TeroACT: A terpenoid bioactivity landscape and discovery platform [PDF]
Acta Pharmaceutica Sinica BTerpenoids exhibit diverse biological activities and thus have a wide range of pharmacological applications. In modern drug discovery, data-driven deep models play a crucial role in facilitating efficient feature representation and knowledge inference ...
XiaoJuan Shen +7 more
doaj +2 more sources
The Use of 1H-qNMR Method for Simultaneous Determination of Osthol, Columbianadin, and Isoimperatorin in Angelicae Pubescentis Radix [PDF]
Journal of AOAC INTERNATIONAL, 2020 Objective The goal of this work was to establish a method to identify and quantify the main active components in Angelicae Pubescentis Radix (APR) quickly, simply, and accurately.
Daiyu Qiu +4 more
core +4 more sources
LC–MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin [PDF]
Chemistry Central Journal, 2014 Columbianadin, one of the active coumarins, is isolated from Radix Angelicae pubescentis which has been used as a traditional Chinese medicine for the treatment of rheumatic diseases for thousands of years. A fast and sensitive method is required for the determination of columbianadin for pharmacokinetic studies.
Bing Lu +25 more
core +3 more sources
Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models. [PDF]
Front PharmacolIntroductionPain is a complex phenomenon involving physiological and psychological responses to noxious stimuli. Long-term opioid or NSAID use leads to reduced efficacy and tolerance. Initially a thermosensitive receptor, TRPV1 is increasingly recognized
Chen H +6 more
europepmc +3 more sources
Investigation of c-Fos/c-Jun Signaling Pathways in Periostracum Cicadae’s Inhibition of EMT in Gastric Tissue [PDF]
PharmaceuticalsBackground/Objectives: Periostracum Cicadae (PC) is commonly used to treat chronic atrophic gastritis (CAG), but its underlying mechanisms are unclear.
Hua Liang +5 more
doaj +2 more sources
A Diol-Based-Matrix Solid-Phase Dispersion Method for the Simultaneous Extraction and Determination of 13 Compounds From Angelicae Pubescentis Radix by Ultra High-Performance Liquid Chromatography. [PDF]
Front Pharmacol, 2019 A simple and eco-friendly Diol-based-matrix solid-phase dispersion method (MSPD) was optimized and established to simultaneously extract 13 bioactive compounds (7 coumarins and 6 phenolic acids) in Angelicae Pubescentis Radix (APR) by ultrahigh ...
Ding M +6 more
europepmc +3 more sources
The Tissue Distribution of Four Major Coumarins after Oral Administration of Angelicae Pubescentis Radix Extract to Rats Using Ultra-High-Performance Liquid Chromatography. [PDF]
Evid Based Complement Alternat Med, 2019 Angelicae pubescentis radix (APR) is widely applied in treating rheumatoid arthritis in China. Coumarins are the major active compounds of APR extract including columbianetin, columbianetin acetate, osthole, and columbianadin. The in vivo behavior of the four major coumarins of APR has not been systematically reported.
Ge Y +10 more
europepmc +2 more sources
Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey. [PDF]
Front PharmacolIntroductionHeracleum L. has been known as “hogweed” and used for inflammatory diseases, including fever, enteritis, and bronchitis, for many years worldwide. The Heracleum genus is also prominently recognized for its high content of coumarins, which are
Kurtul E +5 more
europepmc +3 more sources
Journal of Medical Virology, Volume 95, Issue 3, March 2023., 2023 Abstract Hepatitis B surface antigen (HBsAg) loss and seroconversion, which is considered as functional cure of chronic Hepatitis B virus (HBV) infection, is rarely achieved even after long‐term antiviral treatments. Therefore, new antiviral strategies interfering with other HBV replication steps are required, especially those that could efficiently ...
Fang Ren +17 more
wiley +1 more source
Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential [PDF]
, 2021 In recent years, natural compounds have emerged as inducers of non-canonical cell death. The isothiocyanate sulforaphane (SFN) is a well-known natural anticancer compound with remarkable pro-apoptotic activity.
Catanzaro, Elena +7 more
core +1 more source