LC–MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin [PDF]
Chemistry Central Journal, 2014 Columbianadin, one of the active coumarins, is isolated from Radix Angelicae pubescentis which has been used as a traditional Chinese medicine for the treatment of rheumatic diseases for thousands of years. A fast and sensitive method is required for the determination of columbianadin for pharmacokinetic studies.
Chang, Yan-xu +9 more
openaire +4 more sources
Vibrational spectroscopic studies on the natural product, columbianadin [PDF]
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2003 NIR-FT Raman and FT-IR spectra of columbianadin, extracted from seeds and roots of Heracleum candolleaum, were recorded and analyzed. The vibrational frequencies of the compound have been computed using semi-empirical AM1 method and compared with experimental values.
Nielsen, Ole Faurskov +4 more
openaire +3 more sources
Constructing a Core Collection of the Medicinal Plant Angelica biserrata Using Genetic and Metabolic Data [PDF]
Frontiers in Plant Science, 2020 Angelica biserrata is an important medicinal plant in Chinese traditional medicine. Its roots, which are known as Duhuo in Chinese, are broadly applied to treat inflammation, arthritis, and headache. With increasing market demand, the wild resources of A.
Man Liu +6 more
doaj +2 more sources
Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability [PDF]
Molecules, 2015 Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR ...
Yan-Fang Yang +4 more
doaj +2 more sources
Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis [PDF]
Molecules, 2018 Angelicae Pubescentis Radix (APR) is a widely-used traditional Chinese medicine. Pharmacological studies have begun to probe its biological activities on neurological disorders recently.
Yan-Fang Yang, Lei Zhang, Xiu-Wei Yang
doaj +2 more sources
Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS. [PDF]
Evid Based Complement Alternat Med, 2022 An ultraperformance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method was established to simultaneously determine 14 compounds of Angelicae pubescentis Radix (APR) in normal and arthritis rat plasma in which chloramphenicol and daidzein were used as the internal standards.
Hou A +8 more
europepmc +2 more sources
Illumination on Chemical Compounds from Qufeng Zhitong Capsule and Its Potential Pharmacological Mechanism against Rheumatoid Arthritis Based on UHPLC/Q-Orbitrap-MS Combined with Network Pharmacology Analysis. [PDF]
Int J Anal Chem, 2022 Qufeng Zhitong capsule (QZC), a Chinese patent medicine officially approved in China for the treatment of rheumatoid arthritis (RA) and other diseases, possesses the primary effects of dispelling wind, relieving pain, and promoting blood circulation, whose clinical applications have been confined owing to the incomplete elucidation of its chemical ...
Xue M +6 more
europepmc +2 more sources
Multi-target direct-acting SARS-CoV-2 antivirals against the nucleotide-binding pockets of virus-specific proteins. [PDF]
Virology, 2022 The nucleotide-binding pockets (NBPs) in virus-specific proteins have proven to be the most successful antiviral targets for several viral diseases. Functionally important NBPs are found in various structural and non-structural proteins of SARS-CoV-2. In
Rani R +7 more
europepmc +2 more sources
Construction of a nanozyme composite drug delivery system based on columbianadin for inflammatory bowel disease therapy. [PDF]
RSC AdvAn oral nanozyme-based composite hydrogel (MXene/CBN@GelMA) is developed for targeted inflammatory bowel disease therapy.
Zhang Y +7 more
europepmc +3 more sources
Journal of Medical Virology, Volume 95, Issue 3, March 2023., 2023 Abstract Hepatitis B surface antigen (HBsAg) loss and seroconversion, which is considered as functional cure of chronic Hepatitis B virus (HBV) infection, is rarely achieved even after long‐term antiviral treatments. Therefore, new antiviral strategies interfering with other HBV replication steps are required, especially those that could efficiently ...
Fang Ren +17 more
wiley +1 more source