Results 51 to 60 of about 365,100 (332)

Rocaglates induce gain-of-function alterations to eIF4A and eIF4F [PDF]

, 2020
Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies.
Baranov, Pavel V., Brown, Lauren E., Cencic, Regina, Chu, Jennifer, Devine, William G., Henkel, Thomas, Merrick, William C., O'Connor, Patrick B. F., Pelletier, Jerry, Porco, Jr., John A., Robert, Francis, Selznick, Asher, Zhang, Wenhan   +12 more
core   +1 more source

Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer

International Journal of Molecular Sciences, 2019
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth and metastasis.
Liye Wang, Kwang Bog Cho, Yan Li, Gabriel Tao, Zuoxu Xie, Bin Guo   +5 more
semanticscholar   +1 more source

Competing endogenous RNA crosstalk at system level.

PLoS Computational Biology, 2019
microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules. Competition to bind miRNAs tends in turn to correlate their targets, establishing effective RNA-RNA interactions that can influence expression ...
Mattia Miotto, Enzo Marinari, Andrea De Martino   +2 more
doaj   +1 more source

LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network

Cancer Cell International, 2019
Background It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed to develop a competing endogenous
Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge, Bin Wu   +5 more
doaj   +1 more source

Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer

Clinical Cancer Research, 2018
Purpose: Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the overall biological roles and clinical significance of most lncRNAs in gastric carcinogenesis are not fully ...
Xin Chen, Zhenyao Chen, Shanxun Yu, Feng-qi Nie, Shuai Yan, Pei Ma, Qin-nan Chen, Chen-chen Wei, Hangjiang Fu, Tianwei Xu, Sheng-nan Ren, Ming Sun, Zhaoxia Wang   +12 more
semanticscholar   +1 more source

Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cells

Cellular and Molecular Life Sciences, 2022
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of COVID-19.
D. Barbagallo, C. I. Palermo, C. Barbagallo, R. Battaglia, A. Caponnetto, Vittoria Spina, M. Ragusa, C. Di Pietro, G. Scalia, M. Purrello   +9 more
semanticscholar   +1 more source

Fluorescent protein tagging confirms the presence of ribosomal proteins atDrosophilapolytene chromosomes [PDF]

, 2013
\ud \ud Most ribosomal proteins (RPs) are stoichiometrically incorporated into ribosomal subunits and play essential roles in ribosome biogenesis and function.
Bischof, Bohnsack, Brogna, Coleno-Costes, Dai, Dai, De, De, Freeman, Gavin, Gerlitz, Hurt, Inada, Johansen, Jurica, Klinge, Kondrashov, Lam, Lee, Malygin, Marygold, Ni, Ramanathan, Shi, Shopland, Steitz, Warner, Zhimulev   +27 more
core   +3 more sources

Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure

Reproductive Biology and Endocrinology, 2021
Background The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons.
Jialyu Huang, N. Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qian-Qian Chen, Jing Zhu, Qiongfang Wu   +7 more
semanticscholar   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells [PDF]

, 2016
The RhoA and RhoC GTPases act via the ROCK1 and ROCK2 kinases to promote actomyosin contraction, resulting in directly induced changes in cytoskeleton structures and altered gene transcription via several possible indirect routes.
Clark, William, Kalna, Gabriela, Olson, Michael F., Rath, Nicola   +3 more
core   +1 more source