Results 111 to 120 of about 1,931,388 (325)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

DNA damage in breast epithelial cells: detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts [PDF]

, 1997
Francis L. Martin, Stanley Venitt, Paul L. Carmichael, C. Crofton-Sleigh, Edwin M. Stone, K J Cole, B.A. Gusterson, P.L. Grover, David H. Phillips   +8 more
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Comet assay studies indicate that caffeine-mediated increase in radiation risk of embryos is due to inhibition of DNA repair [PDF]

, 1996
W.‐U. Müller, Thomas Bauch, Andrzej Wójcik, W. Böcker, C. Streffer   +4 more
openalex   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Modification of the Comet assay for the detection of DNA strand breaks in extremely small tissue samples [PDF]

, 1999
Robert S. Tebbs
openalex   +1 more source

Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine

Journal of Radiation Research, 2016
The biological effect of ionizing radiation (IR) on genomic DNA is thought to be either direct or indirect; the latter is mediated by IR induction of free radicals and reactive oxygen species (ROS).
T. Kurashige, M. Shimamura, Y. Nagayama
semanticscholar   +1 more source

Ce‐LLMs: Status and trends of education‐specific large language models developed in China

Future in Educational Research, EarlyView.
Abstract The prevalence of AI hallucination in general‐purpose large language models (LLMs) poses significant pedagogical challenges, particularly in terms of content credibility and reliability. In response, China has launched the development of education‐specific LLMs as a national strategic initiative. However, current reports on Chinese educational
Tao Xie, Yingli Zhou, Jiazhen Yu
wiley   +1 more source

Fragility Index analysis for robustness of evidence in Randomized Controlled Trials in National Comprehensive Cancer Network (NCCN) guidelines for rectal cancer

International Journal of Cancer, EarlyView.
What's New? Data from randomized controlled trials (RCTs) forms a foundation for rectal cancer treatment guidelines. The reliability of such data is therefore essential for evidence‐based clinical decision‐making. This study assessed the robustness of RCTs cited in the latest National Comprehensive Cancer Network (NCCN) guidelines for rectal cancer ...
Nir Horesh, Justin Dourado, Peter Rogers, Pauline Aeschbacher, Zoe Garoufalia, Rachel Gefen, Ebram Salama, Sameh Hany Emile, Steven D. Wexner   +8 more
wiley   +1 more source

Laser scanning cytometry for comet assay analysis [PDF]

, 2000
Anita Petersen, Robert Gniadecki, Hans Christian Wulf   +2 more
openalex   +1 more source