Results 41 to 50 of about 28,894,011 (286)
Acquisition of value-based competencies for effective management of training of specialists
Менеджмент та підприємництво: тренди розвитку, 2022 The purpose of this study is to examine the features of the acquisition of value-based competencies for effective management of training of specialists. Higher education institutions are tasked with implementing educational programs that allow to achieve
Maryna Ivanova +3 more
doaj +1 more source
[Tolerating uncertainty: Towards a competence-based approach].
La Revue de medecine interne, 2023 L’incertitude est inhérente à tous les aspects de la pratique médicale. Le concept d’incertitude dans le soin reste largement à explorer, et l’étude des déterminants et fondements mêmes de cette incertitude pourrait bénéficier de l’éclairage de disciplines telles que l’épistémologie, la sociologie, les mathématiques, ou encore la philosophie.
Belhomme, Nicolas +5 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Lack of consensus among competency ratings of the same occupation: Noise or substance? [PDF]
, 2010 Although rating differences among incumbents of the same occupation have traditionally been viewed as error variance in the work analysis domain, such differences might often capture substantive discrepancies in how incumbents approach their work.
Juan I. Sanchez +8 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Contemplation on Competency-based Curriculum in Medical Education [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2016 Introduction: One of the approaches to explaining the relationship between education and the world of work, and reducing the gap between students’ knowledge and their professional needs is competency-based curriculum.
Akbar Hedayati +3 more
doaj
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Transforming a competency model to parameterised questions in assessment [PDF]
, 2009 The problem of comparing and matching different learners’ knowledge arises when assessment systems use a one-dimensional numerical value to represent “knowledge level”.
Lester Gilbert +5 more
core +1 more source