Results 51 to 60 of about 992,860 (360)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Sports Medicine, 2016 BackgroundGross motor competence confers health benefits, but levels in children and adolescents are low. While interventions can improve gross motor competence, it remains unclear which correlates should be targeted to ensure interventions are most ...
L. Barnett +12 more
semanticscholar +1 more source
, 2020 This paper aims to develop a systematic review on graduate employability and competence development, intending to present an international perspective on the matter.
M. Abelha +4 more
semanticscholar +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Pixel-Wise Defect Detection by CNNs without Manually Labeled Training Data
Applied Artificial Intelligence, 2019 In machine learning driven surface inspection one often faces the issue that defects to be detected are difficult to make available for training, especially when pixel-wise labeling is required.
M. Haselmann, D. P. Gruber
doaj +1 more source
Poroelasticity Contributes to Hydraulic‐Stimulation Induced Pressure Changes
Geophysical Research Letters, 2021 High‐pressure fluid injections cause transient pore pressure changes over large distances, which may induce seismicity. The zone of influence for such an injection was studied at high spatial resolutions in six decameter‐scaled fluid injection ...
N. O. Dutler +8 more
doaj +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Temporomandibular disorders in an adult population in northern Norway: A cross‐sectional study
Clinical and Experimental Dental Research, 2021 Objectives The aim of the study was to assess the prevalence of symptoms indicative of temporomandibular disorders (TMD) in an adult population in Troms County in Northern Norway, as well as the associations between TMD and socio‐demographic factors ...
Elin Hadler‐Olsen +5 more
doaj +1 more source
Archives of General Psychiatry, 2002 BACKGROUND Manifestations of core social deficits in autism are more pronounced in everyday settings than in explicit experimental tasks. To bring experimental measures in line with clinical observation, we report a novel method of quantifying atypical ...
A. Klin +4 more
semanticscholar +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source