Results 71 to 80 of about 299,250 (314)

Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer’s Disease: A Systematic Scoping Review

Frontiers in Aging Neuroscience, 2021
Alzheimer’s disease (AD) is a heterogeneous degenerative brain disorder with a rising prevalence worldwide. The two hallmarks that characterize the AD pathophysiology are amyloid plaques, generated via aggregated amyloid β, and neurofibrillary tangle ...
Hani Sabaie, Nazanin Amirinejad, M. Asadi, Abbas Jalaiei, Yousef Daneshmandpour, Omidvar Rezaei, M. Taheri, M. Rezazadeh   +7 more
semanticscholar   +1 more source

Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors

Cancer Cell International, 2020
Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer.
Hui-shan Wang, Wen Zhang, Han-long Zhu, Quan-peng Li, Lin Miao   +4 more
doaj   +1 more source

Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder

Frontiers in Cell and Developmental Biology, 2021
Lubrication disorder is a common health issue that manifests as insufficient sexual arousal at the beginning of sex. It often causes physical and psychological distress.
Shengnan Cong, Jinlong Li, Jingjing Zhang, Jingyi Feng, Aixia Zhang, Aixia Zhang, Lianjun Pan, Jiehua Ma   +7 more
doaj   +1 more source

Progress in Competing Endogenous RNA and Cancer

Journal of Cancer Therapy, 2015
The competing endogenous RNA (ceRNA) hypothesis was introduced as a previously unrecognized gene regulatory layer. This is a recently discovered hypothesis about how mRNAs, pseudogene transcripts, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) regulate post-transcriptional expression by sharing common microRNA response elements (MREs ...
Ting Zhang, Weiguo Huang
openaire   +2 more sources

Long noncoding RNA associated-competing endogenous RNAs in gastric cancer [PDF]

Scientific Reports, 2014
Some long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of lncRNA associated-ceRNAs in oncogenesis are not fully understood. Here, based on lncRNA microarray data of gastric cancer, bioinformatic algorithm miRcode and microRNA (miRNA) targets ...
Xia, Tian, Liao, Qi, Jiang, Xiaoming, Shao, Yongfu, Xiao, Bingxiu, Xi, Yang, Guo, Junming   +6 more
openaire   +2 more sources

AFCMEasyModel: An Easy Interface for Modeling Competing Endogenous RNA Networks using ODEs [PDF]

, 2017
Competing endogenous RNA networks have been considered to be important regulators of genetic data expression. Circular RNAs and microRNAs interact to form a circular sponge that have been shown to regulate messenger RNAs and hence regulating gene ...
Mohammad M. Tarek
core   +1 more source

LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma [PDF]

, 2022
Genomic and epigenomic studies revealed dysregulation of long non-coding RNAs in many cancer entities, including liver cancer. We identified an epigenetic mechanism leading to upregulation of the long intergenic non-coding RNA 152 (LINC00152) expression ...
Longerich, Thomas, Kai Breuhahn, Breuhahn, Kai, Gaisa, Nadine T., Nadine T. Gaisa, Tom Luedde, Pellegrino, Rossella, Constantin Schwab, Gaisa, Nadine T, Ulf P. Neumann, Rossella Pellegrino, Costa, Ivan G, Neumann, Ulf P, Mirco Castoldi, Skawran, Britta, Ticconi, Fabio, Schwab, Constantin, Castoldi, Mirco, Sven H. Loosen, Fabian Rose, Loosen, Sven H., Jan Budczies, Budczies, Jan, Loosen, Sven H, Rose, Fabian, Neumann, Ulf P., Britta Skawran, Ivan G. Costa, Costa, Ivan G., Fabio Ticconi, Luedde, Tom, Thomas Longerich   +31 more
core   +1 more source

Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information [PDF]

, 2019
© 2019 The Author(s). Background: A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called a ceRNA crosstalk.
Hutvagner, G, Li, J, Lan, C, Peng, H
core   +1 more source

Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure

Reproductive Biology and Endocrinology, 2021
Background The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons.
Jialyu Huang, N. Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qian-Qian Chen, Jing Zhu, Qiongfang Wu   +7 more
semanticscholar   +1 more source

Table_1_Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer.docx [PDF]

, 2021
Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the ...
Guangbing Xiong (3555230), Jikuan Jin (11601934), Feng Zhu (685), Xu Li (23864), Ruizhi He (5890487), Xiaoxiang Wang (379686), Renyi Qin (2831852), Shutao Pan (7143704), Min Wang (21070), Jianwei Zheng (1626523), Feng Peng (400899)   +10 more
core   +1 more source