Results 71 to 80 of about 238,324 (282)

Integrated Bioinformatic Analysis of Competing Endogenous RNA Network of Choriocarcinoma

Medical Science Monitor, 2021
BACKGROUND Numerous studies have demonstrated that noncoding RNAs are involved in choriocarcinoma (CC). The competing endogenous RNA (ceRNA) network plays an important role in the occurrence and development of carcinoma. However, the involvement of the ceRNA network in CC remains unclear.
Tan, Qianxia, Tan, Zhihui, Liu, Junliang, Mo, Yanqun, Liu, Huining   +4 more
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A quantitative understanding of microRNA‐ mediated competing endogenous RNA regulation [PDF]

Quantitative Biology, 2016
MicroRNA (miRNA) plays key roles in post‐transcriptional regulations. Recently, a competing endogenous RNA (ceRNA) hypothesis has been proposed that miRNA targets could communicate and regulate each other through titrating shared miRNAs, which provides a new layer of gene regulation.
Ye Yuan, Xinying Ren, Zhen Xie, Xiaowo Wang   +3 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cancer Stem Cells and Competing Endogenous RNAs

, 2022
Cancer stem cells (CSCs) are one of the cell types that account for cancer heterogeneity. They arrest in the G0 phase and generate non-CSC progeny by self-renewing and pluripotency activity, resulting in tumor recurrence, metastasis, and chemoresistance. One CSC can stimulate tumor relapse and can re-grow a metastatic tumor.
Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori   +9 more
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A competing endogenous RNA network reveals key lncRNAs associated with sepsis

Molecular Genetics & Genomic Medicine, 2021
Background This study set out to determine key lncRNAs correlated with sepsis via constructing competing endogenous RNA (ceRNA) network. Methods Three septic patients and three healthy controls were recruited to obtain lncRNA profiles in this current ...
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao   +6 more
doaj   +1 more source

MicroRNA and circular RNA profiling in the deposited fat tissue of Sunite sheep

Frontiers in Veterinary Science, 2022
As the most typical deposited fat, tail fat is an important energy reservoir for sheep adapted to harsh environments and plays an important role as a raw material in daily life.
Xige He, Rihan Wu, Yueying Yun, Yueying Yun, Xia Qin, Yajuan Huang, Lu Chen, Yunfei Han, Jindi Wu, Lina Sha, Gerelt Borjigin   +10 more
doaj   +1 more source

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs [PDF]

, 2011
SummaryHere, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for common microRNAs, with microRNA response elements as the foundation of this interaction.
Provero, Paolo, Poliseno, Laura, Yvonne Tay, Lev Kats, Isidore Rigoutsos, Pier Paolo Pandolfi, Leonardo Salmena, Tay, Yvonne, Judy Lieberman, Tan, Shen Mynn, Ala, Ugo, Lieberman, Judy, Paolo Provero, Kats, Lev, Pandolfi De Rinaldis, Pier Paolo, Laura Poliseno, Di Cunto, Ferdinando, Florian Karreth, Weiss, Dror, Ugo Ala, Dror Weiss, Karreth, Florian, Salmena, Leonardo, Pandolfi, Pier Paolo, Shen Mynn Tan, Ferdinando Di Cunto, Rigoutsos, Isidore   +26 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source