice [PDF]
Frontiers in Pharmacology, 2020 Radix angelicae pubescentis (RAP) has been used in Chinese traditional medicine to treat painful diseases such as rheumatism and headache. A previous study has reported that columbianadin (CBN), a major coumarin in RAP inhibits acute and inflammatory ...
Yong-Hua Ji +2 more
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Anti-Inflammatory Effect of Columbianadin against D-Galactose-Induced Liver Injury In Vivo via the JAK2/STAT3 and JAK2/p38/NF-κB Pathways [PDF]
PharmaceuticalsAngelicae pubescentis radix (APR) has been traditionally used for thousands of years in China to treat rheumatoid arthritis (RA), an autoimmune disorder.
Lin Peng
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Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway [PDF]
Acta Cirúrgica Brasileira, 2023 Purpose: Oxidative stress and apoptosis contribute to the pathological basis of doxorubicin (DOX)-induced cardiotoxicity. Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens.
Bo Peng +6 more
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Graphene Assisted in the Analysis of Coumarins in Angelicae Pubescentis Radix by Dispersive Liquid–Liquid Microextraction Combined with 1H-qNMR [PDF]
Molecules, 2021 The content of active components in traditional Chinese medicine is relatively small, and it is difficult to detect some trace components with modern analytical instruments, so good pretreatment and extraction are very important in the experiment ...
Yanmei Feng +3 more
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Determination of Five Coumarins in Angelicae Pubescentis Radix from Different Origins by HPTLC-Scanning [PDF]
Journal of Analytical Methods in Chemistry, 2022 The HPTLC method is widely used in the field of quality evaluation and component analysis of traditional Chinese medicine (TCM). This work developed an HPTLC method to determine the five effective components of osthole, columbianadin, isoimperatorin ...
Dangtong Ji +5 more
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Pharmacological Research Modern Chinese Medicine, 2023 Introduction: Herbal medicines have been used for the treatment of human disorders and associated secondary complications since a very early age. Herbal medicines are composed with a variety of medicinal plants and their derived products.
Dinesh Kumar Patel
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Columbianadin ameliorates experimental acute reflux esophagitis in rats via suppression of NF-κB pathway [PDF]
Acta Cirúrgica BrasileiraPurpose: Reflux esophagitis is a condition characterized by inflammation and irritation of the esophagus, resulting from the backflow of stomach acid and other gastric contents into the esophagus. Columbianadin is a coumarin derivative that exhibits anti-
Ying Wu +2 more
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Columbianadin Dampens In Vitro Inflammatory Actions and Inhibits Liver Injury via Inhibition of NF-κB/MAPKs: Impacts on ∙OH Radicals and HO-1 Expression [PDF]
Antioxidants, 2021 Columbianadin (CBN), a natural coumarin isolated from Angelica decursiva, is reported to have numerous biological activities, including anticancer and platelet aggregation inhibiting properties.
Thanasekaran Jayakumar +10 more
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TeroACT: A terpenoid bioactivity landscape and discovery platform [PDF]
Acta Pharmaceutica Sinica BTerpenoids exhibit diverse biological activities and thus have a wide range of pharmacological applications. In modern drug discovery, data-driven deep models play a crucial role in facilitating efficient feature representation and knowledge inference ...
XiaoJuan Shen +7 more
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