Results 111 to 120 of about 2,938,052 (285)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Sociologies, 2017 In Argentine, there is renewed attention to civil society organizations both as a social policy device to solve unemployment and as a form of political commitment.
Pia V. Rius
doaj
Social SciencesThe research focuses on the impact of transformational leadership on the decision to stay mediated by commitment after a court refusal regarding illegal extraordinary congress involving the outsiders of a political party in Indonesia (in this case, it is
Herzaky Mahendra Putra +5 more
doaj +1 more source
A Practitioner’s Approach to Drucker’s Knowledge - Worker Productivity in the 21st Century: A New Model (Part One) [PDF]
Revista de Management Comparat International, 2010 This article examines productivity in the context of the 21st century, focusing on Drucker’s prophecy of knowledge-worker productivity, the power of ‘unified strategy’, organisational interdependence and a practitioner’s approach to knowledge-worker ...
Peter S. WONG , Philip A. NECK
doaj
Leadership Styles and Effectiveness Among Sub-Saharan African Employees [PDF]
, 2018 This study sought to determine whether a significant relationship exists between dimensions of transactional and transformational leadership styles and leadership effectiveness within sub-Saharan Africa.
Fadare, Samuel
core +1 more source
Experimental unconditionally secure bit commitment
, 2013 Bit commitment is a fundamental cryptographic task that guarantees a secure commitment between two mutually mistrustful parties and is a building block for many cryptographic primitives, including coin tossing, zero-knowledge proofs, oblivious transfer ...
Adán Cabello +16 more
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Measures of New Constructs or Old Ones? The Case of Organizational Commitment and Job Satisfaction [PDF]
, 1991 The construct validity of organizational commitment has recently been investigated in several studies. The authors of these studies have concluded that organizational commitment is a valid construct, sufficiently distinct from job satisfaction.
Gerhart, Barry A., Judge, Timothy A.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
(WP 2010-07) Examining Megachurch Growth: Free Riding, Fit, and Faith [PDF]
, 2010 Megachurches are thriving in religious markets at a time when Americans are asserting their ability as consumers of religious products to engage in religious switching.
Daniels, Joseph P., von der Ruhr, Marc
core +1 more source