Results 41 to 50 of about 83,909 (262)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Contemplation on Competency-based Curriculum in Medical Education [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2016
Introduction: One of the approaches to explaining the relationship between education and the world of work, and reducing the gap between students’ knowledge and their professional needs is competency-based curriculum.
Akbar Hedayati, Hasan Maleki, Ali reza Sadeghi, Esmaeil Saadipour   +3 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

L’internationalisation de l’approche par compétences, le cas du Mexique, entre transfert de modèle et résistance

Cahiers de la Recherche sur l'Education et les Savoirs, 2017
At the global level the competency based approach (CBA) is today the pedagogical approach which underlies most educational reforms. Originating in the professional and vocational world, this approach found defenders in the academic world as well as among
Nathalie Portilla
doaj   +1 more source

Competence-based approach in the training of physicists

Journal of Physics: Conference Series, 2021
Abstract Competence is the ability of an individual to solve various practical tasks, a set of knowledge, skills and abilities required to perform a specific practical activity. The use of intersubject connections during the training of physicists, in our opinion, will make it possible to prepare specialists with a broad Outlook and good
Vasylyshyn, Vitalii, Yekimov, Sergey, Nakhod, Svitlana, Voytsekhovska, Yuliya, Otroshchenko, Nataliia, Gavrilko, Tetiana, Zheludenko, Maryna, Mikheev, Andriy, Vynnyk, Tetiana   +8 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Professionally Oriented Practice in Graduate Students in the Context of Networking between University and School

Психологическая наука и образование (2007. Online), 2016
The paper describes the experience of organising professionally oriented practice for graduate students in the context of networking. The model of in-depth professionally oriented practice for students of the master’s programme in Psychology and ...
Gutina G.Y., , Yemelyanova I.V.,
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Building a Team of Teachers for Designing and Implementation of Modul Educational Programs

Психологическая наука и образование (2007. Online), 2015
This article can be classified as thematic review, since it shows the actual experience of a human resources choice for the design and implementation of modular educational programs.
Kashtanova S.N. , Kudryavtsev V.A.
doaj   +1 more source