Results 111 to 120 of about 57,805 (348)

A Study of Cytogenetic Stability of Induced Pluripotent Stem Cells Using Karyotyping and Comet Assay Techniques [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Induced pluripotent stem cells (iPSCs) have the capability to undergo unlimited selfrenewal and differentiation into all cell types in the body.
Payam Ghasemi-Dehkordi, Mehdi Allahbakhshian-Farsani, Narges Abdian, Hamideh Jafari-Ghahfarokhi, Javad Saffari-Chaleshtori, Marzieh Sadeghiani, Amin Mirzaeian, Morteza Hashemzadeh-Chaleshtori   +7 more
doaj  

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]

, 2019
During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe, Cooper, Coutts, Coutts, Coyle, Dayel, Demonacos, Firat-Karalar, Graef, Hu, Jahreiss, Kaiser, Kast, Klionsky, Koronakis, Li, Mathiowetz, Mi, Okrut, Padrick, Padrick, Palmgren, Pankiv, Pankiv, Papinski, Quinlan, Quinlan, R. Dyche Mullins, Ran, Rohatgi, Rohatgi, Schlüter, Shibutani, Shikama, Sun, Urbanek, Welch, Xiaohua Hu, Yamamoto, Zhao, Zuchero   +40 more
core   +2 more sources

Heart failure outcomes and empagliflozin effects in patients with heart failure and reduced ejection fraction in sinus rhythm or atrial fibrillation: Data from EMPEROR‐Reduced

European Journal of Heart Failure, EarlyView.
Empagliflozin effects and heart failure outcomes in patients with heart failure with reduced ejection fraction and atrial fibrillation or sinus rhythm. AF, atrial fibrillation; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HHF, hospitalization for heart failure; KCCQ, Kansas City Cardiomyopathy Questionnaire; SE, standard error ...
Michael Böhm, Javed Butler, Amr Abdin, Gerasimos Filippatos, João Pedro Ferreira, Stuart J. Pocock, Martina Brueckmann, Anne Pernille Ofstad, Elke Schueler, Christoph Wanner, Faiez Zannad, Stefan D. Anker, Milton Packer, on behalf of the EMPEROR‐Reduced Trial Committees and Investigators   +13 more
wiley   +1 more source

Genomic instability in patients with type 2 diabetes mellitus on hemodialysis

Revista Brasileira de Hematologia e Hemoterapia, 2012
OBJECTIVE: A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay.
Roberta Passos Palazzo, Pamela Brambilla Bagatini, Patrícia Brandt Schefer, Fabiana Michelsen de Andrade, Sharbel Weidner Maluf   +4 more
doaj   +1 more source

The radioprotective effect of resveratrol against genotoxicity induced by γ-irradiation in mice blood lymphocytes [PDF]

, 2017
In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals.
Hejazi, Seyed Hossein., Koohian, Farideh., Moradi, Mohammad-Taghi., Shahbazi-Gahrouei, Daryoush., Shanei, Ahmad.   +4 more
core   +1 more source

Adherence to guideline‐directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

European Journal of Heart Failure, EarlyView.
Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline‐directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non‐adherence represents a critical barrier limiting real‐world efficacy of GDMT.
Gianluigi Savarese, Felix Lindberg, Antonio Cannata, Marianna Adamo, Giuseppe Ambrosio, Pietro Ameri, Markus S. Anker, Magnus Bäck, Antoni Bayes‐Genis, Tuvia Ben Gal, Frieder Braunschweig, Ovidiu Chioncel, Emilia D'Elia, Hassan El‐Tamimi, Gerasimos Filippatos, Nicolas Girerd, Loreena Hill, Ewa Jankowska, Kamlesh Khunti, Basil S. Lewis, Brenda Moura, Offer Amir, Stefania Paolillo, Massimo Piepoli, Abdulla Shehab, Maggie Simpson, Hadi Skouri, Davide Stolfo, Carlo Gabriele Tocchetti, Cristiana Vitale, Maurizio Volterrani, Stephan von Haehling, Sven Wassmann, Mehmet Birhan Yilmaz, Juan Carlos Kaski, Dobromir Dobrev, Marco Metra, Giuseppe M.C. Rosano   +37 more
wiley   +1 more source

Outcomes of periodontal therapy: Strengthening the relevance of research to patients. A co‐created review

Periodontology 2000, EarlyView., 2023
Abstract Periodontitis is a long‐term condition affecting up to half of the population globally and causing significant impacts on life quality. Successful management depends on taking life‐long ownership of the condition by those affected. There is a wealth of research to inform on management options. However, most of the research has been designed by
Ian Needleman, Neil Almond, Natalie Leow, Jim Phillips   +3 more
wiley   +1 more source

DNA damage in buccal cells in oral PMDs and malignant disorders by comet assay

Brazilian Journal of Oral Sciences, 2019
Aim: DNA damage associated with Oral Squamous Cell Carcinoma (OSCC) and potentially malignant disorders (PMDs) is produced due to carcinogenic agents or increased oxidative stress. Comet assay can assist in early detection and evaluation of the amount of
Garima Rawat, Aadithya B Urs, Anita Chakravarti, Priya Kumar   +3 more
doaj   +1 more source