Results 11 to 20 of about 303 (129)

Pharmacological and Pharmacokinetic Insights Into Columbianadin: A Promising Natural Anti-Inflammatory Compound [PDF]

Mediators of Inflammation
Columbianadin (CBN), a dihydroangelic acid ester and a naturally occurring coumarin compound, is primarily derived from plants in the Apiaceae family, notably the traditional Chinese medicinal herb Angelica pubescens.
Yusong Wang, Le Tang, Jia Miao, Shouxiang Cheng, Yanqing Xu, Wen Xie   +5 more
doaj   +5 more sources

Columbianadin ameliorates experimental acute reflux esophagitis in rats via suppression of NF-κB pathway [PDF]

Acta Cirúrgica Brasileira
Purpose: Reflux esophagitis is a condition characterized by inflammation and irritation of the esophagus, resulting from the backflow of stomach acid and other gastric contents into the esophagus. Columbianadin is a coumarin derivative that exhibits anti-
Ying Wu, Shaik Althaf Hussain, Minghai Luo   +2 more
doaj   +4 more sources

Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions [PDF]

JOR Spine
Background The molecular of intervertebral disc degeneration (IVDD) is still unclear. When it comes to treating decoction, traditional Chinese medicine is effective.
Chao Song, Xiaofei Wu, Chaoqi Chen, Baoxin Shen, Yongliang Mei, Qian Yan, Feng Jiang, Feng Chen, Fei Liu   +8 more
doaj   +3 more sources

Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MS/MS: Application to Pharmacokinetics of Columbianadin after Oral Administration. [PDF]

Evid Based Complement Alternat Med, 2018
Columbianadin and its metabolite columbianetin exhibited the anti‐inflammatory, analgesic, calcium channel blocking and antitumor activities. To compare the differences between pharmacokinetics of columbianadin and its metabolite columbianetin after oral administration of pure columbianadin and Angelicae Pubescentis Radix (APR) extract, a simple and ...
Li J, Li Z, Luo Q, Wang CP, He J, Pang X, Teye Azietaku J, Chang YX.   +7 more
europepmc   +5 more sources

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals [PDF]

Journal of Biomedical Science, 2020
Background Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic activity.
Shaw-Min Hou, Chih-Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Marappan Velusamy, Joen-Rong Sheu   +6 more
doaj   +5 more sources

Comparison of Pharmacokinetic Profiles of 14 Major Bioactive Components in Normal and Arthritic Model Rats after Oral Administration of Angelicae pubescentis Radix by UPLC-MS/MS. [PDF]

Evid Based Complement Alternat Med, 2022
An ultraperformance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method was established to simultaneously determine 14 compounds of Angelicae pubescentis Radix (APR) in normal and arthritis rat plasma in which chloramphenicol and daidzein were used as the internal standards.
Hou A, Yu H, Wang S, Zhang J, Wang X, Zheng S, Yang L, Kuang H, Jiang H.   +8 more
europepmc   +2 more sources

Illumination on Chemical Compounds from Qufeng Zhitong Capsule and Its Potential Pharmacological Mechanism against Rheumatoid Arthritis Based on UHPLC/Q-Orbitrap-MS Combined with Network Pharmacology Analysis. [PDF]

Int J Anal Chem, 2022
Qufeng Zhitong capsule (QZC), a Chinese patent medicine officially approved in China for the treatment of rheumatoid arthritis (RA) and other diseases, possesses the primary effects of dispelling wind, relieving pain, and promoting blood circulation, whose clinical applications have been confined owing to the incomplete elucidation of its chemical ...
Xue M, Zhang L, Zhao Y, Mu Q, Cui Y, Qian K, Chai X.   +6 more
europepmc   +2 more sources

Effectiveness of Columbianadin, a Bioactive Coumarin Derivative, in Perturbing Transient and Persistent I_Na. [PDF]

Int J Mol Sci, 2021
Columbianadin (CBN) is a bioactive coumarin-type compound with various biological activities. However, the action of CBN on the ionic mechanism remains largely uncertain, albeit it was reported to inhibit voltage-gated Ca2+ current or to modulate TRP-channel activity.
Chang WT, Wu SN.
europepmc   +4 more sources

Columbianadin Suppresses Lipopolysaccharide (LPS)-Induced Inflammation and Apoptosis through the NOD1 Pathway [PDF]

Molecules, 2019
Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens. Although the anti-inflammatory activity of CBN has been reported, the underpinning mechanism of this remains unclear.
Chao Zhang, Alan Chen-Yu Hsu, He Pan, Yinuo Gu, Xu Zuo, Bing Dong, Ziyan Wang, Jingtong Zheng, Junying Lu, Ruipeng Zheng, Fang Wang   +10 more
doaj   +3 more sources

Potential Therapeutic Mechanism of Radix Angelicae Biseratae and Dipsaci Radix Herb Pair against Osteoarthritis: Based on Network Pharmacology and Molecular Docking. [PDF]

Evid Based Complement Alternat Med, 2023
Background. A major contributor to older disability is osteoarthritis. Radix Angelicae Biseratae (known as Duhuo in China, DH, the dried rhizome of Angelica pubescens) and Dipsaci Radix (known as Xuduan in China, XD, the dried rhizome of Dipsacus asper Wall) herb pair (DXHP) is widely used to treat osteoarthritis, but the underlying molecular ...
Xi Y, Zhao T, Shi M, Zhang X, Bao Y, Gao J, Shen J, Wang H, Xie Z, Wang Q, Li Z, Qin D.   +11 more
europepmc   +2 more sources