Results 51 to 60 of about 1,144,978 (368)

Diversity and bioactivity of culturable bacteria from Acanthus ebracteatus

open access: yesGuangxi Zhiwu, 2023
Acanthus ebracteatus is a special kind of rare mangrove plant, possessing great medicinal value. In this paper, in order to study the diversity of endophytic and rhizosphere culturable bacteria in the A.
Zhe LI   +6 more
doaj   +1 more source

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

open access: yeseLife, 2021
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases.
Erich Stefan   +7 more
doaj   +1 more source

Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer.

open access: yesChemical Society Reviews, 2021
Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that has now accumulated more than 30 years of experience. In the ongoing MHT clinical trials for the treatment of brain and prostate tumors, iron oxide nanoparticles
H. Gavilán   +7 more
semanticscholar   +1 more source

Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries. [PDF]

open access: yes, 2008
Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has
Greaves, John   +3 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

High-throughput in-situ characterization and modelling of precipitation kinetics in compositionally graded alloys

open access: yes, 2015
The development of new engineering alloy chemistries is a time consuming and iterative process. A necessary step is characterization of the nano/microstructure to provide a link between the processing and properties of each alloy chemistry considered ...
De Geuser, F.   +3 more
core   +3 more sources

Similarity-based virtual screening using 2D fingerprints [PDF]

open access: yes, 2006
This paper summarises recent work at the University of Sheffield on virtual screening methods that use 2D fingerprint measures of structural similarity. A detailed comparison of a large number of similarity coefficients demonstrates that the well-known ...
Willett, P.
core   +1 more source

The synthesis of a small library of prospective growth hormone secretagogues [PDF]

open access: yesJournal of the Serbian Chemical Society, 1999
Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
Pejović Vojislav   +2 more
doaj   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Towards the Development of Sequence-Selective Artificial Proteases

open access: yesCHIMIA, 1999
The development of artificial sequence-selective proteolytic metal complexes is endeavoured by use of encoded combinatorial chemistry.
Helma Wennemers
doaj   +1 more source

Home - About - Disclaimer - Privacy